{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:17:41Z","timestamp":1778044661740,"version":"3.51.4"},"reference-count":30,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4890,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,30]]},"abstract":"<jats:p>Human and rodent studies indicate a role for circadian rhythmicity and associated clock gene expression in supporting normal parturition. The importance of clock gene expression in tissues besides the suprachiasmatic nucleus is emerging. Here, a Bmal1 conditional knockout mouse line and a novel Cre transgenic mouse line were used to examine the role of myometrial Bmal1 in parturition. Ninety-two percent (22\/24) of control females but only 64% (14\/22) of females with disrupted myometrial Bmal1 completed parturition during the expected time window of 5 p.m. on Day 19 through to 9 a.m. on Day 19.5 of gestation. However, neither serum progesterone levels nor uterine transcript expression of the contractile-associated proteins Connexin43 and Oxytocin receptor differed between females with disrupted myometrial Bmal1 and controls during late gestation. The data indicate a role for myometrial Bmal1 in maintaining normal time of day of parturition.<\/jats:p>","DOI":"10.1071\/rd11164","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T04:15:17Z","timestamp":1325823317000},"page":"759-767","source":"Crossref","is-referenced-by-count":39,"title":["Generation of myometrium-specific Bmal1 knockout mice for parturition analysis"],"prefix":"10.1071","volume":"24","author":[{"given":"Christine K.","family":"Ratajczak","sequence":"first","affiliation":[{"name":"AMolecular Cell Biology Program, Washington University, St Louis, MO 63110, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Asada","sequence":"additional","affiliation":[{"name":"BDepartment of Pediatrics, Washington University, St Louis, MO 63110, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg C.","family":"Allen","sequence":"additional","affiliation":[{"name":"CDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"McMahon","sequence":"additional","affiliation":[{"name":"CDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Muglia","sequence":"additional","affiliation":[{"name":"DDepartments of Molecular Physiology and Biophysics and Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dont\u00e9","family":"Smith","sequence":"additional","affiliation":[{"name":"DDepartments of Molecular Physiology and Biophysics and Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandip","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"DDepartments of Molecular Physiology and Biophysics and Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, TN 37232, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis J.","family":"Muglia","sequence":"additional","affiliation":[{"name":"DDepartments of Molecular Physiology and Biophysics and Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville, TN 37232, USA."},{"name":"ECorresponding author. Email: louis.muglia@vanderbilt.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2012,1,6]]},"reference":[{"issue":"1","key":"2025102819244272700_R1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/0748730407311254","article-title":"The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.","volume":"23","author":"Alvarez","year":"2008","journal-title":"J. Biol. 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