{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:10:24Z","timestamp":1785345024702,"version":"3.55.0"},"reference-count":16,"publisher":"CSIRO Publishing","issue":"10","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":3060,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,6]]},"abstract":"<jats:p>Mitochondrial ferritin (FtMt) is a functional ferritin targeted to mitochondria that is highly expressed in the testis. To investigate the role of FtMt in the testis we set up a series of controlled matings between FtMt gene-deletion mice (FtMt\u2013\/\u2013) with FtMt+\/+ mice. We found that the number of newborns per litter and the fertility rate were strongly reduced for the FtMt\u2013\/\u2013 males, but not for the females, indicating that FtMt has an important role for male fertility. The morphology of the testis and of the spermatozoa of FtMt\u2013\/\u2013 mice was normal and we did not detect alterations in sperm parameters or in oxidative stress indices. In contrast, we observed that the cauda epididymides of FtMt\u2013\/\u2013 mice were significantly lighter and contained a lower number of spermatozoa compared with the controls. Also, the ATP content of FtMt\u2013\/\u2013 spermatozoa was found to be lower than that of FtMt+\/+ spermatozoa. These data show that FtMt contributes to sperm epididymis maturation and to male fertility.<\/jats:p>","DOI":"10.1071\/rd16348","type":"journal-article","created":{"date-parts":[[2017,1,8]],"date-time":"2017-01-08T17:44:39Z","timestamp":1483897479000},"page":"2005-2010","source":"Crossref","is-referenced-by-count":19,"title":["Mitochondrial ferritin deficiency reduces male fertility in mice"],"prefix":"10.1071","volume":"29","author":[{"given":"Federica","family":"Maccarinelli","sequence":"first","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Regoni","sequence":"additional","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Carmona","sequence":"additional","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Poli","sequence":"additional","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther G.","family":"Meyron-Holtz","sequence":"additional","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."},{"name":"BLaboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, 32000 Haifa, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Arosio","sequence":"additional","affiliation":[{"name":"AMolecular Biology Laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123 Brescia, Italy."},{"name":"CCorresponding author. 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