{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:09:42Z","timestamp":1767830982184,"version":"3.49.0"},"reference-count":35,"publisher":"CSIRO Publishing","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":5542,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,31]]},"abstract":"<jats:p>Integrins are transmembrane extracellular matrix (ECM) receptors composed of a- and \u00df-subunits. Integrins can cluster to form focal adhesions and, because there is significant ECM remodelling and focal adhesion turnover in the rat myometrium during late pregnancy, we hypothesised that the expression of a1, a3 and \u00df1 integrin subunits in the rat myometrium would be altered at this time to accommodate these processes. Expression of a1 and \u00df1 integrin subunit mRNA was significantly increased on Days 6\u201323 of pregnancy compared with non-pregnant (NP) and postpartum (PP) time points (P &amp;lt; 0.05). In contrast, a3 integrin subunit mRNA expression was significantly increased on Days 14, 21 and 22 compared with NP, Day 10, 1 day PP and 4 days PP (P &amp;lt; 0.05). A relative gene expression study revealed that, of the integrins studied, the expression of \u00df1 integrin mRNA was highest in pregnant rat myometrium. The a1, a3 and \u00df1 integrin subunit proteins became immunolocalised to myocyte membranes in situ by late pregnancy and labour in both myometrial muscle layers. Increased a1, a3 and \u00df1 integrin gene expression during gestation and the specific detection of these subunits in myocyte membranes during late pregnancy and labour may contribute to the cell\u2013ECM interactions required for the development of a mechanical syncytium.<\/jats:p>","DOI":"10.1071\/rd09163","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T19:55:38Z","timestamp":1269978938000},"page":"718-732","source":"Crossref","is-referenced-by-count":13,"title":["Spatiotemporal expression of a1, a3 and \u00df1 integrin subunits is altered in rat myometrium during pregnancy and labour"],"prefix":"10.1071","volume":"22","author":[{"given":"S. J.","family":"Williams","sequence":"first","affiliation":[{"name":"ADivision of BioMedical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John\u2019s, NL A1B 3V6, Canada."},{"name":"CThese authors contributed equally to this work."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Shynlova","sequence":"additional","affiliation":[{"name":"BSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada."},{"name":"CThese authors contributed equally to this work."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Lye","sequence":"additional","affiliation":[{"name":"BSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"MacPhee","sequence":"additional","affiliation":[{"name":"ADivision of BioMedical Sciences, Faculty of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John\u2019s, NL A1B 3V6, Canada."},{"name":"DCorresponding author. Email: dmacphee@mun.ca"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2010,3,25]]},"reference":[{"key":"2025102818575899200_R1"},{"key":"2025102818575899200_R2"},{"key":"2025102818575899200_R3"},{"key":"2025102818575899200_R4"},{"key":"2025102818575899200_R5"},{"key":"2025102818575899200_R6"},{"key":"2025102818575899200_R7"},{"key":"2025102818575899200_R8"},{"key":"2025102818575899200_R9"},{"key":"2025102818575899200_R10"},{"key":"2025102818575899200_R11"},{"key":"2025102818575899200_R12"},{"key":"2025102818575899200_R13"},{"key":"2025102818575899200_R14"},{"key":"2025102818575899200_R15"},{"key":"2025102818575899200_R16"},{"key":"2025102818575899200_R17"},{"key":"2025102818575899200_R18"},{"key":"2025102818575899200_R19"},{"key":"2025102818575899200_R20"},{"key":"2025102818575899200_R21"},{"key":"2025102818575899200_R22"},{"key":"2025102818575899200_R23"},{"key":"2025102818575899200_R24"},{"key":"2025102818575899200_R25"},{"key":"2025102818575899200_R26"},{"key":"2025102818575899200_R27"},{"key":"2025102818575899200_R28"},{"key":"2025102818575899200_R29"},{"key":"2025102818575899200_R30"},{"key":"2025102818575899200_R31"},{"key":"2025102818575899200_R32"},{"key":"2025102818575899200_R33"},{"key":"2025102818575899200_R34"},{"key":"2025102818575899200_R35"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/4\/718\/304023\/rd09163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/22\/4\/718\/304023\/rd09163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:58:00Z","timestamp":1761692280000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/22\/4\/718\/48967\/Spatiotemporal-expression-of-a1-a3-and-1-integrin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,25]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3,31]]}},"URL":"https:\/\/doi.org\/10.1071\/rd09163","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,25]]}}}