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Exogenous melatonin, administered via subcutaneous implants, is used to prolong the breeding season of ewes and can increase the proportion of pregnant ewes (fertility rate) and litter size. The increased proportion of ewes that become pregnant and the number of lambs born per lambing among melatonin-treated sheep may be caused by increased embryo survival, through enhanced luteal function, reduced antiluteolytic mechanisms, or improved embryo quality. This review focuses on the effects of melatonin on embryo viability and summarises the processes by which this hormone affects the ovary, follicle, oocyte, corpus luteum and embryo. Moreover, the effects of melatonin on the mechanisms of in vivo maternal recognition of pregnancy in sheep and the protective action that it appears to have on the in vitro procedures that are used to obtain healthy embryos are reviewed.<\/jats:p>","DOI":"10.1071\/rd18308","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T17:26:46Z","timestamp":1543771606000},"page":"82-92","source":"Crossref","is-referenced-by-count":34,"title":["Role of melatonin on embryo viability in sheep"],"prefix":"10.1071","volume":"31","author":[{"given":"Jos\u00e9-Alfonso","family":"Abecia","sequence":"first","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."},{"name":"CCorresponding author. Email: alf@unizar.es"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Forcada","sequence":"additional","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Isabel","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"BDepartamento de Reproducci\u00f3n Animal, Facultad de Agronom\u00eda y Veterinaria, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36, Km 601, 5800 R\u00edo Cuarto, C\u00f3rdoba, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Mui\u00f1o-Blanco","sequence":"additional","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Cebri\u00e1n-P\u00e9rez","sequence":"additional","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaura","family":"P\u00e9rez-Pe","sequence":"additional","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Casao","sequence":"additional","affiliation":[{"name":"AInstituto Universitario de Investigaci\u00f3n en Ciencias Ambientales de Arag\u00f3n (IUCA), Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet, 177, 50013 Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"2025102819530934500_R1","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S0093-691X(99)00212-5","article-title":"A preliminary report on the effect of dietary energy on prostaglandin F-2 alpha production in vitro, interferon-tau synthesis by the conceptus, endometrial progesterone concentration on Days 9 and 15 of pregnancy and associated rates of embryo wastage in ewes.","volume":"52","author":"Abecia","year":"1999","journal-title":"Theriogenology"},{"key":"2025102819530934500_R2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1023\/A:1014099719034","article-title":"The effect of melatonin on the secretion of progesterone in sheep and on the development of ovine embryos in vitro.","volume":"26","author":"Abecia","year":"2002","journal-title":"Vet. 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