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The objectives of the present study were to describe the effects of isobutyl methylxanthine (IBMX), which decreases cAMP degradation, and forskolin, which increases cAMP production, on spontaneous and induced maturation (by equine chorionic gonadotrophin (eCG) and epidermal growth factor (EGF)) of feline oocytes and to evaluate the reversibility of IBMX-induced arrest by measuring the resumption of meiosis and embryonic development following IVF. IBMX decreased (P &amp;lt; 0.05) the incidence of spontaneous (6.7% vs 42.0%, metaphase II (MII)) and induced (5.6% vs 66.1% MII) maturation after 24 h of culture. In contrast, forskolin stimulated meiosis (81.7% MII; P &amp;lt; 0.05). Following 12 h of culture with IBMX and an additional 24 h with eCG and EGF in the absence of IBMX, the proportions of oocytes reaching MII (66.1%), cleaving (79.9%) and developing to the blastocyst stage (15.3%) were similar (P &amp;gt; 0.05) to oocytes cultured continuously with eCG and EGF (70.2%, 83.0% and 18.1%, respectively). These results demonstrate that IBMX reversibly inhibits both spontaneous and eCG+EGF-induced meiosis in feline oocytes without compromising the oocyte\u2019s developmental competence.<\/jats:p>","DOI":"10.1071\/rd12341","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T20:00:42Z","timestamp":1358452842000},"page":"258-267","source":"Crossref","is-referenced-by-count":15,"title":["Reversible meiotic arrest in feline oocytes"],"prefix":"10.1071","volume":"26","author":[{"given":"Jason R.","family":"Herrick","sequence":"first","affiliation":[{"name":"1Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.Present address: National Foundation for Fertility Research, 10290 RidgeGate Cr, Lone Tree, CO 80124, USA. 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