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The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto\u2013placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA. Furthermore, fetuses in the SC group had significantly higher biparietal and thoracic diameters and longer crown\u2013rump lengths than fetuses in Group R. Hence, the SC group had a reduced IUGR rate and a higher kit size at birth compared with Group R. In conclusion, SC may provide potential benefits in pregnancies with placental insufficiency and IUGR, partially counteracting the negative effects of food restriction on placental development and fetal growth. However, the present study also found evidence of a possible blood overflow in the brain that warrants further investigation.<\/jats:p>","DOI":"10.1071\/rd15330","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T11:38:24Z","timestamp":1464003504000},"page":"1239-1248","source":"Crossref","is-referenced-by-count":23,"title":["The effects of sildenafil citrate on feto\u2013placental development and haemodynamics in a rabbit model of intrauterine growth restriction"],"prefix":"10.1071","volume":"29","author":[{"given":"Jorge","family":"L\u00f3pez-Tello","sequence":"first","affiliation":[{"name":"ADepartment of Animal Production, Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Arias-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"ADepartment of Animal Production, Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-\u00c1ngeles","family":"Jim\u00e9nez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"BDepartment of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Barbero-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"BDepartment of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CDepartment of Physiology (Animal Physiology), Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"DDepartment of Animal Production, Polytechnic University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro L.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"CDepartment of Physiology (Animal Physiology), Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Torres-Rovira","sequence":"additional","affiliation":[{"name":"ADepartment of Animal Production, Veterinary Faculty, Complutense University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Astiz","sequence":"additional","affiliation":[{"name":"EComparative Physiology Lab, SGIT-INIA, Avda, Puerta de Hierro, s\/n, 28040, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gonz\u00e1lez-Bulnes","sequence":"additional","affiliation":[{"name":"EComparative Physiology Lab, SGIT-INIA, Avda, Puerta de Hierro, s\/n, 28040, Madrid, Spain."},{"name":"FDepartment of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100, Sassari, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar G.","family":"Rebollar","sequence":"additional","affiliation":[{"name":"DDepartment of Animal Production, Polytechnic University of Madrid, Ciudad Universitaria, s\/n, 28040, Madrid, Spain."},{"name":"GCorresponding author. 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