{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:17:35Z","timestamp":1790803055815,"version":"4.1.0"},"reference-count":39,"publisher":"CSIRO Publishing","issue":"7","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4822,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,28]]},"abstract":"<jats:p>The objective of this study was to evaluate fetal weight, histomorphometric changes and proliferative activity, apoptosis and angiogenesis of the placenta in rats with hypothyroidism. Thirty-six adult female rats were divided into two groups with 18 animals each: control and hypothyroidism. Hypothyroidism was induced by daily administration of propylthiouracil (1 mg\/animal). The administration began five days before becoming pregnant and the animals were sacrificed at 14 or 19 days of gestation. The control group received a placebo. The number and weight of fetuses and the rate of fetal death was determined, as well as the morphometric characteristics, the immunohistochemical expression of cell division control protein 47 (CDC)-47 and vascular endothelial growth factor (VEGF) and the number of apoptotic cells in the placental disk. The data were analysed by Mann\u2013Whitney U test. Hypothyroidism reduced the weight of fetuses and of the uterus and placenta (P &amp;lt; 0.05), altered the thickness of the placental labyrinth and spongiotrophoblast (P &amp;lt; 0.05), increased the population of glycogen cells in the spongiotrophoblast (P &amp;lt; 0.05), interfered with the vascular development of the placental labyrinth and decreased VEGF expression (P &amp;lt; 0.05), reduced the expression of CDC-47 and cellularity and increased the apoptotic rate in the placental disk (P &amp;lt; 0.05). We conclude that hypothyroidism affects fetal weight by altering the proliferative activity, apoptosis and vascularisation of the placenta.<\/jats:p>","DOI":"10.1071\/rd11219","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T21:19:33Z","timestamp":1331673573000},"page":"923-931","source":"Crossref","is-referenced-by-count":58,"title":["Fetal growth restriction in hypothyroidism is associated with changes in proliferative activity, apoptosis and vascularisation of the placenta"],"prefix":"10.1071","volume":"24","author":[{"given":"Juneo F.","family":"Silva","sequence":"first","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula N.","family":"Vidigal","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele D.","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jankerle N.","family":"Boeloni","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipe Pimenta","family":"Nunes","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia M.","family":"Ocarino","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernane F.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9ria","family":"Serakides","sequence":"additional","affiliation":[{"name":"ADepartamento de Cl\u00ednica e Cirurgia Veterin\u00e1ria, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais. 31270-901 Belo Horizonte, MG, Brazil."},{"name":"BCorresponding author. 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