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In this study, we investigated the effects of in vivo D-Asp administration in two major regions of the rat epididymis (Region I: initial segment, caput, corpus; Region II: cauda). The results suggest that exogenous D-Asp was taken up by both regions of rat epididymis. D-Asp administration induced a rapid increase in T, followed by a more gradual decrease in the T : DHT ratio in Region I. In Region II, T levels rapidly decreased and the T : DHT ratio was consistently lower relative to the control. Expression of 5a-red and androgen receptor genes showed a good correlation with DHT levels in both regions. D-Asp treatment also induced an increase of both E2 levels and oestradiol receptor-a (ERa) expression in Region I, whereas neither E2 levels nor ERa expression were affected in Region II. The early increase of P450-aro expression in Region I and late increase in Region II suggests a direct involvement of D-Asp modulation in P450-aro gene expression. Our results suggest that D-Asp modulates androgen and oestrogen levels and expression of androgen and oestrogen receptors in the rat epididymis by acting on the expression of 5a-red and P450-aro genes.<\/jats:p>","DOI":"10.1071\/rd15092","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T21:27:57Z","timestamp":1433453277000},"page":"1865-1872","source":"Crossref","is-referenced-by-count":28,"title":["Androgen and oestrogen modulation by D-aspartate in rat epididymis"],"prefix":"10.1071","volume":"28","author":[{"given":"S.","family":"Falvo","sequence":"first","affiliation":[{"name":"ADipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universit\u00e0 di Napoli, Via Vivaldi 43, 81100, Caserta, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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