{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:23:46Z","timestamp":1789950226299,"version":"4.0.1"},"reference-count":38,"publisher":"CSIRO Publishing","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":3666,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:p>The effects of adoptive transfer of transforming growth factor (TGF)-\u00df1-induced regulatory T (Treg) cells in preventing spontaneous abortion in mice were investigated. CD4+CD25\u2013 cells were isolated from the spleens of pregnant CBA\/J mice and induced into Treg cells positive for CD4, CD25 and forkhead box P3 (FOXP3) ex vivo using interleukin (IL)-2 and TGF-\u00df1. CBA\/J mice were mated with DBA\/2J mice to establish a model of spontaneous abortion and, on the first day of pregnancy, mice were injected intravenously with 2 \u00d7 105 either freshly isolated Treg cells or those induced with TGF-\u00df1. After 14 days, the surviving and reabsorbed fetuses in both groups were counted, and serum cytokine concentrations were measured by ELISA. Adoptive transfer of CD4+CD25+ or TGF-\u00df1-induced Treg cells significantly reduced the fetal resorption rate, increased serum IL-10 and TGF-\u00df1 concentrations and decreased interferon-? levels. In conclusion, the results of the present study indicate that adoptive transfer of TGF-\u00df1-induced Treg cells prevents spontaneous abortion in mice by increasing the secretion of T helper (Th) 2 cytokines and decreasing the secretion of Th1 cytokines.<\/jats:p>","DOI":"10.1071\/rd14503","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T18:38:06Z","timestamp":1431542286000},"page":"1788-1797","source":"Crossref","is-referenced-by-count":9,"title":["Adoptive transfer of transforming growth factor-\u00df1-induced CD4+CD25+ regulatory T cells prevents immune response-mediated spontaneous abortion"],"prefix":"10.1071","volume":"28","author":[{"given":"Tian","family":"Qiu","sequence":"first","affiliation":[{"name":"ADepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, 600 Yishan Road, Shanghai 200233, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yincheng","family":"Teng","sequence":"additional","affiliation":[{"name":"ADepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, 600 Yishan Road, Shanghai 200233, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[{"name":"BDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, 910 Hengshan Road, Shanghai 200030, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"BDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, 910 Hengshan Road, Shanghai 200030, China."},{"name":"CCorresponding author. 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