{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:36:50Z","timestamp":1791009410206,"version":"4.1.0"},"reference-count":46,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":6598,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,10]]},"abstract":"<jats:p>Scottish Blackface ewes from cobalt-deficient farmland were fed a diet containing 0.06 mg cobalt per kg dry matter from approximately 30 days before embryo recovery\/transfer until lambing. Ewes remained untreated (\u2013Co; n = 82) or were given an intraruminal cobalt-containing bolus to compensate for the dietary deficit (+Co; n = 82). Ewes used as embryo donors (\u2013Co, n = 17; +Co, n = 16) were artificially inseminated with semen from a single Suffolk sire. Day 6 embryos obtained from \u2013Co and +Co donors were transferred in singleton to \u2013Co and +Co recipients in a 2 \u00d7 2 factorial-designed experiment to determine the effects of cobalt\/vitamin B12 status during the periconception period (factor 1) and pregnancy (factor 2) on lamb viability at birth. Mean (\u00b1 s.e.m.) circulating concentrations of vitamin B12 in \u2013Co and +Co donors at ovum recovery were 182 \u00b1 10 and 1288 \u00b1 64 pmol L\u20131, respectively (P &amp;lt; 0.001), and the number of corpora lutea per ewe ovulating was 9.9 \u00b1 1.6 and 14.4 \u00b1 1.3, respectively (P &amp;lt; 0.05). Treatment did not affect the proportion of recovered ova that contained &amp;gt;32 cells (viable) or the median stage of development (late morula), but viable ova recovered from \u2013Co v. +Co ewes had a better morphological grade (2.0 \u00b1 0.1 v. 2.20 \u00b1 0.04, respectively; P &amp;lt; 0.01). There was no effect of treatment on the proportion of recipient ewes that became pregnant. Circulating concentrations of vitamin B12 were lower in \u2013Co than +Co ewes during pregnancy (P &amp;lt; 0.001) and at birth in lambs born to \u2013Co ewes compared with those born to +Co ewes (P &amp;lt; 0.001). There was no effect of donor or recipient cobalt\/vitamin B12 status on lamb birthweight, neonatal vigour or neonatal rectal temperatures, but lambs derived from +Co v. \u2013Co embryo donors were more active in the first 3 days after birth (P &amp;lt; 0.05). Results show that sub-clinical cobalt\/vitamin B12 deficiency reduces ovulatory response in superovulated ewes and that periconception nutrition can affect neonatal lamb behaviour.<\/jats:p>","DOI":"10.1071\/rd07012","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T17:52:04Z","timestamp":1178819524000},"page":"553-562","source":"Crossref","is-referenced-by-count":25,"title":["Effects of cobalt\/vitamin B12 status in ewes on ovum development and lamb viability at birth"],"prefix":"10.1071","volume":"19","author":[{"given":"Linda M.","family":"Mitchell","sequence":"first","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Robinson","sequence":"additional","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."},{"name":"DCorresponding author. Email: john.robinson@sac.ac.uk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Watt","sequence":"additional","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"McEvoy","sequence":"additional","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."},{"name":"CPresent address: Sustainable Livestock Systems Group, SAC, Roslin Biocentre, Roslin, Midlothian EH25 9PS, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl J.","family":"Ashworth","sequence":"additional","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."},{"name":"CPresent address: Sustainable Livestock Systems Group, SAC, Roslin Biocentre, Roslin, Midlothian EH25 9PS, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Rooke","sequence":"additional","affiliation":[{"name":"ASustainable Livestock Systems Group, SAC, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, Scotland."},{"name":"CPresent address: Sustainable Livestock Systems Group, SAC, Roslin Biocentre, Roslin, Midlothian EH25 9PS, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy M.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"BSustainable Livestock Systems Group, SAC, Bush Estate, Penicuik, Midlothian EH26 0PH, Scotland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"2025102818361665500_R1"},{"key":"2025102818361665500_R2"},{"key":"2025102818361665500_R3"},{"key":"2025102818361665500_R4"},{"key":"2025102818361665500_R5"},{"key":"2025102818361665500_R6"},{"key":"2025102818361665500_R7"},{"key":"2025102818361665500_R8"},{"key":"2025102818361665500_R9"},{"key":"2025102818361665500_R10"},{"key":"2025102818361665500_R11"},{"key":"2025102818361665500_R12"},{"key":"2025102818361665500_R13"},{"key":"2025102818361665500_R14"},{"key":"2025102818361665500_R15"},{"key":"2025102818361665500_R16"},{"key":"2025102818361665500_R17"},{"key":"2025102818361665500_R18"},{"key":"2025102818361665500_R19"},{"key":"2025102818361665500_R20"},{"key":"2025102818361665500_R21"},{"key":"2025102818361665500_R22"},{"key":"2025102818361665500_R23"},{"key":"2025102818361665500_R24"},{"key":"2025102818361665500_R25"},{"key":"2025102818361665500_R26"},{"key":"2025102818361665500_R27"},{"key":"2025102818361665500_R28"},{"key":"2025102818361665500_R29"},{"key":"2025102818361665500_R30"},{"key":"2025102818361665500_R31"},{"key":"2025102818361665500_R32"},{"key":"2025102818361665500_R33"},{"key":"2025102818361665500_R34"},{"key":"2025102818361665500_R35"},{"key":"2025102818361665500_R36"},{"key":"2025102818361665500_R37"},{"key":"2025102818361665500_R38"},{"key":"2025102818361665500_R39"},{"key":"2025102818361665500_R40"},{"key":"2025102818361665500_R41"},{"key":"2025102818361665500_R42"},{"key":"2025102818361665500_R43"},{"key":"2025102818361665500_R44"},{"key":"2025102818361665500_R45"},{"key":"2025102818361665500_R46"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/19\/4\/553\/301216\/rd07012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/19\/4\/553\/301216\/rd07012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:36:22Z","timestamp":1761690982000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/19\/4\/553\/48498\/Effects-of-cobalt-vitamin-B12-status-in-ewes-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5,10]]}},"URL":"https:\/\/doi.org\/10.1071\/rd07012","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,4]]}}}