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Maternal, fetal and placental weights were statistically lower in stressed animals than controls, suggesting abnormalities in gestational physiology. Morphologically the placentas of rats subjected to stress were reduced in size and weight, with few glycogen cells and a significant increase in the number of apoptotic cells. Stress caused an increase in placental gene expression of Vegfa (P &amp;lt; 0.05) and a reduction in Pgf, Flt1 and Kdr expression (P &amp;lt; 0.05). It has been suggested that increased VEGF is associated with vasodilatation and hypotension, but in this model persistent hypertension was present. This study suggests that the limited hypotensive Vegfa response to stress-induced hypertension could result from reduced expression of Flt1\/Kdr disrupting specific VEGF pathways. These findings may elucidate one of the multiple possible factors underlying how stress modulates placental physiology, and could aid the understanding of stress-induced gestational disorders.<\/jats:p>","DOI":"10.1071\/rd11202","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T19:01:00Z","timestamp":1328814060000},"page":"851-858","source":"Crossref","is-referenced-by-count":4,"title":["Expression of angiogenic factors in placenta of stressed rats"],"prefix":"10.1071","volume":"24","author":[{"given":"Isis Paloppi","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"ADepartment of Obstetrics and Gynecology, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Ruano","sequence":"additional","affiliation":[{"name":"ADepartment of Obstetrics and Gynecology, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."},{"name":"CCorresponding author. 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