{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:15:02Z","timestamp":1788200102271,"version":"build-2803163510"},"reference-count":62,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":5136,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,3]]},"abstract":"<jats:p>The composition and organisation of extracellular matrix (ECM)-related molecules change during development. These components interact with different cell surface receptors to modulate the transduction of signals for cell growth, differentiation, migration, proliferation and apoptosis. Previous findings in the teleost fish gilthead seabream (Sparus aurata L., Teleostei), a marine protandrous hermaphrodite fish, showed that endocrine and immune stimuli are able to modulate the expression of ECM-related molecules, as well as specific correlations between them. In the present study, quantitative reverse transcription\u2013polymerase chain reaction was used to examine the gene expression profile of \u00df1 integrin isoform b (ITGB1b) and its possible role in reproductive physiology, especially in relation to spermatogenesis. Expression profiles were analysed in the context of the reproductive cycle (RC) and in relation with other ECM-related molecules, including matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, tissue-specific inhibitor of metalloproteinase (TIMP)-2a, TIMP-2b, collagen (COL1A1) and ITGB1a. Expression of ITGB1b was found in the testis and brain and, to some extent, in endothelial cells. In contrast, ITGB1a was expressed ubiquitously. In the testis, the ITGB1b expression peaked during spermatogenesis, whereas the expression of the other ECM-related molecules is induced mainly during the post-spawning stage, both stages of marked tissue remodelling during the first and second RC in males. In addition, in fish exposed to the endocrine disruptor 17a-ethynyloestradiol (at 5 and 50 \u00b5g g\u20131 food during 7, 14 and 21 days), ITGB1b expression in the testis was inhibited in a dose- and time-dependent manner and was related to reduced serum levels of testosterone. Together, these results suggest a different functionality for the two ITGB1 isoforms in the gilthead seabream, where ITGB1b is more specifically involved in reproduction. This is the first report of an ITGB1 gene isoform whose expression is restricted to endocrine-related tissues in vertebrates.<\/jats:p>","DOI":"10.1071\/rd10351","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T09:44:26Z","timestamp":1307094266000},"page":"654-664","source":"Crossref","is-referenced-by-count":10,"title":["Identification of a \u00df1 integrin isoform with restricted tissue expression in a teleost fish"],"prefix":"10.1071","volume":"23","author":[{"given":"Patricia","family":"Castillo-Brice\u00f1o","sequence":"first","affiliation":[{"name":"ADepartment of Cell Biology and Histology, Faculty of Biology, Campus de Espinardo, University of Murcia, Murcia 30100, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cabas","sequence":"additional","affiliation":[{"name":"ADepartment of Cell Biology and Histology, Faculty of Biology, Campus de Espinardo, University of Murcia, Murcia 30100, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Arizcun","sequence":"additional","affiliation":[{"name":"BOceanographic Centre of Murcia, Spanish Oceanographic Institute (IEO), Puerto de Mazarr\u00f3n, 30860 Murcia, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Meseguer","sequence":"additional","affiliation":[{"name":"ADepartment of Cell Biology and Histology, Faculty of Biology, Campus de Espinardo, University of Murcia, Murcia 30100, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoriano","family":"Mulero","sequence":"additional","affiliation":[{"name":"ADepartment of Cell Biology and Histology, Faculty of Biology, Campus de Espinardo, University of Murcia, Murcia 30100, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonsa","family":"Garc\u00eda-Ayala","sequence":"additional","affiliation":[{"name":"ADepartment of Cell Biology and Histology, Faculty of Biology, Campus de Espinardo, University of Murcia, Murcia 30100, Spain."},{"name":"CCorresponding author. Email: agayala@um.es"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2011,5,5]]},"reference":[{"key":"2025102819225121300_R1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/J.CCA.2005.03.008","article-title":"Effects of 17alpha-ethynylestradiol on sexual development of male western mosquitofish, Gambusia affinis.","volume":"140","author":"Angus","year":"2005","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"2025102819225121300_R2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1203\/PDR.0B013E3181973AEE","article-title":"Ontogeny of MMPs and TIMPs in the murine neocortex.","volume":"65","author":"Bednarek","year":"2009","journal-title":"Pediatr. Res."},{"key":"2025102819225121300_R3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1046\/J.1525-1373.2000.22348.X","article-title":"The role of integrins in reproduction.","volume":"223","author":"Bowen","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"2025102819225121300_R4","doi-asserted-by":"publisher","first-page":"10 830","DOI":"10.1021\/BI901656F","article-title":"Updated biological roles for matrix metalloproteinases and new \u2018intracellular\u2019 substrates revealed by degradomics.","volume":"48","author":"Butler","year":"2009","journal-title":"Biochemistry"},{"key":"2025102819225121300_R5","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/J.MOLIMM.2008.12.005","article-title":"Collagen regulates the activation of professional phagocytes of the teleost fish gilthead seabream.","volume":"46","author":"Castillo-Brice\u00f1o","year":"2009","journal-title":"Mol. Immunol."},{"key":"2025102819225121300_R6","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/J.DCI.2010.05.007","article-title":"Correlated expression profile of extracellular matrix-related molecules during the inflammatory response of the teleost fish gilthead seabream.","volume":"34","author":"Castillo-Brice\u00f1o","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"2025102819225121300_R7","first-page":"103","article-title":"Simultaneous immunophenotypical assessment of troponin and extracellular matrix molecules in myocardium of patients with sudden cardiac death.","volume":"50","author":"Ceausu","year":"2009","journal-title":"Rom. J. Morphol. Embryol."},{"key":"2025102819225121300_R8","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1095\/BIOLREPROD.104.036103","article-title":"An overview of cell renewal in the testis throughout the reproductive cycle of a seasonal breeding teleost, the gilthead seabream (Sparus aurata L).","volume":"72","author":"Chaves-Pozo","year":"2005","journal-title":"Biol. Reprod."},{"key":"2025102819225121300_R9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1095\/BIOLREPROD.106.056036","article-title":"17Beta-estradiol triggers postspawning in spermatogenically active gilthead seabream (Sparus aurata L.) males.","volume":"76","author":"Chaves-Pozo","year":"2007","journal-title":"Biol. Reprod."},{"key":"2025102819225121300_R10","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1016\/J.MOLIMM.2008.01.031","article-title":"A role for matrix metalloproteinases in granulocyte infiltration and testicular remodelation in a seasonal breeding teleost.","volume":"45","author":"Chaves-Pozo","year":"2008","journal-title":"Mol. Immunol."},{"key":"2025102819225121300_R11","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1016\/J.MOLIMM.2008.01.018","article-title":"Pattern of expression of immune-relevant genes in the gonad of a teleost, the gilthead seabream (Sparus aurata L.).","volume":"45","author":"Chaves-Pozo","year":"2008","journal-title":"Mol. Immunol."},{"key":"2025102819225121300_R12","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/J.YGCEN.2008.03.004","article-title":"Sex steroids and metabolic parameter levels in a seasonal breeding fish (Sparus aurata L.).","volume":"156","author":"Chaves-Pozo","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025102819225121300_R13","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1262\/JRD.20203","article-title":"Early presence of immune cells in the developing gonad of the gilthead seabream (Sparus aurata Linnaeus 1758).","volume":"55","author":"Chaves-Pozo","year":"2009","journal-title":"J. Reprod. Dev."},{"key":"2025102819225121300_R14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/J.YDBIO.2005.06.035","article-title":"Ontogeny and regulation of matrix metalloproteinase activity in the zebrafish embryo by in vitro and in vivo zymography.","volume":"286","author":"Crawford","year":"2005","journal-title":"Dev. Biol."},{"key":"2025102819225121300_R15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/J.CEB.2006.12.013","article-title":"Integrins and the actin cytoskeleton.","volume":"19","author":"Delon","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025102819225121300_R16","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1186\/AR2153","article-title":"Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes.","volume":"9","author":"Djouad","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"2025102819225121300_R17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/J.YGCEN.2004.11.018","article-title":"Ontogeny of osteonectin expression in embryos and larvae of sea bream (Sparus auratus L.).","volume":"142","author":"Est\u00eav\u00e3o","year":"2005","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025102819225121300_R18","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0306-4522(02)00990-9","article-title":"Integrins regulate neuronal neurotrophin gene expression through effects on voltage-sensitive calcium channels.","volume":"118","author":"Gall","year":"2003","journal-title":"Neuroscience"},{"key":"2025102819225121300_R19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/SJ.JID.5700611","article-title":"Wound healing in the a2\u00df1 integrin-deficient mouse: altered keratinocyte biology and dysregulated matrix metalloproteinase expression.","volume":"127","author":"Grenache","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"2025102819225121300_R20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/J.MATBIO.2005.01.003","article-title":"Integrin evolution: insights from ascidian and teleost fish genomes.","volume":"24","author":"Huhtala","year":"2005","journal-title":"Matrix Biol."},{"key":"2025102819225121300_R21","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/J.1365-2613.2008.00637.X","article-title":"Back to basics: how the evolution of the extracellular matrix underpinned vertebrate evolution.","volume":"90","author":"Huxley-Jones","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"key":"2025102819225121300_R22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/DBIO.1996.0314","article-title":"Targeted mutations in cell adhesion genes: What have we learned from them?","volume":"180","author":"Hynes","year":"1996","journal-title":"Dev. Biol."},{"key":"2025102819225121300_R23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines.","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"2025102819225121300_R24","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1242\/DEV.00505","article-title":"Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development.","volume":"130","author":"Ivkovic","year":"2003","journal-title":"Development"},{"key":"2025102819225121300_R25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/J.BBAMEM.2008.12.013","article-title":"Integrins during evolution: evolutionary trees and model organisms.","volume":"1788","author":"Johnson","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2025102819225121300_R26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/J.BONE.2008.03.020","article-title":"Matrix metalloproteinases and bone.","volume":"43","author":"Krane","year":"2008","journal-title":"Bone"},{"key":"2025102819225121300_R27","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.4049\/jimmunol.145.8.2588","article-title":"Distinct adhesive properties of granulocytes and monocytes to endothelial cells under static and stirred conditions.","volume":"145","author":"Kuijpers","year":"1990","journal-title":"J. Immunol."},{"key":"2025102819225121300_R28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/J.EXPNEUROL.2009.10.007","article-title":"Pivotal role for beta-1 integrin in neuro-vascular remodelling after ischemic stroke.","volume":"221","author":"Lathia","year":"2010","journal-title":"Exp. Neurol."},{"key":"2025102819225121300_R29","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/J.MATBIO.2006.10.007","article-title":"Mammalian collagen receptors.","volume":"26","author":"Leitinger","year":"2007","journal-title":"Matrix Biol."},{"key":"2025102819225121300_R30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1477-7827-5-20","article-title":"Testicular involution prior to sex change in gilthead seabream is characterized by a decrease in DMRT1 gene expression and by massive leukocyte infiltration.","volume":"5","author":"Liarte","year":"2007","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2025102819225121300_R31","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1242\/dev.045377","article-title":"Endothelial beta1 integrins regulate sprouting and network formation during vascular development.","volume":"137","author":"Malan","year":"2010","journal-title":"Development"},{"key":"2025102819225121300_R32","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/J.CEB.2008.05.010","article-title":"Temporal and spatial regulation of integrins during development.","volume":"20","author":"Meighan","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025102819225121300_R33","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1038\/NI1407","article-title":"Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.","volume":"7","author":"M\u00f3csai","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025102819225121300_R34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/J.AQUATOX.2007.08.004","article-title":"Effects of 17alpha-ethynylestradiol on hormonal responses and xenobiotic biotransformation system of Atlantic salmon (Salmo salar).","volume":"85","author":"Mortensen","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"2025102819225121300_R35","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/J.CEB.2004.07.010","article-title":"Regulation of matrix biology by matrix metalloproteinases.","volume":"16","author":"Mott","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"2025102819225121300_R36","first-page":"7","article-title":"Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio).","volume":"20","author":"Mould","year":"2006","journal-title":"BMC Cell Biol."},{"key":"2025102819225121300_R37","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/J.DCI.2006.11.011","article-title":"Distribution of the professional phagocytic granulocytes of the bony fish gilthead seabream Sparus aurata L. during the ontogeny of lymphomyeloid organs and pathogen entry sites.","volume":"31","author":"Mulero","year":"2007","journal-title":"Dev. Comp. Immunol."},{"key":"2025102819225121300_R38","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1016\/J.MOLIMM.2008.01.017","article-title":"Vaccination of larvae of the bony fish gilthead seabream reveals a lack of correlation between lymphocyte development and adaptive immunocompetence.","volume":"45","author":"Mulero","year":"2008","journal-title":"Mol. Immunol."},{"key":"2025102819225121300_R39","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/NRM2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling.","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025102819225121300_R40","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/J.1749-6632.1999.TB07671.X","article-title":"Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity.","volume":"878","author":"Pilcher","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025102819225121300_R41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0169-328X(98)00007-2","article-title":"Localization and seizure-regulation of integrin beta 1 mRNA in adult rat brain.","volume":"55","author":"Pinkstaff","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"2025102819225121300_R42","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/J.MOLIMM.2005.07.028","article-title":"The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream.","volume":"43","author":"Roca","year":"2006","journal-title":"Mol. Immunol."},{"key":"2025102819225121300_R43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/J.BBAMCR.2005.08.003","article-title":"Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes.","volume":"1746","author":"Ronzi\u00e8re","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"2025102819225121300_R44","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/J.YDBIO.2009.10.026","article-title":"The extracellular matrix in development and morphogenesis: A dynamic view.","volume":"341","author":"Rozario","year":"2010","journal-title":"Dev. Biol."},{"key":"2025102819225121300_R45","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/09513590802090325","article-title":"Gelatinase A (MM-2), gelatinase B (MMP-9) and their inhibitors (TIMP 1, TIMP-2) in serum of women with endometriosis: significant correlation between MMP-2, MMP-9 and their inhibitors without difference in levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in relation to the severity of endometriosis.","volume":"24","author":"Salata","year":"2008","journal-title":"Gynecol. Endocrinol."},{"key":"2025102819225121300_R46","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/J.1524-475X.2009.00466.X","article-title":"Interactions between extracellular matrix and growth factors in wound healing.","volume":"17","author":"Schultz","year":"2009","journal-title":"Wound Repair Regen."},{"key":"2025102819225121300_R47","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/S00441-002-0531-1","article-title":"Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic response.","volume":"308","author":"Sepulcre","year":"2002","journal-title":"Cell Tissue Res."},{"key":"2025102819225121300_R48","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1210\/EN.2002-221035","article-title":"Adhering junction dynamics in the testis are regulated by an interplay of beta 1-integrin and focal adhesion complex-associated proteins.","volume":"144","author":"Siu","year":"2003","journal-title":"Endocrinology"},{"key":"2025102819225121300_R49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbadis.2006.01.010","article-title":"Keratoconus: matrix metalloproteinase-2 activation and TIMP modulation.","volume":"1762","author":"Smith","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"2025102819225121300_R50","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1182\/BLOOD-2006-02-005363","article-title":"Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression.","volume":"108","author":"Stefanidakis","year":"2006","journal-title":"Blood"},{"key":"2025102819225121300_R51","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1074\/MCP.M800181-MCP200","article-title":"Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair.","volume":"8","author":"Stevens","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"2025102819225121300_R52","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0015-0282(97)81388-X","article-title":"Integrins and reproductive physiology: expression and modulation in fertilization, embryogenesis, and implantation.","volume":"67","author":"Sueoka","year":"1997","journal-title":"Fertil. Steril."},{"key":"2025102819225121300_R53","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/J.YGCEN.2004.12.013","article-title":"Ontogeny of the thyroid hormones and cortisol in the gilthead sea bream, Sparus aurata.","volume":"142","author":"Szisch","year":"2005","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025102819225121300_R54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2174\/138920108783497659","article-title":"Joint diseases and matrix metalloproteinases: a role for MMP-13.","volume":"9","author":"Takaishi","year":"2008","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2025102819225121300_R55","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/J.YGCEN.2008.04.006","article-title":"Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development.","volume":"157","author":"Tiago","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"2025102819225121300_R56","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/J.1067-1927.2004.012302.X","article-title":"Extracellular matrix signaling through growth factor receptors during wound healing.","volume":"12","author":"Tran","year":"2004","journal-title":"Wound Repair Regen."},{"key":"2025102819225121300_R57","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/S00441-009-0893-8","article-title":"The developmental roles of the extracellular matrix: beyond structure to regulation.","volume":"339","author":"Tsang","year":"2010","journal-title":"Cell Tissue Res."},{"key":"2025102819225121300_R58","first-page":"506","article-title":"Collagen-receptor signaling in health and disease.","volume":"11","author":"Vogel","year":"2001","journal-title":"Eur. J. Dermatol."},{"key":"2025102819225121300_R59","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/ZEB.2009.0609","article-title":"The zebrafish embryo: a powerful model system for investigating matrix remodeling.","volume":"6","author":"Wyatt","year":"2009","journal-title":"Zebrafish"},{"key":"2025102819225121300_R60","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/S00427-003-0346-4","article-title":"The expression of gelatinase A (MMP-2) is required for normal development of zebrafish embryos.","volume":"213","author":"Zhang","year":"2003","journal-title":"Dev. Genes Evol."},{"key":"2025102819225121300_R61","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1242\/JCS.02921","article-title":"Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of a2\u00df1 integrin.","volume":"119","author":"Zhang","year":"2006","journal-title":"J. Cell Sci."},{"key":"2025102819225121300_R62","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/SJ.JID.5700546","article-title":"Integrin a2\u00df1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization.","volume":"127","author":"Zweers","year":"2007","journal-title":"J. Invest. Dermatol."}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/23\/5\/654\/306969\/rd10351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/23\/5\/654\/306969\/rd10351.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:22:57Z","timestamp":1761693777000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/23\/5\/654\/49590\/Identification-of-a-1-integrin-isoform-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,5]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6,3]]}},"URL":"https:\/\/doi.org\/10.1071\/rd10351","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,5]]}}}