{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:25:47Z","timestamp":1790702747569,"version":"4.1.0"},"reference-count":76,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":3303,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,18]]},"abstract":"<jats:p>Fipronil is an insecticide widely used in agriculture, veterinary medicine and public health that has recently been listed as a potential endocrine disrupter. In the present study we evaluated the effects of perinatal exposure to fipronil during the period of sexual brain differentiation and its later repercussions on reproductive parameters in male rats. Pregnant rats were exposed (via gavage) to fipronil (0.03, 0.3 or 3 mg kg\u20131) from Gestational Day 15 until Postnatal Day 7. Fipronil exposure did not compromise the onset of puberty. In adulthood, there was no effect on organ weight or sperm production. Furthermore, there were no adverse effects on the number of Sertoli cells per seminiferous tubule, testicular and epididymal histomorphometry or histopathology or expression patterns of androgen receptor in the testis. Similarly, no changes were observed in the sexual behaviour or hormone levels. However, in rats exposed to fipronil, changes in sperm motility were observed, with a decrease in motile spermatozoa and an increase in non-mobile spermatozoa, which can compromise sperm quality in these rats. Perinatal exposure to fipronil has long-term effects on sperm parameters, and the epididymis can be a target organ. Additional studies should be undertaken to identify the mechanisms by which fipronil affects sperm motility.<\/jats:p>","DOI":"10.1071\/rd15517","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T21:37:40Z","timestamp":1462916260000},"page":"1130-1143","source":"Crossref","is-referenced-by-count":23,"title":["Perinatal exposure to insecticide fipronil: effects on the reproductive system in male rats"],"prefix":"10.1071","volume":"29","author":[{"given":"Aline L.","family":"de Barros","sequence":"first","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H.","family":"Bae","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele S.","family":"Borges","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane L.","family":"Rosa","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia M.","family":"Cavariani","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia V.","family":"Silva","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia F. F.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"BDepartment of Anatomy, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP), Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janete A.","family":"Anselmo-Franci","sequence":"additional","affiliation":[{"name":"CDepartment of Morphology, Estomatology and Physiology, Dental School of Ribeirao Preto, University of Sao Paulo-FORP\/USP, Av. do Cafe, s\/n, Monte Alegre, Ribeir\u00e3o Preto, S\u00e3o Paulo State, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle C.","family":"Arena","sequence":"additional","affiliation":[{"name":"ADepartment of Morphology, Institute of Biosciences of Botucatu, S\u00e3o Paulo State University, (UNESP) \u2013 Distrito de Rubi\u00e3o Junior s\/n, 510 \u2013 Botucatu, S\u00e3o Paulo State, Brazil."},{"name":"DCorresponding author. Email: ariellearena@ibb.unesp.br"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"2025102819144962500_R1","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1172\/JCI115392","article-title":"Rapid alteration in circulating free thyroxine modulates pituitary type II 5deiodinase and basal thyrotropin secretion in the rat.","volume":"88","author":"Abend","year":"1991","journal-title":"J. Clin. Invest."},{"key":"2025102819144962500_R2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1385-299X(96)00036-0","article-title":"Male rat sexual behavior.","volume":"1","author":"\u00c5gmo","year":"1997","journal-title":"Brain Res. Protoc."},{"key":"2025102819144962500_R3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1530\/JRF.0.0730441","article-title":"Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocytes.","volume":"73","author":"Aitken","year":"1985","journal-title":"J. Reprod. Fertil."},{"key":"2025102819144962500_R4","unstructured":"Agencia Nacional de Vigil\u00e2ncia Sanit\u00e1ria (ANVISA). (2005). \u00cdndice Monogr\u00e1fico. F43 Fipronil. Dispon\u00edvel. Available at http:\/\/www4.anvisa.gov.br\/base\/visadoc\/CP\/CP%5B9774-1-0%5D.PDF [verified 23 February 2013]."},{"key":"2025102819144962500_R5","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1080\/15287390802392024","article-title":"Fenvalerate, a pyrethroid insecticide, adversely affects sperm production and storage in male rats.","volume":"71","author":"Arena","year":"2008","journal-title":"J. Toxicol. Environ. Health A"},{"key":"2025102819144962500_R6","doi-asserted-by":"publisher","first-page":"8059","DOI":"10.1073\/PNAS.131016298","article-title":"Excitatory versus inhibitory GABA as a divergence point in steroid-mediated sexual differentiation of the brain.","volume":"98","author":"Auger","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025102819144962500_R7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/ETC.2041","article-title":"Enantio selective toxicity and bioaccumulation of fipronil in fathead minnows (Pimephales promelas) following water and sediment exposure.","volume":"32","author":"Baird","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"2025102819144962500_R8","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0015-0282(16)56171-8","article-title":"Prognostic significance of computerized motility analysis for in vivo fertility.","volume":"60","author":"Barratt","year":"1993","journal-title":"Fertil. Steril."},{"key":"2025102819144962500_R9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1289\/EHP.10700","article-title":"Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.","volume":"116","author":"Bonde","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"2025102819144962500_R10","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/S0015-0282(16)54012-6","article-title":"Fertility prognosis for infertile men from two different population evaluated by the Cox regression model.","volume":"54","author":"Bostofte","year":"1990","journal-title":"Fertil. Steril."},{"key":"2025102819144962500_R11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0018-506X(91)90005-3","article-title":"Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations.","volume":"25","author":"Brand","year":"1991","journal-title":"Horm. Behav."},{"key":"2025102819144962500_R12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1089\/DNA.2013.2158","article-title":"In vitro genotoxicity of fipronil sister chromatid exchange, cytokinesis block micronucleus test, and comet assay.","volume":"33","author":"\u00c7elik","year":"2014","journal-title":"DNA Cell Biol."},{"key":"2025102819144962500_R13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/J.MCE.2006.04.036","article-title":"Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty.","volume":"254\u2013255","author":"Clarkson","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"2025102819144962500_R14"},{"key":"2025102819144962500_R15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/BDRB.10041","article-title":"Evaluation of testicular toxicology: a synopsis and discussion of the recommendations proposed by the society of toxicologic pathology.","volume":"68","author":"Creasy","year":"2003","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"2025102819144962500_R16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/J.ETP.2010.11.015","article-title":"Genotoxic and mutagenic effects of fipronil on mice.","volume":"64","author":"de Oliveira","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"2025102819144962500_R17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/J.ENVINT.2015.07.017","article-title":"Human exposure to endocrine disrupting chemicals and fertility: a case-control study in male subfertility patients.","volume":"84","author":"Den Hond","year":"2015","journal-title":"Environ. Int."},{"key":"2025102819144962500_R18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1530\/REP.1.00367","article-title":"The neuroendocrine timing of puberty.","volume":"129","author":"Ebling","year":"2005","journal-title":"Reproduction"},{"key":"2025102819144962500_R19"},{"key":"2025102819144962500_R20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/J.REPROTOX.2006.09.002","article-title":"Reproductive effects in male rats exposed to diuron.","volume":"23","author":"Fernandes","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"2025102819144962500_R21"},{"key":"2025102819144962500_R22","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1289\/EHP.0901084","article-title":"Dioxin-induced changes in epididymal sperm count and spermatogenesis.","volume":"118","author":"Foster","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"2025102819144962500_R23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-800095-3.00001-8","article-title":"Endocrine-disrupting chemicals and human growth and maturation: a focus on early critical windows of exposure.","volume":"94","author":"Fudvoye","year":"2014","journal-title":"Vitam. Horm."},{"key":"2025102819144962500_R24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0890-6238(99)00036-2","article-title":"Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights.","volume":"13","author":"Gallavan","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"2025102819144962500_R25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/J.ANIREPROSCI.2004.05.011","article-title":"Post-testicular sperm environment and fertility.","volume":"82\u201383","author":"Gatti","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"2025102819144962500_R26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/J.PHYSBEH.2004.10.014","article-title":"Sexual behavior, neuroendocrine, and neurochemical aspects in male rats exposed prenatally to stress.","volume":"84","author":"Gerardin","year":"2005","journal-title":"Physiol. Behav."},{"key":"2025102819144962500_R27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/DEV.20570","article-title":"Alterations of sex-typical microanatomy: prenatal stress modifies the structure of medial preoptic area neurons in rats.","volume":"54","author":"Gerecke","year":"2012","journal-title":"Dev. Psychobiol."},{"key":"2025102819144962500_R28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.14310\/HORM.2002.1249","article-title":"Neuroendocrine targets of endocrine disruptors.","volume":"9","author":"Gore","year":"2010","journal-title":"Hormones (Athens)"},{"key":"2025102819144962500_R29","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1006\/TAAP.1999.8752","article-title":"Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.","volume":"160","author":"Hood","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2025102819144962500_R30","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1289\/EHP.98106437","article-title":"Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents.","volume":"106","author":"Hurley","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"2025102819144962500_R31"},{"key":"2025102819144962500_R32","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1152\/JN.01234.2006","article-title":"Dorsal unpaired median neurons of Locusta migratoria express ivermectin and fipronil-sensitive glutamate-gated chloride channels.","volume":"97","author":"Janssen","year":"2007","journal-title":"J. Neurophysiol."},{"key":"2025102819144962500_R33","first-page":"301","article-title":"Human exposure to fipronil from dogs treated with Frontline.","volume":"44","author":"Jennings","year":"2002","journal-title":"Vet. Hum. Toxicol."},{"key":"2025102819144962500_R34","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/0028-3908(83)90111-9","article-title":"Behavioral analogues of anxiety. Animal models.","volume":"22","author":"Lal","year":"1983","journal-title":"Neuropharmacology"},{"key":"2025102819144962500_R35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/J.1439-0272.1996.TB02766.X","article-title":"Effects of guanethidine-induced sympathectomy on the spermatogenic and steroidogenic testicular functions of prepubertal to mature rats.","volume":"28","author":"Lamano-Carvalho","year":"1996","journal-title":"Andrologia"},{"key":"2025102819144962500_R36","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/J.TALANTA.2007.04.061","article-title":"Transfer assessment of fipronil residues from feed to cow milk.","volume":"73","author":"Le Faouder","year":"2007","journal-title":"Talanta"},{"key":"2025102819144962500_R37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/AJA.1000900202","article-title":"Spermiogenesis of rat, mouse, hamster and guinea pig as revealed by the periodic acid-Fuchs in sulfurous acid technique.","volume":"90","author":"Leblond","year":"1952","journal-title":"Am. J. Anat."},{"key":"2025102819144962500_R38","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/J.TOX.2008.09.026","article-title":"Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes.","volume":"255","author":"Leghait","year":"2009","journal-title":"Toxicology"},{"key":"2025102819144962500_R39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/J.CHEMOSPHERE.2014.07.015","article-title":"Endocrine disrupting potential of fipronil and its metabolite in reporter gene assays.","volume":"120","author":"Lu","year":"2015","journal-title":"Chemosphere"},{"key":"2025102819144962500_R40","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1126\/SCIENCE.6163211","article-title":"Sexual differentiation of the central nervous system.","volume":"211","author":"MacLusky","year":"1981","journal-title":"Science"},{"key":"2025102819144962500_R41","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0015-0282(16)48080-5","article-title":"The influence of seminal characteristics on the success rate of human in vitro fertilization.","volume":"42","author":"Mahadevan","year":"1984","journal-title":"Fertil. Steril."},{"key":"2025102819144962500_R42","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0166-2236(02)02182-3","article-title":"Getting excited about GABA and sex differences in the brain.","volume":"25","author":"McCarthy","year":"2002","journal-title":"Trends Neurosci."},{"key":"2025102819144962500_R43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/J.REPROTOX.2010.08.004","article-title":"Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity.","volume":"30","author":"Monje","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"2025102819144962500_R44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1177\/074823379901500107","article-title":"Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat.","volume":"15","author":"Monosson","year":"1999","journal-title":"Toxicol. Ind. Health"},{"key":"2025102819144962500_R45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1530\/JRF.0.0780093","article-title":"Relationship between human sperm motility characteristics and sperm penetration into human cervical mucus in vitro.","volume":"78","author":"Mortimer","year":"1986","journal-title":"J. Reprod. Fertil."},{"key":"2025102819144962500_R46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/J.PESTBP.2009.07.008","article-title":"Glutamate-activated chloride channels: unique fipronil targets present in insects but not in mammals.","volume":"97","author":"Narahashi","year":"2010","journal-title":"Pestic. Biochem. Physiol."},{"key":"2025102819144962500_R47","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/J.JSBMB.2008.03.003","article-title":"Sexual differentiation of the rodent hypothalamus: hormonal and environmental influences.","volume":"109","author":"Negri-Cesi","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2025102819144962500_R48","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1006\/RTPH.1997.1149","article-title":"Vulnerability of the endocrine system to xenobiotic influence.","volume":"26","author":"Neubert","year":"1997","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"2025102819144962500_R49","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1210\/EN.2009-1333","article-title":"Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis.","volume":"151","author":"O\u2019Shaughnessy","year":"2010","journal-title":"Endocrinology"},{"key":"2025102819144962500_R50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/J.TOXLET.2003.08.008","article-title":"Reproductive adverse effects of fipronil in Wistar rats.","volume":"146","author":"Ohi","year":"2004","journal-title":"Toxicol. Lett."},{"key":"2025102819144962500_R51","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/J.REPROTOX.2006.04.017","article-title":"Impairment of adult male reproductive function in rats exposed to ethanol since puberty.","volume":"22","author":"Oliva","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"2025102819144962500_R52","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/J.BRAINRESREV.2007.06.008","article-title":"Influence of endocrine active compounds on the developing rodent brain.","volume":"57","author":"Patisaul","year":"2008","journal-title":"Brain Res. Rev."},{"key":"2025102819144962500_R53","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1016\/J.LFS.2005.10.035","article-title":"Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?","volume":"78","author":"Pereira","year":"2006","journal-title":"Life Sci."},{"key":"2025102819144962500_R54","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1080\/15287391003751802","article-title":"Decreased sperm motility in rats orally exposed to single or mixed pesticides.","volume":"73","author":"Perobelli","year":"2010","journal-title":"J. Toxicol. Environ. Health A"},{"key":"2025102819144962500_R55","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/J.PHYSBEH.2009.05.003","article-title":"Adult partner preference and sexual behavior of male rats exposed prenatally to betamethasone.","volume":"98","author":"Piffer","year":"2009","journal-title":"Physiol. Behav."},{"key":"2025102819144962500_R56","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/J.PBB.2005.08.015","article-title":"5Alpha-reductase 2 inhibition impairs brain defeminization of male rats: reproductive aspects.","volume":"82","author":"Ribeiro","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2025102819144962500_R57"},{"key":"2025102819144962500_R58","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1530\/JRF.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of puberal and adult rats.","volume":"54","author":"Robb","year":"1978","journal-title":"J. Reprod. Fertil."},{"key":"2025102819144962500_R59","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1111\/J.1471-4159.2008.05384.X","article-title":"Steroid-induced sexual differentiation of the developing brain: multiple pathways, one goal.","volume":"105","author":"Schwarz","year":"2008","journal-title":"J. Neurochem."},{"key":"2025102819144962500_R60","first-page":"624","article-title":"The laboratory rat: relating its age with human\u2019s.","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"2025102819144962500_R61","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1177\/0960327113515504","article-title":"Environmental toxins: alarming impacts of pesticides on male fertility.","volume":"33","author":"Sengupta","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"key":"2025102819144962500_R62","first-page":"663","article-title":"Is perinatal picrotoxin anxigenic?","volume":"28","author":"Silva","year":"1995","journal-title":"Braz. J. Med. Biol. Res."},{"key":"2025102819144962500_R63","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0091-3057(97)00582-0","article-title":"Perinatal treatment with picrotoxin induces sexual, behavioral, and neuroendocrine changes in male rats.","volume":"60","author":"Silva","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2025102819144962500_R64","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/J.PESTBP.2010.12.007","article-title":"Behavioral effects of acute exposure to the insecticide fipronil.","volume":"99","author":"Ter\u00e7ariol","year":"2011","journal-title":"Pestic. Biochem. Physiol."},{"key":"2025102819144962500_R65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4899-7283-5_1","article-title":"Fipronil: environmental fate, ecotoxicology, and humam health concerns.","volume":"176","author":"Tingle","year":"2003","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"2025102819144962500_R66","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/J.NTT.2014.05.010","article-title":"Prenatal exposure to a low fipronil dose disturbs maternal behavior and reflex development in rats.","volume":"45","author":"Udo","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"2025102819144962500_R67","unstructured":"United States Environmental Protection Agency (2015). \u2018Reduced risk and organophosphate alternative decisions for conventional pesticides.\u2019 Available at https:\/\/www.epa.gov\/pesticide-registration\/reduced-risk-and-organophosphate-alternative-decisions-conventional [verified 18 April 2016]"},{"key":"2025102819144962500_R68","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1006\/HBEH.1995.1014","article-title":"Sexual preference and feminine and masculine sexual behavior of male rats prenatally exposed to antiandrogen or antiestrogen.","volume":"29","author":"Vega Matuszczyk","year":"1995","journal-title":"Horm. Behav."},{"key":"2025102819144962500_R69","doi-asserted-by":"publisher","first-page":"e104639","DOI":"10.1371\/JOURNAL.PONE.0104639","article-title":"Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.","volume":"9","author":"Viluksela","year":"2014","journal-title":"PLoS One"},{"key":"2025102819144962500_R70","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1210\/endo.134.5.8156934","article-title":"Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis.","volume":"134","author":"Vornberger","year":"1994","journal-title":"Endocrinology"},{"key":"2025102819144962500_R71","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1210\/ER.2008-0025","article-title":"Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice.","volume":"30","author":"Wang","year":"2009","journal-title":"Endocr. Rev."},{"key":"2025102819144962500_R72","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs.","volume":"12","author":"Weibel","year":"1963","journal-title":"Lab. Invest."},{"key":"2025102819144962500_R73","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0027-5107(95)00138-7","article-title":"Mechanisms and pathogenesis of thyroid cancer in animals and man.","volume":"333","author":"Williams","year":"1995","journal-title":"Mutat. Res."},{"key":"2025102819144962500_R74","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/J.REPROTOX.2004.08.006","article-title":"Reproductive and sexual behavior changes in male rats exposed perinatally to picrotoxin.","volume":"19","author":"Yasuhara","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"2025102819144962500_R75"},{"key":"2025102819144962500_R76","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1124\/JPET.104.065516","article-title":"Fipronil is a potent open channel blocker of glutamate-activated chloride channels in cockroach neurons.","volume":"310","author":"Zhao","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/29\/6\/1130\/305560\/rd15517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/29\/6\/1130\/305560\/rd15517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:14:54Z","timestamp":1761693294000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/29\/6\/1130\/49333\/Perinatal-exposure-to-insecticide-fipronil-effects"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5,18]]}},"URL":"https:\/\/doi.org\/10.1071\/rd15517","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}