{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:13:32Z","timestamp":1783721612751,"version":"3.55.0"},"reference-count":56,"publisher":"CSIRO Publishing","issue":"7","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":4299,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,22]]},"abstract":"<jats:p>Spontaneous preterm birth is usually associated with infection, inflammation or both. Forkhead box (FOX) M1 (FOXM1), a member of the FOX family of transcription factors, has been associated with inflammation. The aim of this study was to determine whether FOXM1 regulates the expression and release of pro-labour mediators in human gestational tissues. FOXM1 mRNA and protein expression were determined in fetal membranes from women at (1) preterm no labour: Caesarean section with no labour and (2) preterm labour: after spontaneous labour and delivery. Primary amnion cells were utilised to investigate the effect of small interfering RNA (siRNA)-mediated gene silencing of FOXM1 on pro-labour mediators. Spontaneous preterm labour decreased FOXM1 gene and nuclear protein expression. FOXM1 silencing in primary amnion cells increased interleukin (IL)-1\u00df-induced pro-inflammatory cytokines (IL-6 and IL-8 mRNA expression and secretion), cyclooxygenase (COX)-2 expression and subsequent prostaglandin (PG)E2 and PGF2a release as well as gene expression and secretion of the matrix-degrading enzyme matrix metalloproteinase 9 (MMP-9). In conclusion, spontaneous preterm labour is associated with decreased FOXM1 expression in fetal membranes.<\/jats:p>","DOI":"10.1071\/rd13140","type":"journal-article","created":{"date-parts":[[2013,8,18]],"date-time":"2013-08-18T20:38:07Z","timestamp":1376858287000},"page":"1052-1060","source":"Crossref","is-referenced-by-count":3,"title":["FOXM1 is lower in human fetal membranes after spontaneous preterm labour and delivery"],"prefix":"10.1071","volume":"26","author":[{"given":"Ratana","family":"Lim","sequence":"first","affiliation":[{"name":"ADepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Vic. 3010, Australia."},{"name":"BMercy Perinatal Research Centre, Mercy Hospital for Women, 4th Floor, 163 Studley Road, Heidelberg, Vic. 3084, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Barker","sequence":"additional","affiliation":[{"name":"ADepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Vic. 3010, Australia."},{"name":"BMercy Perinatal Research Centre, Mercy Hospital for Women, 4th Floor, 163 Studley Road, Heidelberg, Vic. 3084, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Lappas","sequence":"additional","affiliation":[{"name":"ADepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Vic. 3010, Australia."},{"name":"BMercy Perinatal Research Centre, Mercy Hospital for Women, 4th Floor, 163 Studley Road, Heidelberg, Vic. 3084, Australia."},{"name":"CCorresponding author. 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