{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:00:20Z","timestamp":1761717620810,"version":"build-2065373602"},"reference-count":38,"publisher":"CSIRO Publishing","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2031,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,22]]},"abstract":"<jats:p>Here we describe the case of a pig with intersex traits including ambiguous external genitalia, sex chromosome abnormalities and a late-onset vanishing testis-like syndrome. It was identified shortly after birth by presenting a predominantly female phenotype with two large scrotal masses resembling testes. The karyotype is 38,XX (53%)\/38,XY (47%). Sex steroid levels were undetectable at 1 and 7 months old, whereas circulating cortisol levels were typical. DNA studies excluded gene alterations in sex-determining region Y (SRY), dosage-sensitive sex reversal-congenital adrenal hypoplasia critical region on the X chromosome protein 1 (DAX1), SRY-related high mobility group-box gene 9 (SOX9), nuclear receptor subfamily 5, group a, member 1 (NR5A1), nuclear receptor subfamily 3, group c, member 4 (NR3C4) and steroid 5-alpha-reductase 2 (SRD5A2). At 8 months of age the XX\/XY pig evinced delayed growth; however, the most striking phenotypic change was that the testes-like structures completely vanished in a 2\u20133-week period. The internal genitalia were found to consist of a portion of a vagina and urethra. No fallopian tubes, uterus or remnants of Wolffian derivatives were observed. More importantly, no testes, ovaries, ovotestis or gonadal streaks could be identified. The XX\/XY sex chromosome dosage and\/or overexpression of the DAX1 gene on the X chromosome in the presence of a wild-type SRY gene may have caused this predominantly female phenotype. This specimen represents an atypical case of 38,XX\/38,XY chimeric, ovotesticular disorder of sex development associated with agonadism.<\/jats:p>","DOI":"10.1071\/rd18514","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T23:32:52Z","timestamp":1572823972000},"page":"284-291","source":"Crossref","is-referenced-by-count":3,"title":["Late-onset vanishing testis-like syndrome in a 38,XX\/38,XY agonadic pig (Sus scrofa)"],"prefix":"10.1071","volume":"32","author":[{"given":"Felipe","family":"Vilchis","sequence":"first","affiliation":[{"name":"ADepartment of Reproductive Biology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga #15, Tlalpan, C.P. 14080, M\u00e9xico City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizette","family":"Mares","sequence":"additional","affiliation":[{"name":"ADepartment of Reproductive Biology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga #15, Tlalpan, C.P. 14080, M\u00e9xico City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"ADepartment of Reproductive Biology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga #15, Tlalpan, C.P. 14080, M\u00e9xico City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcadio","family":"Paredes","sequence":"additional","affiliation":[{"name":"ADepartment of Reproductive Biology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga #15, Tlalpan, C.P. 14080, M\u00e9xico City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-3262","authenticated-orcid":true,"given":"Luis","family":"Ramos","sequence":"additional","affiliation":[{"name":"ADepartment of Reproductive Biology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga #15, Tlalpan, C.P. 14080, M\u00e9xico City, M\u00e9xico."},{"name":"BCorresponding author. 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