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The male offspring born to obese mothers and fed an HCD after weaning were found to be obese. Seminiferous tubules of offspring from control mothers (OCM) and offspring from HCD-fed mothers (OHCDM) had the same set of germ cells at different age intervals, namely spermatogonia, leptotene spermatocytes, zygotene spermatocytes, pachytene spermatocytes and round and elongated spermatids on postnatal days (PND) 7, 13, 17, 24 and 36, and on the day of preputial separation, respectively. However, there was a significant decrease in round and elongated spermatids and the epididymal sperm count, coupled with a significant decrease in testosterone and an increase in leptin serum concentrations in OHCDM compared with OCM. These results show that obesity in prepubertal rats does not affect the age-dependent appearance of germ cells according to developmental hierarchy, but it does interfere with spermatid formation, resulting in a reduced sperm count, which may be due to a deficiency of testosterone mediated by hyperleptinaemia.<\/jats:p>","DOI":"10.1071\/rd15480","type":"journal-article","created":{"date-parts":[[2016,2,14]],"date-time":"2016-02-14T22:36:42Z","timestamp":1455489402000},"page":"815-823","source":"Crossref","is-referenced-by-count":9,"title":["Obesity causes weight increases in prepubertal and pubertal male offspring and is related to changes in spermatogenesis and sperm production in rats"],"prefix":"10.1071","volume":"29","author":[{"given":"Harish","family":"Navya","sequence":"first","affiliation":[{"name":"ADepartment of Zoology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanumant Narasinhacharya","family":"Yajurvedi","sequence":"additional","affiliation":[{"name":"ADepartment of Zoology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India."},{"name":"BCorresponding author. 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