{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:57:40Z","timestamp":1782917860016,"version":"3.54.5"},"reference-count":57,"publisher":"CSIRO Publishing","issue":"12","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":4024,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,11]]},"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF) is expressed extensively in the mammalian female reproductive system and has been implicated in the development of follicles and oocytes. However, BDNF expression patterns in the ovary and its effects on oocyte maturation and embryonic development in polycystic ovary syndrome (PCOS) have not been established. In the present study, we established a PCOS model by treating the rats with insulin and human chorionic gonadotropin (hCG). Rats treated with insulin + hCG had heavier bodyweight and ovarian weight, higher circulating concentrations of luteinising hormone (LH) and testosterone (T), and greater homeostatic model assessment of insulin resistance (HOMA-IR) values compared with control rats (P &amp;lt; 0.05). BDNF and its receptor tyrosine kinase type B (TrkB) were located in cyst walls, granulosa and theca cells, and BDNF protein levels were lower in ovaries of insulin + hCG-treated rats (P &amp;lt; 0.05). The rate of oocyte maturation and formation of blastocysts and morulae was greatest in rats treated with 5 ng mL\u20131 BDNF (P &amp;lt; 0.05) compared to other BDNF groups (1 and 10 ng mL\u20131) and the control. The control rats were also PCOS rats and were treated without BDNF. There were no significant differences in the rate of germinal vesicle breakdown (GVBD) and fertilisation among the various treatment groups (1, 5 and 10 ng mL\u20131) and the control group (P &amp;gt; 0.05). The results indicate that in vitro treatment with an appropriate concentration of BDNF not only promotes oocyte maturation, but also rescues embryonic development in rats treated with insulin + hCG as a model of PCOS.<\/jats:p>","DOI":"10.1071\/rd15131","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T01:28:48Z","timestamp":1435195728000},"page":"1904-1915","source":"Crossref","is-referenced-by-count":13,"title":["Effects of brain-derived neurotrophic factor on oocyte maturation and embryonic development in a rat model of polycystic ovary syndrome"],"prefix":"10.1071","volume":"28","author":[{"given":"Qiaoli","family":"Zhang","sequence":"first","affiliation":[{"name":"AShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Lingshan Road 845, Shanghai 200135, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"BDepartment of Obstetrics and Gynecology, The Second Hospital of Tianjin Medical University, Pingjiang Road 23, Tianjin 300211, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"AShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Lingshan Road 845, Shanghai 200135, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"CDepartment of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Yanta West Road 277, Xi\u2019an 710061, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Lu","sequence":"additional","affiliation":[{"name":"DDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Yanta West Road 277, Xi\u2019an 710061, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Du","sequence":"additional","affiliation":[{"name":"AShanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Lingshan Road 845, Shanghai 200135, China."},{"name":"FCorresponding author. 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