{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:49:28Z","timestamp":1768834168022,"version":"3.49.0"},"reference-count":29,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2251,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,8]]},"abstract":"<jats:p>Cytokines are the main factors involved in the normal functions of the placenta and delivery process. The aim of this project was to compare serum levels of interleukin-8 (IL-8), IL-6, tumour necrosis factor a (TNF-a) and transforming growth factor \u00df (TGF-\u00df) in term and prolonged-pregnancy mothers and their neonates. This study was performed on 240 participants including 60 term and prolonged-pregnancy neonates and their corresponding mothers. Serum levels of IL-8, IL-6, TNF-a and TGF-\u00df were evaluated by the enzyme-linked immunosorbent assay technique. The results revealed that IL-8 serum levels were significantly lower in the prolonged-pregnancy mothers and their neonates when compared with term mothers and their neonates. Data analysis also revealed a negative correlation between TGF-\u00df and age of prolonged-pregnancy mothers. A poor positive correlation between IL-6 and head circumference of term neonates was also observed. IL-8 may play crucial roles in the process of on-time delivery and age may significantly affect TGF-\u00df production in prolonged-pregnancy mothers. Pro-inflammatory cytokines, such as IL-6, can also be considered as main factors involved in fetal growth.<\/jats:p>","DOI":"10.1071\/rd18361","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T23:09:43Z","timestamp":1553814583000},"page":"1049-1056","source":"Crossref","is-referenced-by-count":17,"title":["Role of maternal interleukin-8 (IL-8) in normal-term birth in the human"],"prefix":"10.1071","volume":"31","author":[{"given":"Vahid","family":"Ehsani","sequence":"first","affiliation":[{"name":"AImmunology of Infectious Diseases Research Centre, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-7230","authenticated-orcid":true,"given":"Maryam","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"AImmunology of Infectious Diseases Research Centre, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran."},{"name":"BDepartment of Gynaecology and Obstetrics, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, 7719617996, Iran."},{"name":"JCorresponding author. 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