{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:08:17Z","timestamp":1773943697272,"version":"3.50.1"},"reference-count":43,"publisher":"CSIRO Publishing","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4269,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,8]]},"abstract":"<jats:p>Although several long-acting follicle-stimulating hormone (FSH) therapies have been developed to enhance the ovarian response, a disadvantage of FSH therapy is its relatively short half-life, which requires women to receive one to two injections per day for almost 2 weeks. In the present study, we developed a novel FSH analogue by conjugating recombinant human FSH (rhFSH) and the constant region of the human immunoglobulin G4 fragment via non-peptidyl linkers. The efficacy of the FSH analogue was evaluated in vitro by cAMP level assessments, pharmacokinetic studies and a determination of ovarian weight and by comparing these findings with the results from other FSH analogues. In addition, the total number of antral and Graafian follicles was determined after 7 days of treatment with control, 6 \u00b5g kg\u20131 follitropin \u00df, 6, 12 or 42 \u00b5g kg\u20131 corifollitropin a or 3, 6 or 12 \u00b5g kg\u20131 long acting protein\/peptide discovery-follicle-stimulating hormone (LAPS-FSH). As a result, the animals treated with 12 \u00b5g kg\u20131 LAPS-FSH produced additional and larger healthy follicles. These data demonstrate that LAPS-FSH promotes growth and inhibits atresia of the ovarian follicle compared with other available drugs, suggesting that our new drug enhances the efficacy and duration of treatment. It is expected that our new FSH analogue will result in a higher chance of pregnancy in patients who are unresponsive to other drugs.<\/jats:p>","DOI":"10.1071\/rd13118","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T20:51:54Z","timestamp":1379451114000},"page":"1142-1153","source":"Crossref","is-referenced-by-count":4,"title":["LAPS-FSH: a new and effective long-acting follicle-stimulating hormone analogue for the treatment of infertility"],"prefix":"10.1071","volume":"26","author":[{"given":"Sunyoung","family":"Jung","sequence":"first","affiliation":[{"name":"ADepartment of Pathology, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."},{"name":"BAsan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."},{"name":"DThe authors consider that the first two authors should be regarded as joint first authors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjin","family":"Park","sequence":"additional","affiliation":[{"name":"CHanmi Research Center, Hwaseong-si, Gyeonggi-do, 445-813, Korea."},{"name":"DThe authors consider that the first two authors should be regarded as joint first authors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YoungHoon","family":"Kim","sequence":"additional","affiliation":[{"name":"CHanmi Research Center, Hwaseong-si, Gyeonggi-do, 445-813, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Yon","family":"Kim","sequence":"additional","affiliation":[{"name":"CHanmi Research Center, Hwaseong-si, Gyeonggi-do, 445-813, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Ji","family":"Choi","sequence":"additional","affiliation":[{"name":"ADepartment of Pathology, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."},{"name":"BAsan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo-Chan","family":"Son","sequence":"additional","affiliation":[{"name":"ADepartment of Pathology, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."},{"name":"BAsan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea."},{"name":"ECorresponding authors. 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