{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:55:00Z","timestamp":1775562900263,"version":"3.50.1"},"reference-count":66,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":5529,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,29]]},"abstract":"<jats:p>Endometrial cells take part in embryo\u2013maternal communication, as well as supporting the immune system in defending against invading pathogens. The aim of the present study was to examine the mRNA expression of factors that have been suggested to be involved in both events in the bovine endometrial epithelium, namely bovine granulocyte chemotactic protein 2 (CXCL5), interleukin-1 beta (IL1B), IL6, IL8, tumour necrosis factor (TNF), cyclooxygenase 2 (PTGS2) and haptoglobin (HP). Samples were collected in vivo from cows on Days 21\u201327 postpartum by the cytobrush method to evaluate the correlation between inflammatory factors and uterine health (cows with signs of clinical or subclinical endometritis and healthy cows). Bovine uteri were collected at the abattoir to investigate oestrous cycle-dependent mRNA expression patterns. Real-time reverse transcription\u2013polymerase chain reaction revealed that the expression of CXCL5, IL1B, IL8 and TNF mRNA was significantly higher in cows with subclinical or clinical endometritis compared with healthy cows. The expression of CXCL5, IL1B and IL8 mRNA was increased around ovulation compared with the luteal phase. There was no indication of either oestrous cycle-dependent expression or a correlation with uterine health for IL6, PTGS2 and HP transcripts. These results suggest that CXCL5, IL1B, IL8 and TNF may represent potential marker genes for the detection of cows with subclinical endometritis and for monitoring new therapeutic approaches.<\/jats:p>","DOI":"10.1071\/rd09120","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T21:25:20Z","timestamp":1272489920000},"page":"818-829","source":"Crossref","is-referenced-by-count":128,"title":["Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis"],"prefix":"10.1071","volume":"22","author":[{"given":"Claudia","family":"Fischer","sequence":"first","affiliation":[{"name":"AInstitute of Veterinary Biochemistry, Freie Universit\u00e4t Berlin, Oertzenweg 19b, 14163 Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Drillich","sequence":"additional","affiliation":[{"name":"BClinic for Animal Reproduction, Freie Universit\u00e4t Berlin, K\u00f6nigsweg 63, 14163 Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Odau","sequence":"additional","affiliation":[{"name":"AInstitute of Veterinary Biochemistry, Freie Universit\u00e4t Berlin, Oertzenweg 19b, 14163 Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Heuwieser","sequence":"additional","affiliation":[{"name":"BClinic for Animal Reproduction, Freie Universit\u00e4t Berlin, K\u00f6nigsweg 63, 14163 Berlin, Germany."},{"name":"CPresent address: Animal Welfare Program, Faculty of Land and Food Systems, The University of British Columbia, 2357 Main Mall, Vancouver V6T 1Z4, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Einspanier","sequence":"additional","affiliation":[{"name":"AInstitute of Veterinary Biochemistry, Freie Universit\u00e4t Berlin, Oertzenweg 19b, 14163 Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Gabler","sequence":"additional","affiliation":[{"name":"AInstitute of Veterinary Biochemistry, Freie Universit\u00e4t Berlin, Oertzenweg 19b, 14163 Berlin, Germany."},{"name":"DCorresponding author. Email: gablerch@zedat.fu-berlin.de"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2010,4,7]]},"reference":[{"key":"2025102818571463400_R1"},{"key":"2025102818571463400_R2"},{"key":"2025102818571463400_R3"},{"key":"2025102818571463400_R4"},{"key":"2025102818571463400_R5"},{"key":"2025102818571463400_R6"},{"key":"2025102818571463400_R7"},{"key":"2025102818571463400_R8"},{"key":"2025102818571463400_R9"},{"key":"2025102818571463400_R10"},{"key":"2025102818571463400_R11"},{"key":"2025102818571463400_R12"},{"key":"2025102818571463400_R13"},{"key":"2025102818571463400_R14"},{"key":"2025102818571463400_R15"},{"key":"2025102818571463400_R16"},{"key":"2025102818571463400_R17"},{"key":"2025102818571463400_R18"},{"key":"2025102818571463400_R19"},{"key":"2025102818571463400_R20"},{"key":"2025102818571463400_R21"},{"key":"2025102818571463400_R22"},{"key":"2025102818571463400_R23"},{"key":"2025102818571463400_R24"},{"key":"2025102818571463400_R25"},{"key":"2025102818571463400_R26"},{"key":"2025102818571463400_R27"},{"key":"2025102818571463400_R28"},{"key":"2025102818571463400_R29"},{"key":"2025102818571463400_R30"},{"key":"2025102818571463400_R31"},{"key":"2025102818571463400_R32"},{"key":"2025102818571463400_R33"},{"key":"2025102818571463400_R34"},{"key":"2025102818571463400_R35"},{"key":"2025102818571463400_R36"},{"key":"2025102818571463400_R37"},{"key":"2025102818571463400_R38"},{"key":"2025102818571463400_R39"},{"key":"2025102818571463400_R40"},{"key":"2025102818571463400_R41"},{"key":"2025102818571463400_R42"},{"key":"2025102818571463400_R43"},{"key":"2025102818571463400_R44"},{"key":"2025102818571463400_R45"},{"key":"2025102818571463400_R46"},{"key":"2025102818571463400_R47"},{"key":"2025102818571463400_R48"},{"key":"2025102818571463400_R49"},{"key":"2025102818571463400_R50"},{"key":"2025102818571463400_R51"},{"key":"2025102818571463400_R52"},{"key":"2025102818571463400_R53"},{"key":"2025102818571463400_R54"},{"key":"2025102818571463400_R55"},{"key":"2025102818571463400_R56"},{"key":"2025102818571463400_R57"},{"key":"2025102818571463400_R58"},{"key":"2025102818571463400_R59"},{"key":"2025102818571463400_R60"},{"key":"2025102818571463400_R61"},{"key":"2025102818571463400_R62"},{"key":"2025102818571463400_R63"},{"key":"2025102818571463400_R64"},{"key":"2025102818571463400_R65"},{"key":"2025102818571463400_R66"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/5\/818\/303867\/rd09120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/5\/818\/303867\/rd09120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:57:18Z","timestamp":1761692238000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/22\/5\/818\/48950\/Selected-pro-inflammatory-factor-transcripts-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,7]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,4,29]]}},"URL":"https:\/\/doi.org\/10.1071\/rd09120","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,7]]}}}