{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:24Z","timestamp":1791326124208,"version":"4.3.1"},"reference-count":51,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":4768,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,17]]},"abstract":"<jats:p>Y-chromosome microdeletions (YCMs) have been found at a much higher rate in infertile men than fertile controls. A specific deletion in the azoospermia factor locus (AZF) at Yq11 is significantly associated with male infertility. Whether assisted reproductive technology (ART) increases the risk of YCM in ART-derived offspring remains unclear. In this study the occurrence of YCM in 199 fathers and their 228 sons (Chinese, Han ethnicity), including 85 offspring conceived by IVF, 73 by intra-cytoplasmic sperm injection (ICSI) and 70 by natural conception, was investigated. Nineteen candidate genes related to YCM were analysed by multiplex ligation-dependent probe amplification. We identified one de novo YCM from 70 naturally-conceived offspring and none from 158 ART-conceived offspring and found no statistical significance between these two groups. There was no statistically-significant difference in the detection rate of the father\u2019s Y-chromosome microdeletion group: IVF 10.7% (8\/75), ICSI 3.2% (2\/63), natural conception 8.2% (5\/61). These results suggest that ART does not increase the risk of YCM in male offspring.<\/jats:p>","DOI":"10.1071\/rd13092","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T20:37:57Z","timestamp":1370896677000},"page":"778-786","source":"Crossref","is-referenced-by-count":7,"title":["ART do not increase the risk of Y-chromosome microdeletion in 19 candidate genes at AZF regions"],"prefix":"10.1071","volume":"26","author":[{"given":"Xiao-Hong","family":"Liu","sequence":"first","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"DBeijing Haidian Maternal and Child Health Hospital, No.33, Haidian South Road, Haidian District, Beijing 100080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Yan","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yan","family":"Jin","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"DBeijing Haidian Maternal and Child Health Hospital, No.33, Haidian South Road, Haidian District, Beijing 100080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"ACenter for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"BKey Laboratory of Assisted Reproduction, Ministry of Education, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"CBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, No. 49, Huayuan North Road, Haidian District, Beijing 100191, China."},{"name":"ECorresponding author. Email: jie.qiao@263.net"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"issue":"9","key":"2026070101450746000_R1","first-page":"680","article-title":"Usefulness of MLPA technique for rapid prenatal detection of aneuploidy. Results of 409 diagnostic studies.","volume":"82","author":"Bocian","year":"2011","journal-title":"Ginekol. Pol."},{"issue":"Suppl. 1","key":"2026070101450746000_R2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/HUMREP\/14.SUPPL_1.243","article-title":"Seven years of intracytoplasmic sperm injection and follow-up of 1987 subsequent children.","volume":"14","author":"Bonduelle","year":"1999","journal-title":"Hum. 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