{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:39:10Z","timestamp":1790163550006,"version":"4.1.0"},"reference-count":61,"publisher":"CSIRO Publishing","issue":"12","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2904,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,31]]},"abstract":"<jats:p>The aim of the present study was to compare serum leptin, kisspeptin, total adiponectin, high molecular weight (HMW) adiponectin and neuropeptide Y (NPY) levels between girls with central precocious puberty (CPP; n = 26, 7\u20139.5 years old) and age-matched controls (n = 29) including or excluding obese girls. Leptin and NPY levels were comparable between CPP and control girls. Kisspeptin levels were lower in the CPP than control group, and were positively correlated with oestrogen in the control group and with systolic and diastolic blood pressure in the CPP group. Kisspeptin levels were negatively correlated with FSH and LH in the CPP group. Total adiponectin levels were lower in CPP than control girls, and were negatively correlated with Tanner stage and body mass index, but positively correlated with the quantitative insulin sensitivity check index in the control group. HMW adiponectin was higher in the CPP than control group, and was positively correlated with Tanner stage and LH in all girls. Total adiponectin had a strong positive correlation with HMW adiponectin in the CPP group (r = 0.915) compared with the control group (r = 0.371). In conclusion, kisspeptin may be associated with increased oestrogen in prepubertal girls, but with increased blood pressure in girls with CPP. In girls entering puberty, HMW adiponectin was increased and associated with reproductive parameters. Based on these observations, HMW adiponectin probably plays an essential role in the initiation of puberty and is a candidate marker for the prediction of CPP.<\/jats:p>","DOI":"10.1071\/rd16282","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T21:36:44Z","timestamp":1497389804000},"page":"2466-2478","source":"Crossref","is-referenced-by-count":11,"title":["Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls"],"prefix":"10.1071","volume":"29","author":[{"given":"Chantacha","family":"Sitticharoon","sequence":"first","affiliation":[{"name":"ADepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand."},{"name":"CCorresponding author. Email: chantacha.sit@mahidol.ac.th"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maynart","family":"Sukharomana","sequence":"additional","affiliation":[{"name":"ADepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawadee","family":"Likitmaskul","sequence":"additional","affiliation":[{"name":"BDepartment of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Churintaraphan","sequence":"additional","affiliation":[{"name":"ADepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pailin","family":"Maikaew","sequence":"additional","affiliation":[{"name":"ADepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"2025102819294025500_R1","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.2337\/DB05-1525","article-title":"Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin.","volume":"55","author":"Aso","year":"2006","journal-title":"Diabetes"},{"key":"2025102819294025500_R2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1080\/09513590410001712866","article-title":"Is neuropeptide Y responsible for constitutional delay of puberty in girls? A preliminary report.","volume":"19","author":"Blogowska","year":"2004","journal-title":"Gynecol. Endocrinol."},{"key":"2025102819294025500_R3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1080\/14767050600762131","article-title":"Body composition and concentrations of leptin, neuropeptide Y, beta-endorphin, growth hormone, insulin-like growth factor-I and insulin at menarche in girls with constitutional delay of puberty.","volume":"22","author":"Blogowska","year":"2006","journal-title":"Gynecol. Endocrinol."},{"key":"2025102819294025500_R4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.2337\/DC06-1362","article-title":"Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays.","volume":"30","author":"Bl\u00fcher","year":"2007","journal-title":"Diabetes Care"},{"key":"2025102819294025500_R5","doi-asserted-by":"publisher","first-page":"E1100","DOI":"10.1152\/AJPENDO.00187.2006","article-title":"Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes.","volume":"291","author":"Bodles","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025102819294025500_R6","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.1210\/JC.2004-0303","article-title":"Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels.","volume":"89","author":"B\u00f6ttner","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025102819294025500_R7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1530\/REP-10-0119","article-title":"Obesity and the pubertal transition in girls and boys.","volume":"140","author":"Burt Solorzano","year":"2010","journal-title":"Reproduction"},{"key":"2025102819294025500_R8","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1210\/EN.2007-0554","article-title":"Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes.","volume":"148","author":"Caraty","year":"2007","journal-title":"Endocrinology"},{"key":"2025102819294025500_R9","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1056\/NEJMCP0800459","article-title":"Clinical practice. Precocious puberty.","volume":"358","author":"Carel","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"2025102819294025500_R10","doi-asserted-by":"publisher","first-page":"4852","DOI":"10.1210\/EN.2006-0117","article-title":"Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?","volume":"147","author":"Castellano","year":"2006","journal-title":"Endocrinology"},{"key":"2025102819294025500_R11","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/J.FERTNSTERT.2012.02.021","article-title":"Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract.","volume":"97","author":"Cejudo Roman","year":"2012","journal-title":"Fertil. Steril."},{"key":"2025102819294025500_R12","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/J.FERTNSTERT.2008.09.008","article-title":"Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells.","volume":"92","author":"Chabrolle","year":"2009","journal-title":"Fertil. Steril."},{"key":"2025102819294025500_R13","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.2337\/DIABETES.54.7.1914","article-title":"Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model.","volume":"54","author":"Chen","year":"2005","journal-title":"Diabetes"},{"key":"2025102819294025500_R14","doi-asserted-by":"publisher","first-page":"e58698","DOI":"10.1371\/JOURNAL.PONE.0058698","article-title":"Leptin signaling in Kiss1 neurons arises after pubertal development.","volume":"8","author":"Cravo","year":"2013","journal-title":"PLoS One"},{"key":"2025102819294025500_R15","doi-asserted-by":"publisher","first-page":"10714","DOI":"10.1073\/PNAS.0704114104","article-title":"Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.","volume":"104","author":"d\u2019Anglemont de Tassigny","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025102819294025500_R16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents.","volume":"85","author":"de Onis","year":"2007","journal-title":"Bull. World Health Organ."},{"key":"2025102819294025500_R17","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/PNAS.1834399100","article-title":"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.","volume":"100","author":"de Roux","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025102819294025500_R18","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/J.1365-2265.2009.03575.X","article-title":"Kisspeptin serum levels in girls with central precocious puberty.","volume":"71","author":"De Vries","year":"2009","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"2025102819294025500_R19","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1210\/JC.2005-1468","article-title":"Kisspeptin-54 stimulates the hypothalamic\u2013pituitary gonadal axis in human males.","volume":"90","author":"Dhillo","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025102819294025500_R20","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1172\/JCI45106","article-title":"Leptin\u2019s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons.","volume":"121","author":"Donato","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025102819294025500_R21","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/J.BBRC.2003.11.066","article-title":"The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system.","volume":"312","author":"Funes","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025102819294025500_R22","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1210\/JC.2004-0518","article-title":"Adiponectin: a novel adipokine linking adipocytes and vascular function.","volume":"89","author":"Goldstein","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025102819294025500_R23","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1210\/EN.2004-0431","article-title":"A role for kisspeptins in the regulation of gonadotropin secretion in the mouse.","volume":"145","author":"Gottsch","year":"2004","journal-title":"Endocrinology"},{"key":"2025102819294025500_R24","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1210\/ER.2005-0005","article-title":"Adiponectin and adiponectin receptors.","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"issue":"Suppl. 3","key":"2025102819294025500_R25","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1542\/PEDS.2007-1813F","article-title":"Link between body fat and the timing of puberty.","volume":"121","author":"Kaplowitz","year":"2008","journal-title":"Pediatrics"},{"key":"2025102819294025500_R26","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1210\/EN.2009-1198","article-title":"Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors.","volume":"151","author":"Klenke","year":"2010","journal-title":"Endocrinology"},{"key":"2025102819294025500_R27","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1210\/EN.2013-1677","article-title":"Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.","volume":"155","author":"Klenke","year":"2014","journal-title":"Endocrinology"},{"key":"2025102819294025500_R28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/J.1463-1326.2008.00909.X","article-title":"DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue.","volume":"11","author":"Kos","year":"2009","journal-title":"Diabetes Obes. Metab."},{"key":"2025102819294025500_R29","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1210\/EN.2007-0078","article-title":"Kiss1\n            -\/- mice exhibit more variable hypogonadism than Gpr54-\/- mice.","volume":"148","author":"Lapatto","year":"2007","journal-title":"Endocrinology"},{"key":"2025102819294025500_R30","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1210\/ME.2007-0330","article-title":"Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes.","volume":"22","author":"Lu","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"2025102819294025500_R31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1161\/HYPERTENSIONAHA.108.118133","article-title":"Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.","volume":"53","author":"Ma","year":"2009","journal-title":"Hypertension"},{"key":"2025102819294025500_R32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1477-7827-8-23","article-title":"Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development.","volume":"8","author":"Maillard","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2025102819294025500_R33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1161\/HYPERTENSIONAHA.108.110320","article-title":"Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease.","volume":"53","author":"Mathieu","year":"2009","journal-title":"Hypertension"},{"key":"2025102819294025500_R34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/J.BBRC.2004.05.185","article-title":"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat.","volume":"320","author":"Matsui","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025102819294025500_R35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1210\/EN.2006-0818","article-title":"Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels.","volume":"148","author":"Mead","year":"2007","journal-title":"Endocrinology"},{"key":"2025102819294025500_R36","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1073\/PNAS.0409330102","article-title":"Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.","volume":"102","author":"Messager","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025102819294025500_R37","doi-asserted-by":"publisher","first-page":"E965","DOI":"10.1152\/AJPENDO.00119.2007","article-title":"Detection of adiponectin in cerebrospinal fluid in humans.","volume":"293","author":"Neumeier","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025102819294025500_R38","doi-asserted-by":"publisher","first-page":"9073","DOI":"10.1074\/JBC.M207198200","article-title":"Structure\u2013function studies of the adipocyte-secreted hormone Acrp30\/adiponectin. Implications for metabolic regulation and bioactivity.","volume":"278","author":"Pajvani","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025102819294025500_R39","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1530\/EJE.1.01978","article-title":"The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals.","volume":"153","author":"Peake","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"2025102819294025500_R40","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/J.FERTNSTERT.2012.12.008","article-title":"Kisspeptin stimulates progesterone secretion via the Erk1\/2 mitogen-activated protein kinase signaling pathway in rat luteal cells.","volume":"99","author":"Peng","year":"2013","journal-title":"Fertil. Steril."},{"key":"2025102819294025500_R41","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1210\/EN.2007-1365","article-title":"Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol.","volume":"149","author":"Pielecka-Fortuna","year":"2008","journal-title":"Endocrinology"},{"key":"2025102819294025500_R42","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/J.PEPTIDES.2011.07.016","article-title":"Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty.","volume":"32","author":"Pita","year":"2011","journal-title":"Peptides"},{"key":"2025102819294025500_R43","first-page":"957","article-title":"Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases.","volume":"5","author":"Pons","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"2025102819294025500_R44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0167-0115(00)00130-0","article-title":"Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors.","volume":"95","author":"Pralong","year":"2000","journal-title":"Regul. Pept."},{"key":"2025102819294025500_R45","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000151396","article-title":"Expression of adiponectin and adiponectin receptors in human pituitary gland and brain.","volume":"89","author":"Psilopanagioti","year":"2009","journal-title":"Neuroendocrinology"},{"key":"2025102819294025500_R46","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/NM1029","article-title":"Adiponectin acts in the brain to decrease body weight.","volume":"10","author":"Qi","year":"2004","journal-title":"Nat. Med."},{"key":"2025102819294025500_R47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/J.DOMANIEND.2006.04.004","article-title":"Molecular cloning and tissue expression of chicken AdipoR1 and AdipoR2 complementary deoxyribonucleic acids.","volume":"33","author":"Ramachandran","year":"2007","journal-title":"Domest. Anim. Endocrinol."},{"key":"2025102819294025500_R48","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1210\/ENDO.140.9.6985","article-title":"Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype.","volume":"140","author":"Raposinho","year":"1999","journal-title":"Endocrinology"},{"key":"2025102819294025500_R49","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3346\/JKMS.2011.26.7.927","article-title":"Serum kisspeptin levels in Korean girls with central precocious puberty.","volume":"26","author":"Rhie","year":"2011","journal-title":"J. Korean Med. Sci."},{"key":"2025102819294025500_R50","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/J.FERTNSTERT.2012.04.050","article-title":"Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility and early embryo development in the mouse and human.","volume":"98","author":"Richards","year":"2012","journal-title":"Fertil. Steril."},{"key":"2025102819294025500_R51","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1111\/J.1471-4159.2007.04899.X","article-title":"Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells.","volume":"103","author":"Rosmaninho-Salgado","year":"2007","journal-title":"J. Neurochem."},{"key":"2025102819294025500_R52","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/J.YHBEH.2013.01.014","article-title":"Metabolic control of puberty: roles of leptin and kisspeptins.","volume":"64","author":"Sanchez-Garrido","year":"2013","journal-title":"Horm. Behav."},{"key":"2025102819294025500_R53","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1056\/NEJMOA035322","article-title":"The GPR54 gene as a regulator of puberty.","volume":"349","author":"Seminara","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2025102819294025500_R54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2337\/DIABETES.55.01.06.DB05-1077","article-title":"Adiponectin does not cross the blood\u2013brain barrier but modifies cytokine expression of brain endothelial cells.","volume":"55","author":"Spranger","year":"2006","journal-title":"Diabetes"},{"key":"2025102819294025500_R55","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1507\/ENDOCRJ.K10E-077","article-title":"The role of gut hormones and the hypothalamus in appetite regulation.","volume":"57","author":"Suzuki","year":"2010","journal-title":"Endocr. J."},{"key":"2025102819294025500_R56","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/J.1365-2826.2004.01240.X","article-title":"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic\u2013pituitary\u2013gonadal axis.","volume":"16","author":"Thompson","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"2025102819294025500_R57","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/J.BCP.2014.07.018","article-title":"Natural product agonists of peroxisome proliferator-activated receptor gamma (PPAR?): a review.","volume":"92","author":"Wang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"2025102819294025500_R58","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1210\/JC.2002-020590","article-title":"Pubertal and gender-related changes in the sympathoadrenal system in healthy children.","volume":"87","author":"Weise","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025102819294025500_R59","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/J.BBRC.2008.04.146","article-title":"Globular adiponectin inhibits GnRH secretion from GT1\u20137 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential.","volume":"371","author":"Wen","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025102819294025500_R60","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1530\/JOE-12-0054","article-title":"Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1\u20137 neurons.","volume":"214","author":"Wen","year":"2012","journal-title":"J. Endocrinol."},{"key":"2025102819294025500_R61","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1038\/OBY.2005.260","article-title":"Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity.","volume":"13","author":"Woo","year":"2005","journal-title":"Obes. Res."}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/29\/12\/2466\/308307\/rd16282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/29\/12\/2466\/308307\/rd16282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:29:50Z","timestamp":1761694190000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/29\/12\/2466\/49735\/Increased-high-molecular-weight-adiponectin-but"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,10,31]]}},"URL":"https:\/\/doi.org\/10.1071\/rd16282","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}