{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:10:47Z","timestamp":1791015047021,"version":"4.1.0"},"reference-count":30,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4890,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,30]]},"abstract":"<jats:p>Antenatal glucocorticoids are administered to mature the fetal lungs before preterm birth. Glucocorticoids also have non-pulmonary effects, including reducing fetal body and brain growth. The present study examined whether glucocorticoid administration has a sex-specific effect on growth in appropriately grown (control) and intrauterine growth-restricted (IUGR) fetal sheep. IUGR was induced at 0.7 gestation in fetal sheep by single umbilical artery ligation. On Days 5 and 6 after surgery, IUGR or control fetuses were exposed to the synthetic glucocorticoid betamethasone (BM; 11.4 mg) or saline via intramuscular maternal administration. On Day 7, a postmortem was conducted to determine fetal sex and weight. Compared with control fetuses, the birthweight of male and female IUGR fetuses was significantly reduced (by 18.5 \u00b1 4.4% (P = 0.002) and 21.7 \u00b1 6.0% (P = 0.001), respectively). Maternal administration of BM significantly reduced bodyweight in both control and IUGR fetuses (by 11.3 \u00b1 2.8% and 20.5 \u00b1 3.6% in control male and female fetuses, respectively; and by 22.9 \u00b1 3.1% and 38.3 \u00b1 3.4% in IUGR male and female fetuses, respectively; P &amp;lt; 0.001 for all, versus control + saline) fetuses. In control and IUGR animals the degree of growth restriction was greater in females than males (P &amp;lt; 0.05) following administration of BM. These data suggest that antenatal glucocorticoids reduce fetal growth in a sex-specific manner, with females more growth restricted than males.<\/jats:p>","DOI":"10.1071\/rd11143","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T04:15:12Z","timestamp":1325823312000},"page":"753-758","source":"Crossref","is-referenced-by-count":28,"title":["Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner"],"prefix":"10.1071","volume":"24","author":[{"given":"Suzanne L.","family":"Miller","sequence":"first","affiliation":[{"name":"AThe Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia."},{"name":"CCorresponding author. Email: graham.jenkin@monash.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"AThe Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena G.","family":"Supramaniam","sequence":"additional","affiliation":[{"name":"BDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Walker","sequence":"additional","affiliation":[{"name":"AThe Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Jenkin","sequence":"additional","affiliation":[{"name":"AThe Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"AThe Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Vic. 3168, Australia."},{"name":"BDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic. 3168, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"key":"2025102819242316500_R1","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1177\/08830738060210070101","article-title":"Role of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injury.","volume":"21","author":"Back","year":"2006","journal-title":"J. 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