{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:08:30Z","timestamp":1761714510461,"version":"build-2065373602"},"reference-count":97,"publisher":"CSIRO Publishing","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2560,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,3]]},"abstract":"<jats:p>High-fat diets (HFDs) are an acknowledged risk factor for male subfertility, but the underlying mechanisms remain unclear. In the present study we compared the effects of two HFDs with different ?6 : ?3 ratios, one enriched with soy oil (SOD; ?6 : ?3 = 9.62) and another enriched with sunflower oil (SFOD; ?6 : ?3 = 51.55), with those of a commercial diet (CD; ?6 : ?3 = 19.87), supplied from pregnancy to adulthood, on morphometric parameters and reproductive performance in adult male mice (recommended ?6 : ?3 for rodents = 1\u20136). Bodyweight was significantly higher in the SFOD than CD group, and relative testicular weight was significantly lower in the SFOD than the other two groups. SFOD altered sperm performance: it reduced sperm viability (mean \u00b1 s.e.m.; 76.00 \u00b1 1.35% vs 82.50 \u00b1 1.45% and 80.63 \u00b1 1.00% in the SFOD vs CD and SOD groups respectively; P &amp;lt; 0.05) and increased the percentage of immature spermatozoa (71.88 \u00b1 7.17% vs 51.38 \u00b1 5.87% and 48.00 \u00b1 5.72% in the SFOD vs CD and SOD groups respectively; P &amp;lt; 0.05). The epididymal ?6 : ?3 ratio was higher in the SFOD versus CD and SOD groups, whereas the unsaturation index was higher in the SOD and SFOD groups than in CD group. Sperm membrane integrity was diminished in both the SOD and SFOD groups, but there was no difference in sperm reactive oxygen species production in these two groups compared with the CD group. The fertilisation rate was lower in the SFOD compared with the CD and SOD groups. In conclusion, although both HFDs affected sperm quality, the fertilising ability was more altered by the excessive dietary ?6 : ?3 ratio than by the net ?6 content.<\/jats:p>","DOI":"10.1071\/rd17552","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T19:42:06Z","timestamp":1527104526000},"page":"1491-1502","source":"Crossref","is-referenced-by-count":2,"title":["Maternal and postnatal high-fat diets with high ?6 : ?3 ratios affect the reproductive performance of male offspring in the mouse"],"prefix":"10.1071","volume":"30","author":[{"given":"S.","family":"Bianconi","sequence":"first","affiliation":[{"name":"AInstituto y C\u00e1tedra de Fisiolog\u00eda Humana, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Santa Rosa 1085, X5000ESU \u2013 C\u00f3rdoba, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Stutz","sequence":"additional","affiliation":[{"name":"AInstituto y C\u00e1tedra de Fisiolog\u00eda Humana, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Santa Rosa 1085, X5000ESU \u2013 C\u00f3rdoba, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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