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After 21 days SR (18 h per day), epididymides were collected on Postnatal Day (PND) 62 for evaluation of oxidative stress markers, inflammatory profile, sperm count and histopathological and stereological analyses; in addition, the motility of spermatozoa from the vas deferens was examined. SR significantly increased lipid peroxidation and glutathione levels in the caput and cauda epididymidis, and increased levels of total radical-trapping antioxidant potential in the caput epididymidis only. Neutrophil migration to the caput or corpus epididymidis was decreased by SR, and the size of the luminal compartment in the 2A region and the epithelial compartment in the 5A\/B region was also decreased. In these regions, there was an increase in the size of the interstitial compartment. The percentage of immotile spermatozoa was higher in the SR group. In conclusion, SR affects epididymal postnatal development, as well as sperm motility, in association with increased oxidative stress and a decrease in the size of the epithelial compartment in the cauda epididymidis.<\/jats:p>","DOI":"10.1071\/rd15535","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T23:12:25Z","timestamp":1477437145000},"page":"1813-1820","source":"Crossref","is-referenced-by-count":12,"title":["Sleep restriction in Wistar rats impairs epididymal postnatal development and sperm motility in association with oxidative stress"],"prefix":"10.1071","volume":"29","author":[{"given":"Gl\u00e1ucia E. M. 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