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In the present study, we used molecular biology techniques (real-time quantitative polymerase chain reaction), classical immunohistochemical staining coupled with confocal microscopy and proteomic analysis (multiple reaction monitoring and western blot analysis) to investigate the role of four growth factors in embryo\u2013uterine interactions during blastocyst development. Supported by a validated embryo transfer model, the study investigated: (1) the expression of stem cell factor (SCF), stanniocalcin-1 (STC1), connective tissue growth factor (CTGF) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) in bovine uterine fluid; (2) the presence of SCF, STC1, CTGF and HB-EGF mRNA and protein in the bovine endometrium and embryos; and (3) the existence of reciprocal regulation between endometrial and embryonic expression of SCF, STC1, CTGF and HB-EGF. The results suggest that these growth factors most likely play an important role during preimplantation embryo development in cattle. The information obtained from the present study can contribute to improving the performance of in vitro culture technology in cattle and other species.<\/jats:p>","DOI":"10.1071\/rd16383","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T22:50:09Z","timestamp":1487890209000},"page":"2127-2139","source":"Crossref","is-referenced-by-count":11,"title":["Localisation of stem cell factor, stanniocalcin-1, connective tissue growth factor and heparin-binding epidermal growth factor in the bovine uterus at the time of blastocyst formation"],"prefix":"10.1071","volume":"29","author":[{"given":"M.","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"ACentro de Biotecnolog\u00eda Animal, Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario (SERIDA), Camino de Rioseco 1225, 33394 Gij\u00f3n, Spain."},{"name":"ECorresponding author. Email: mmunoz@serida.org"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Martin","sequence":"additional","affiliation":[{"name":"ACentro de Biotecnolog\u00eda Animal, Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario (SERIDA), Camino de Rioseco 1225, 33394 Gij\u00f3n, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Carrocera","sequence":"additional","affiliation":[{"name":"ACentro de Biotecnolog\u00eda Animal, Servicio Regional de Investigaci\u00f3n y Desarrollo Agroalimentario (SERIDA), Camino de Rioseco 1225, 33394 Gij\u00f3n, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alonso-Guervos","sequence":"additional","affiliation":[{"name":"BUnidad de Microscop\u00eda Fot\u00f3nica y Proceso de Im\u00e1genes, Servicios Cient\u00edfico T\u00e9cnicos, Universidad de Oviedo, Instituto Universitario de Oncolog\u00eda de Asturias (IUOPA), 33006, Oviedo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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