{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:25:20Z","timestamp":1778757920194,"version":"3.51.4"},"reference-count":68,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":3850,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,18]]},"abstract":"<jats:p>Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with gonadotrophins following human chorionic gonadotrophin (hCG) administration. The relationship between hCG and OHSS is partly mediated via the production of angiogenic factors, such as vascular endothelial growth factor A (VEGFA) and angiopoietins (ANGPTs). Here, we investigated the effect of ANGPT1 inhibition on ovarian angiogenesis in follicular fluid (FF) from women at risk of OHSS, using the chorioallantoic membrane (CAM) of quail embryos as an experimental model. We also analysed cytoskeletal changes and endothelial junction protein expression induced by this FF in the presence or absence of an ANGPT1-neutralising antibody in endothelial cell cultures. The presence of this antibody restored the number of vascular branch points and integrin av\u00df3 levels in the CAMs to control values. ANGPT1 inhibition in FF from OHSS patients also restored the levels of claudin-5, vascular endothelial cadherin and phosphorylated \u00df-catenin and partially reversed actin redistribution in endothelial cells. Our findings suggest that ANGPT1 increases pathophysiological angiogenesis in patients at risk of OHSS by acting on tight and adherens junction proteins. Elucidating the mechanisms by which ANGPT1 regulates vascular development and cell\u2013cell junctions in OHSS will contribute to identifying new therapeutic targets for the treatment of human diseases with aberrant vascular leakage.<\/jats:p>","DOI":"10.1071\/rd13356","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T17:56:30Z","timestamp":1415642190000},"page":"690-699","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)"],"prefix":"10.1071","volume":"28","author":[{"given":"Leopoldina","family":"Scotti","sequence":"first","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."},{"name":"DCorresponding author. Email: leopoldinascotti@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalhia","family":"Abramovich","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Pascuali","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Haro","family":"Durand","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Griselda","family":"Irusta","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"de Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"BCentro M\u00e9dico PREGNA Medicina Reproductiva, Juncal 3490 (1425) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tesone","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."},{"name":"CDepartamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales \u2013 Universidad de Buenos Aires, Intendente G\u00fciraldes 2160 (1428), Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Parborell","sequence":"additional","affiliation":[{"name":"AInstituto de Biolog\u00eda y Medicina Experimental (IByME) \u2013 CONICET, Vuelta de Obligado 2490 (1428) Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"2025102819581543100_R1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1095\/BIOLREPROD.106.051052","article-title":"Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotrophin-treated prepubertal rats.","volume":"75","author":"Abramovich","year":"2006","journal-title":"Biol. 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