{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:41:46Z","timestamp":1761712906262,"version":"build-2065373602"},"reference-count":36,"publisher":"CSIRO Publishing","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4929,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,30]]},"abstract":"<jats:p>Varicocele is the most common cause of primary male infertility and is associated with oxidative stress. The aim of the present study was to investigate the effects of anthocyanin on a rat model of varicocele. Twenty-four male rats were divided into four experimental groups: a normal control group, a varicocele-induced control group and two varicocele-induced groups treated with either 40 or 80 mg kg\u20131, p.o., anthocyanin for 4 weeks. Varicocele was induced by the partial obstruction of the left renal vein. After 8 weeks, the testes and epididymides from rats in all groups were removed, weighed and subjected to histological examination and semen analysis. Apoptosis in the testes was determined by terminal deoxyribonucleotidyl transferase-mediated dUTP\u2013digoxigenin nick end-labelling (TUNEL) and oxidative stress was assessed by measuring 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels. Although no significant differences in sperm counts were observed among the groups, anthocyanin treatment of the varicocele-induced groups resulted in significantly increased testes weight, sperm motility and spermatogenic cell density (P &amp;lt; 0.05). Anthocyanin treatment also significantly decreased apoptotic body count and 8-OHdG concentrations (P &amp;lt; 0.05). We suggest that the antioxidant effect of anthocyanin prevented the damage caused by varicocele-induced reactive oxygen species.<\/jats:p>","DOI":"10.1071\/rd11174","type":"journal-article","created":{"date-parts":[[2011,11,27]],"date-time":"2011-11-27T17:50:02Z","timestamp":1322416202000},"page":"649-655","source":"Crossref","is-referenced-by-count":24,"title":["Effects of anthocyanin extracted from black soybean seed coat on spermatogenesis in a rat varicocele-induced model"],"prefix":"10.1071","volume":"24","author":[{"given":"Hoon","family":"Jang","sequence":"first","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Mo","family":"Yuk","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Seok","family":"Han","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.-Syn","family":"Ha","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hoo","family":"Hong","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeol","family":"Lee","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Kon","family":"Hwang","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Yeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"BKorea Bio Medical Science Institute, Sinhan Building, Nonhyun-dong 80-1, Kangnam-gu, Seoul 135-010, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"AThe Department of Urology, The Catholic University of Korea College of Medicine, Seoul 137-701, Korea."},{"name":"CCorresponding author. 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