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The aim of the present study was to evaluate the effects of PG in feed-restricted heifers on follicular fluid insulin and insulin-like growth factor (IGF) 1 concentrations, expression of IGF system genes in oocytes and cumulus cells and the expression of selected genes in blastocysts. Feed-restricted (R) heifers were drenched with water or PG during induced oestrous cycles (400 mL of PG or water\/drench, daily drenching at 1600 hours for the first 9 days of the oestrous cycle). Ovum pick-up (OPU) was performed after superovulation to produce in vitro embryos and without superovulation to recover oocytes, cumulus cells and follicular fluid. OPU was also performed in a control group (not feed restricted and no drenching). Follicular fluid IGF1 concentrations were reduced by R, and PG restored IGF1 concentrations to those seen in the control group. In cumulus cells, expression of IGF1, IGF1 receptor (IGF1R) and IGF binding protein 4 (IGFBP4) was decreased in the R group, and fully (IGF1 and IGF1R) or partially (IGFBP4) restored to control levels by PG. Blastocyst perilipin 2 (PLIN2; also known as adipophilin), Bcl-2-associated X protein (BAX), SCL2A1 (facilitated glucose\/fructose transporter GLUT1), aquaporin 3 (AQP3), DNA (cytosine-5)-methyltransferase 3A (DNMT3A) and heat shock 70-kDa protein 9 (HSPA9B) expression were decreased in R heifers; PG restored the expression of the last four genes to control levels. In conclusion, these results suggest that, during follicular growth, PG exerts epigenetic regulatory effects on gene expression in blastocyst stage embryos.<\/jats:p>","DOI":"10.1071\/rd17037","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T19:27:06Z","timestamp":1503257226000},"page":"417-429","source":"Crossref","is-referenced-by-count":7,"title":["Oral propylene glycol modifies follicular fluid and gene expression profiles in cumulus\u2013oocyte complexes and embryos in feed-restricted heifers"],"prefix":"10.1071","volume":"30","author":[{"given":"G.","family":"Gamarra","sequence":"first","affiliation":[{"name":"AALLICE, D\u00e9partement Recherche et D\u00e9veloppement, 78350 Jouy en Josas, France."},{"name":"BAURIVA, 64230 Denguin, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ponsart","sequence":"additional","affiliation":[{"name":"CANSES, Animal Health Laboratory, 94706 Maisons-Alfort, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lacaze","sequence":"additional","affiliation":[{"name":"BAURIVA, 64230 Denguin, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nuttinck","sequence":"additional","affiliation":[{"name":"DINRA, UMR 1198 Biologie du D\u00e9veloppement et Reproduction, 78350 Jouy-en-Josas, France."},{"name":"HUniversit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, UMR 1198 Biologie du D\u00e9veloppement et Reproduction, 94704 Maisons-Alfort cedex, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cordova","sequence":"additional","affiliation":[{"name":"EINRA, UMR 7247 Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mermillod","sequence":"additional","affiliation":[{"name":"EINRA, UMR 7247 Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Marquant-Le Guienne","sequence":"additional","affiliation":[{"name":"AALLICE, D\u00e9partement Recherche et D\u00e9veloppement, 78350 Jouy en Josas, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Monniaux","sequence":"additional","affiliation":[{"name":"FINRA, UMR 85 Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Humblot","sequence":"additional","affiliation":[{"name":"GDivision of Reproduction, Department of Clinical Sciences, Faculty of Veterinary Medicine and Agricultural Sciences, SLU, PO Box 7054, SE 75007, Uppsala, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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