{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:45:18Z","timestamp":1771469118954,"version":"3.50.1"},"reference-count":54,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":5558,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,31]]},"abstract":"<jats:p>The present study was conducted to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cyclophosphamide (CP)-induced testicular and spermatozoal toxicity associated with the oxidative stress and apoptosis in male rats. Forty-eight healthy adult male Sprague-Dawley rats were divided into six groups of eight rats each. The control group was treated with placebo; the LC, EA and CP groups were given LC (10 mg kg\u20131), EA (2 mg kg\u20131) and CP (15 mg kg\u20131), respectively, alone; the CP+LC group was treated with a combination of CP (15 mg kg\u20131) and LC (10 mg kg\u20131); and the CP+EA group was treated with a combination of CP (15 mg kg\u20131) and EA (2 mg kg\u20131). All treatments were maintained for 8 weeks. At the end of the treatment period, bodyweight and the weight of the reproductive organs, sperm concentration and motility, testicular tissue lipid peroxidation, anti-oxidant enzyme activity and apoptosis (i.e. Bax and Bcl-2 proteins) were determined. Administration of CP resulted in significant decreases in epididymal sperm concentration and motility and significant increases in malondialdehyde levels. Although CP significantly increased the number of Bax-positive (apoptotic) cells, it had no effect on the number of Bcl-2-positive (anti-apoptotic) cells compared with the control group. However, combined treatment of rats with LC or EA in addition to CP prevented the development of CP-induced lipid peroxidation and sperm and testicular damage. In conclusion, CP-induced lipid peroxidation leads to structural and functional damage, as well as apoptosis, in spermatogenic cells of rats. Both LC and EA protect against the development of these detrimental effects.<\/jats:p>","DOI":"10.1071\/rd09078","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T19:55:38Z","timestamp":1269978938000},"page":"587-596","source":"Crossref","is-referenced-by-count":73,"title":["Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis"],"prefix":"10.1071","volume":"22","author":[{"given":"Gaffari","family":"T\u00fcrk","sequence":"first","affiliation":[{"name":"ADepartment of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey."},{"name":"ECorresponding author. Email: gturk@firat.edu.tr"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Osman","family":"\u00c7eribasi","sequence":"additional","affiliation":[{"name":"BDepartment of Pathology, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Sakin","sequence":"additional","affiliation":[{"name":"CDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Mustafa Kemal University, 31040, Hatay, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"ADepartment of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Atessahin","sequence":"additional","affiliation":[{"name":"DDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2010,3,9]]},"reference":[{"key":"2025102818563022300_R1"},{"key":"2025102818563022300_R2"},{"key":"2025102818563022300_R3"},{"key":"2025102818563022300_R4"},{"key":"2025102818563022300_R5"},{"key":"2025102818563022300_R6"},{"key":"2025102818563022300_R7"},{"key":"2025102818563022300_R8"},{"key":"2025102818563022300_R9"},{"key":"2025102818563022300_R10"},{"key":"2025102818563022300_R11"},{"key":"2025102818563022300_R12"},{"key":"2025102818563022300_R13"},{"key":"2025102818563022300_R14"},{"key":"2025102818563022300_R15"},{"key":"2025102818563022300_R16"},{"key":"2025102818563022300_R17"},{"key":"2025102818563022300_R18"},{"key":"2025102818563022300_R19"},{"key":"2025102818563022300_R20"},{"key":"2025102818563022300_R21"},{"key":"2025102818563022300_R22"},{"key":"2025102818563022300_R23"},{"key":"2025102818563022300_R24"},{"key":"2025102818563022300_R25"},{"key":"2025102818563022300_R26"},{"key":"2025102818563022300_R27"},{"key":"2025102818563022300_R28"},{"key":"2025102818563022300_R29"},{"key":"2025102818563022300_R30"},{"key":"2025102818563022300_R31"},{"key":"2025102818563022300_R32"},{"key":"2025102818563022300_R33"},{"key":"2025102818563022300_R34"},{"key":"2025102818563022300_R35"},{"key":"2025102818563022300_R36"},{"key":"2025102818563022300_R37"},{"key":"2025102818563022300_R38"},{"key":"2025102818563022300_R39"},{"key":"2025102818563022300_R40"},{"key":"2025102818563022300_R41"},{"key":"2025102818563022300_R42"},{"key":"2025102818563022300_R43"},{"key":"2025102818563022300_R44"},{"key":"2025102818563022300_R45"},{"key":"2025102818563022300_R46"},{"key":"2025102818563022300_R47"},{"key":"2025102818563022300_R48"},{"key":"2025102818563022300_R49"},{"key":"2025102818563022300_R50"},{"key":"2025102818563022300_R51"},{"key":"2025102818563022300_R52"},{"key":"2025102818563022300_R53"},{"key":"2025102818563022300_R54"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/4\/587\/303711\/rd09078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/4\/587\/303711\/rd09078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:56:37Z","timestamp":1761692197000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/22\/4\/587\/48934\/Antiperoxidative-and-anti-apoptotic-effects-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,9]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3,31]]}},"URL":"https:\/\/doi.org\/10.1071\/rd09078","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,9]]}}}