{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:40:48Z","timestamp":1774690848565,"version":"3.50.1"},"reference-count":72,"publisher":"CSIRO Publishing","issue":"9","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2216,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,12]]},"abstract":"<jats:p>Contraception is increasingly used to manage breeding opportunities in conservation-dependent species. This study aimed to determine the efficacy, duration of effect, optimal dose and potential side effects of Suprelorin contraceptive implants in Tasmanian devils, for use in the conservation breeding program. In our pilot study, Suprelorin was found to effectively suppress oestrous cycles in female devils, yet caused a paradoxical increase in testosterone in males. Therefore, we focussed on females in further trials. Females received one (n = 5), two (n = 5) or no (n = 5) Suprelorin implants, with quarterly gonadotrophin-releasing hormone (GnRH) challenges used to test pituitary responsiveness over two breeding seasons. Both Suprelorin doses suppressed pituitary responsiveness for at least one breeding season, with a reduced effect in the second. There was a dose-response effect on duration rather than magnitude of effect, with high-dose devils remaining suppressed for longer than low-dose animals. There were no apparent negative effects on general health, yet captivity and contraception together may cause weight gain. Suprelorin contraceptive implants are now routinely used in the Save the Tasmanian Devil Program insurance metapopulation to meet the aims of maintaining genetic and behavioural integrity by controlling individual reproductive contributions in group housing situations.<\/jats:p>","DOI":"10.1071\/rd18407","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T01:14:08Z","timestamp":1556846048000},"page":"1473-1485","source":"Crossref","is-referenced-by-count":3,"title":["Contraceptive efficacy and dose-response effects of the gonadotrophin-releasing hormone (GnRH) agonist deslorelin in Tasmanian devils (Sarcophilus harrisii)"],"prefix":"10.1071","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-5238","authenticated-orcid":true,"given":"Holly R.","family":"Cope","sequence":"first","affiliation":[{"name":"ASchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, J.D. Stewart Building B01, Camperdown, NSW 2006, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Peck","sequence":"additional","affiliation":[{"name":"BWildlife Management Branch, Department of Primary Industries, Parks, Water and Environment, Hobart, Tas. 7000, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Hobbs","sequence":"additional","affiliation":[{"name":"CTaronga Institute of Science and Learning, Taronga Conservation Society, NSW 2088, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Keeley","sequence":"additional","affiliation":[{"name":"DSchool of Agriculture and Food Sciences, Faculty of Science, The University of Queensland, Gatton, Qld 4343, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Izzard","sequence":"additional","affiliation":[{"name":"BWildlife Management Branch, Department of Primary Industries, Parks, Water and Environment, Hobart, Tas. 7000, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yeen-Yap","sequence":"additional","affiliation":[{"name":"EHobart, Tas. 7000, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"White","sequence":"additional","affiliation":[{"name":"FSydney School of Veterinary Science, Faculty of Science, The University of Sydney, R.M.C. Gunn Building B19, Camperdown, NSW 2006, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J.","family":"Hogg","sequence":"additional","affiliation":[{"name":"ASchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, J.D. Stewart Building B01, Camperdown, NSW 2006, Australia."},{"name":"GZoo and Aquarium Association Australasia, Mosman, NSW 2088, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Herbert","sequence":"additional","affiliation":[{"name":"ASchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, J.D. Stewart Building B01, Camperdown, NSW 2006, Australia."},{"name":"HCorresponding author. Email: catherine.herbert@sydney.edu.au"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"issue":"3","key":"2025102819543276400_R1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4995\/WRS.2010.8190","article-title":"Fertility control in a male rabbit using a deslorelin implant. A case report.","volume":"18","author":"Arlt","year":"2010","journal-title":"World Rabbit Sci."},{"key":"2025102819543276400_R2"},{"key":"2025102819543276400_R3"},{"key":"2025102819543276400_R4","unstructured":"AZA RMC (2016). AZA Reproductive Management Centre. https:\/\/www.stlzoo.org\/animals\/scienceresearch\/reproductivemanagementcenter [Accessed 5 April 2016]"},{"key":"2025102819543276400_R5","unstructured":"AZA RMC (2018). Suprelorin (deslorelin). https:\/\/www.stlzoo.org\/animals\/scienceresearch\/reproductivemanagementcenter\/contraceptionrecommendatio\/contraceptionmethods\/suprelorin-deslorelin [Accessed 15 March 2018]"},{"issue":"4","key":"2025102819543276400_R6","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1095\/BIOLREPROD54.4.769","article-title":"Continued desensitization of the pituitary gland in young bulls after treatment with the luteinizing hormone-releasing hormone agonist deslorelin.","volume":"54","author":"Bergfeld","year":"1996","journal-title":"Biol. Reprod."},{"key":"2025102819543276400_R7","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/J.THERIOGENOLOGY.2017.10.047","article-title":"Effects of deslorelin implants on reproduction and feeding behavior in Tasmanian devils (Sarcophilus harrisii) housed in free-range enclosures.","volume":"107","author":"Cope","year":"2018","journal-title":"Theriogenology"},{"issue":"3","key":"2025102819543276400_R8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/COBI.13042","article-title":"A role for selective contraception of individuals in conservation management programs.","volume":"32","author":"Cope","year":"2018","journal-title":"Conserv. Biol."},{"issue":"2","key":"2025102819543276400_R9","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1647\/2013-027","article-title":"Inhibition of the reproductive system by deslorelin in male and female pigeons (Columba livia).","volume":"28","author":"Cowan","year":"2014","journal-title":"J. Avian Med. Surg."},{"issue":"23","key":"2025102819543276400_R10","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1016\/J.VACCINE.2007.03.033","article-title":"Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive.","volume":"25","author":"Curtis","year":"2007","journal-title":"Vaccine"},{"issue":"1","key":"2025102819543276400_R11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1095\/BIOLREPROD54.1.45","article-title":"Characteristics of luteinizing hormone (LH) and testosterone secretion, pituitary responses to LH-releasing hormone (LHRH), and reproductive function in young bulls receiving the LHRH agonist deslorelin: effect of castration on LH responses to LHRH.","volume":"54","author":"D\u2019Occhio","year":"1996","journal-title":"Biol. Reprod."},{"issue":"1","key":"2025102819543276400_R12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0031-9384(95)02246-5","article-title":"Testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus.","volume":"60","author":"Delville","year":"1996","journal-title":"Physiol. Behav."},{"issue":"8","key":"2025102819543276400_R13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1071\/RD07046","article-title":"Effects of deslorelin implants on reproduction in the common brushtail possum (Trichosurus vulpecula).","volume":"19","author":"Eymann","year":"2007","journal-title":"Reprod. Fertil. Dev."},{"issue":"5","key":"2025102819543276400_R14","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/JHERED\/ESX030","article-title":"Pedigree analysis reveals a generational decline in reproductive success of captive Tasmanian devil (Sarcophilus harrisii): implications for captive management of threatened species.","volume":"108","author":"Farquharson","year":"2017","journal-title":"J. Hered."},{"issue":"9","key":"2025102819543276400_R15","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1177\/1098612X15594990","article-title":"Long-term contraception in a small implant: a review of Suprelorin (deslorelin) studies in cats.","volume":"17","author":"Fontaine","year":"2015","journal-title":"J. Feline Med. Surg."},{"issue":"5","key":"2025102819543276400_R16","first-page":"720","article-title":"Treatment of leiomyomata uteri with leuprolide acetate depot: a double-blind, placebo-controlled, multicenter study.","volume":"77","author":"Friedman","year":"1991","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"2025102819543276400_R17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/WSB.17","article-title":"Health effects of GnRH immunocontraception of wild white-tailed deer in New Jersey.","volume":"35","author":"Gionfriddo","year":"2011","journal-title":"Wildl. Soc. Bull."},{"issue":"5","key":"2025102819543276400_R18","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/J.THERIOGENOLOGY.2010.10.020","article-title":"Clinical efficacy of a GnRH-agonist implant containing 4.7 mg deslorelin, Suprelorin\u00ae, regarding suppression of reproductive function in tomcats.","volume":"75","author":"Goericke-Pesch","year":"2011","journal-title":"Theriogenology"},{"issue":"1","key":"2025102819543276400_R19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/J.THERIOGENOLOGY.2013.03.010","article-title":"Basal testosterone concentrations after the application of a slow-release GnRH agonist implant are associated with a loss of response to buserelin, a short-term GnRH agonist, in the tom cat.","volume":"80","author":"Goericke-Pesch","year":"2013","journal-title":"Theriogenology"},{"issue":"3","key":"2025102819543276400_R20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/ZOO.1022","article-title":"A versatile enzyme immunoassay for the determination of progestogens in feces and serum.","volume":"20","author":"Graham","year":"2001","journal-title":"Zoo Biol."},{"issue":"4","key":"2025102819543276400_R21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/ZOO.10051","article-title":"Enzyme-immunoassay for the measurement of luteinizing hormone in the serum of African elephants (Loxodonta africana).","volume":"21","author":"Graham","year":"2002","journal-title":"Zoo Biol."},{"issue":"1","key":"2025102819543276400_R22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1071\/ZO9700063","article-title":"Observations on the Tasmanian devil, Sarcophilus harrisii (Marsupialia: Dasyuridae) II. Reproduction, breeding and growth of pouch young.","volume":"18","author":"Guiler","year":"1970","journal-title":"Aust. J. Zool."},{"key":"2025102819543276400_R23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.26749\/rstpp.112.161","article-title":"Observations on the Tasmanian devil, Sarcophilus harrisii (Dasyuridae: Marsupialia) at Granville Harbour, 1966\u201375.","volume":"112","author":"Guiler","year":"1978","journal-title":"Royal Society of Tasmania"},{"key":"2025102819543276400_R24","unstructured":"Herbert, C. A. (2002). Contraception of marsupials using slow release implants containing the GnRH agonist deslorelin. Ph.D. Thesis, Macquarie University, Sydney."},{"issue":"6","key":"2025102819543276400_R25","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1095\/BIOLREPROD.103.025122","article-title":"Effects of a gonadotropin-releasing hormone agonist implant on reproduction in a male marsupial, Macropus eugenii.","volume":"70","author":"Herbert","year":"2004","journal-title":"Biol. Reprod."},{"issue":"3","key":"2025102819543276400_R26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1530\/REP.1.00432","article-title":"Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii).","volume":"129","author":"Herbert","year":"2005","journal-title":"Reproduction"},{"issue":"1","key":"2025102819543276400_R27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1071\/WR04113","article-title":"Fertility control in female eastern grey kangaroos using the GnRH agonist deslorelin. 1. Effects on reproduction.","volume":"33","author":"Herbert","year":"2006","journal-title":"Wildl. Res."},{"issue":"6","key":"2025102819543276400_R28","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1095\/BIOLREPROD.107.059915","article-title":"Chronic treatment of male tammar wallabies with deslorelin implants during pouch life: effects on development, puberty, and reproduction in adulthood.","volume":"76","author":"Herbert","year":"2007","journal-title":"Biol. Reprod."},{"key":"2025102819543276400_R29"},{"issue":"6","key":"2025102819543276400_R30","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1071\/RD12087","article-title":"Chronic treatment of female tammar wallabies with deslorelin implants during pouch life: effects on reproductive maturation.","volume":"25","author":"Herbert","year":"2013","journal-title":"Reprod. Fertil. Dev."},{"issue":"2","key":"2025102819543276400_R31","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/J.YGCEN.2009.06.021","article-title":"Fecal endocrine profiles and ejaculate traits in black-footed cats (Felis nigripes) and sand cats (Felis margarita).","volume":"165","author":"Herrick","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"issue":"2","key":"2025102819543276400_R32","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/J.1469-7998.2008.00419.X","article-title":"Pouch appearance is a reliable indicator of the reproductive status in the Tasmanian devil and the spotted-tailed quoll.","volume":"275","author":"Hesterman","year":"2008","journal-title":"J. Zool."},{"issue":"6","key":"2025102819543276400_R33","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/S10592-015-0754-9","article-title":"Influence of genetic provenance and birth origin on productivity of the Tasmanian devil insurance population.","volume":"16","author":"Hogg","year":"2015","journal-title":"Conserv. Genet."},{"issue":"1","key":"2025102819543276400_R34","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/CONL.12221","article-title":"\u201cDevil tools & tech\u201d: a synergy of conservation research and management practice.","volume":"10","author":"Hogg","year":"2017","journal-title":"Conserv. Lett."},{"issue":"1","key":"2025102819543276400_R35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/IZY.12144","article-title":"Metapopulation management of an endangered species with limited genetic diversity in the presence of disease: the Tasmanian devil Sarcophilus harrisii.","volume":"51","author":"Hogg","year":"2017","journal-title":"Int. Zoo Yearb."},{"issue":"2","key":"2025102819543276400_R36","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1638\/2015-0191.1","article-title":"Hematological and serum biochemical values in anesthetized captive Tasmanian devils (Sarcophilus harrisii).","volume":"47","author":"Hope","year":"2016","journal-title":"J. Zoo Wildl. Med."},{"key":"2025102819543276400_R37"},{"issue":"3","key":"2025102819543276400_R38","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/S10393-007-0120-6","article-title":"Conservation management of Tasmanian devils in the context of an emerging, extinction-threatening disease: devil facial tumor disease.","volume":"4","author":"Jones","year":"2007","journal-title":"EcoHealth"},{"issue":"29","key":"2025102819543276400_R39","doi-asserted-by":"publisher","first-page":"10023","DOI":"10.1073\/PNAS.0711236105","article-title":"Life-history change in disease-ravaged Tasmanian devil populations.","volume":"105","author":"Jones","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"2025102819543276400_R40","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1071\/RD03039","article-title":"Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue deslorelin for reversible long-term contraception in male dogs.","volume":"15","author":"Junaidi","year":"2003","journal-title":"Reprod. Fertil. Dev."},{"issue":"5","key":"2025102819543276400_R41","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/J.1439-0531.2008.01060.X","article-title":"Dose-response studies for pituitary and testicular function in male dogs treated with the GnRH superagonist, deslorelin.","volume":"44","author":"Junaidi","year":"2009","journal-title":"Reprod. Domest. Anim."},{"issue":"5","key":"2025102819543276400_R42","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/J.THERIOGENOLOGY.2010.03.026","article-title":"Effects of long-term treatment with the GnrH agonist deslorelin (Suprelorin\u00ae) on sexual function in boars.","volume":"74","author":"Kauffold","year":"2010","journal-title":"Theriogenology"},{"issue":"7","key":"2025102819543276400_R43","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1071\/RD12022","article-title":"Development and evaluation of electroejaculation techniques in the Tasmanian devil (Sarcophilus harrisii).","volume":"24","author":"Keeley","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"issue":"2","key":"2025102819543276400_R44","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/J.YGCEN.2012.01.011","article-title":"The reproductive cycle of the Tasmanian devil (Sarcophilus harrisii) and factors associated with reproductive success in captivity.","volume":"176","author":"Keeley","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"issue":"3","key":"2025102819543276400_R45","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/1365-2664.13088","article-title":"Density trends and demographic signals uncover the long-term impact of transmissible cancer in Tasmanian devils.","volume":"55","author":"Lazenby","year":"2018","journal-title":"J. Appl. Ecol."},{"issue":"1","key":"2025102819543276400_R46","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1530\/JRF.0.0800257","article-title":"Long-term stimulatory effects of a continuous infusion of LHRH agonist on testicular function in male red deer (Cervus elaphus).","volume":"80","author":"Lincoln","year":"1987","journal-title":"J. Reprod. Fertil."},{"issue":"2","key":"2025102819543276400_R47","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1677\/JOE.0.1250233","article-title":"Pituitary-testicular function is suppressed by an LHRH antagonist but not by an LHRH agonist in the marmoset monkey.","volume":"125","author":"Lunn","year":"1990","journal-title":"J. Endocrinol."},{"issue":"2","key":"2025102819543276400_R48","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1677\/JOE.0.1320217","article-title":"Influence of the gonad on the degree of suppression induced by an LHRH agonist implant in the marmoset monkey.","volume":"132","author":"Lunn","year":"1992","journal-title":"J. Endocrinol."},{"key":"2025102819543276400_R49"},{"issue":"1","key":"2025102819543276400_R50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1071\/AM08112","article-title":"The measurement of luteinising hormone in the western grey kangaroo (Macropus fuliginosus ocydromus) and the black-flanked rock wallaby (Petrogale lateralis lateralis).","volume":"31","author":"Matson","year":"2009","journal-title":"Aust. Mammal."},{"issue":"3","key":"2025102819543276400_R51","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0739-7240(87)90011-7","article-title":"Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian species.","volume":"4","author":"Matteri","year":"1987","journal-title":"Domest. Anim. Endocrinol."},{"key":"2025102819543276400_R52","doi-asserted-by":"crossref","unstructured":"Mayberry, C. J. (2011). Management of isolated populations of western grey kangaroos (Macropus fuliginosus ocydromus) through fertility control, in south-western Australia. Ph.D. Thesis, University of Western Australia, Perth.","DOI":"10.1071\/AM09029"},{"issue":"3","key":"2025102819543276400_R53","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/S10393-007-0118-0","article-title":"Distribution and impacts of Tasmanian devil facial tumor disease.","volume":"4","author":"McCallum","year":"2007","journal-title":"EcoHealth"},{"issue":"1","key":"2025102819543276400_R54","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2527\/JAS1986.621199X","article-title":"Elevation of serum testosterone during chronic LHRH agonist treatment in the bull.","volume":"62","author":"Melson","year":"1986","journal-title":"J. Anim. Sci."},{"issue":"3","key":"2025102819543276400_R55","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/J.THERIOGENOLOGY.2011.09.012","article-title":"Reproductive seasonality and the effect of the GnRH agonist deslorelin as a contraceptive in captive male black flying-foxes (Pteropus alecto).","volume":"77","author":"Melville","year":"2012","journal-title":"Theriogenology"},{"issue":"4","key":"2025102819543276400_R56","doi-asserted-by":"publisher","first-page":"941","DOI":"10.2307\/3803042","article-title":"Porcine zona pellucida immunocontraception: long-term health effects on white-tailed deer.","volume":"65","author":"Miller","year":"2001","journal-title":"J. Wildl. Manage."},{"issue":"10","key":"2025102819543276400_R57","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/J.1471-0528.1972.TB12182.X","article-title":"Variation in LH and FSH response to LH-releasing hormone during the menstrual cycle.","volume":"79","author":"Nillius","year":"1972","journal-title":"J Obstet Gynaecol Br Commonw"},{"issue":"Suppl 1","key":"2025102819543276400_R58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1472-6483(11)60210-1","article-title":"Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action.","volume":"5","author":"Ortmann","year":"2002","journal-title":"Reproductive Biomedicine Online"},{"issue":"4","key":"2025102819543276400_R59","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/VCP.12304","article-title":"Hematologic and serum biochemical reference intervals for wild Tasmanian devils (Sarcophilus harrisii).","volume":"44","author":"Peck","year":"2015","journal-title":"Vet. Clin. Pathol."},{"issue":"1\u20132","key":"2025102819543276400_R60","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/J.ANIREPROSCI.2009.03.005","article-title":"Oestrus in the Julia Creek dunnart (Sminthopsis douglasi) is associated with wheel running behaviour but not necessarily changes in body weight, food consumption or pouch morphology.","volume":"117","author":"Pollock","year":"2010","journal-title":"Anim. Reprod. Sci."},{"issue":"3","key":"2025102819543276400_R61","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0739-7240(93)90022-4","article-title":"Effects of continuous administration of gonadotropin-releasing hormone (GnRH) or a potent GnRH analogue on blood luteinizing hormone and testosterone concentrations in prepubertal bulls.","volume":"10","author":"Ronayne","year":"1993","journal-title":"Domest. Anim. Endocrinol."},{"issue":"5","key":"2025102819543276400_R62","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1046\/J.1365-2265.1996.730551.X","article-title":"The GnRH challenge test: a quantitative measure of pituitary desensitization during GnRH agonist administration.","volume":"44","author":"Scheele","year":"1996","journal-title":"Clin. Endocrinol."},{"issue":"7","key":"2025102819543276400_R63","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/J.1365-2826.2006.01440.X","article-title":"Testosterone and aggression: Berthold, birds and beyond.","volume":"18","author":"Soma","year":"2006","journal-title":"J. Neuroendocrinol."},{"issue":"3","key":"2025102819543276400_R64","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/JES.0B013E31817BE928","article-title":"Sex hormone effects on body fluid regulation.","volume":"36","author":"Stachenfeld","year":"2008","journal-title":"Exerc. Sport Sci. Rev."},{"issue":"5","key":"2025102819543276400_R65","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1177\/1933719113518992","article-title":"Hormonal changes during menopause and the impact on fluid regulation.","volume":"21","author":"Stachenfeld","year":"2014","journal-title":"Reprod. Sci."},{"issue":"9252","key":"2025102819543276400_R66","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(00)03622-9","article-title":"Uterine fibroids.","volume":"357","author":"Stewart","year":"2001","journal-title":"Lancet"},{"issue":"1","key":"2025102819543276400_R67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0029-7844(95)00102-W","article-title":"GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: a randomized controlled trial.","volume":"86","author":"Stovall","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"2025102819543276400_R68","first-page":"255","article-title":"Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs.","volume":"57","author":"Trigg","year":"2001","journal-title":"J. Reprod. Fertil. Suppl."},{"issue":"4","key":"2025102819543276400_R69","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/ZOO.10052","article-title":"Reproductive endocrine patterns in captive female and male red wolves (Canis rufus) assessed by fecal and serum hormone analysis.","volume":"21","author":"Walker","year":"2002","journal-title":"Zoo Biol."},{"issue":"4","key":"2025102819543276400_R70","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.3390\/ANI5040414","article-title":"Finding the balance: fertility control for the management of fragmented populations of a threatened rock-wallaby species.","volume":"5","author":"Willers","year":"2015","journal-title":"Animals (Basel)"},{"issue":"5","key":"2025102819543276400_R71","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1071\/WR13050","article-title":"Deslorelin implants in free-ranging female eastern grey kangaroos (Macropus giganteus): mechanism of action and contraceptive efficacy.","volume":"40","author":"Wilson","year":"2013","journal-title":"Wildl. Res."},{"issue":"6","key":"2025102819543276400_R72","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1210\/JCEM-35-6-931","article-title":"Variation of pituitary responsiveness to synthetic LRF during different phases of the menstrual cycle.","volume":"35","author":"Yen","year":"1972","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/31\/9\/1473\/313361\/rd18407.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/31\/9\/1473\/313361\/rd18407.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:54:40Z","timestamp":1761695680000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/31\/9\/1473\/50280\/Contraceptive-efficacy-and-dose-response-effects"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,3]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8,12]]}},"URL":"https:\/\/doi.org\/10.1071\/rd18407","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,3]]}}}