{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:39:31Z","timestamp":1790185171764,"version":"4.1.0"},"reference-count":43,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":1932,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:p>Di-(2-ethylhexyl) phthalate (DEHP) is ubiquitous in the environment and has been proposed to lead to reproductive disruption. In this study, we systematically investigated the effects of different doses of DEHP exposure on female hypothalamic\u2013pituitary\u2013gonadal axis development. Female Sprague\u2013Dawley rats were gavaged with vehicle (corn oil) or DEHP (5 or 500\u00a0mg\u00a0kg\u20131 day\u20131) during postnatal Days (PNDs) 22\u201328 or PNDs 22\u201370. Results demonstrated that the low and high doses of DEHP exerted opposite effects on puberty onset, circulating luteinising hormone, serum oestradiol and progesterone levels, with the low dose (5\u00a0mg\u00a0kg\u20131) promoting and the high dose (500\u00a0mg\u00a0kg\u20131) inhibiting these parameters. Significant dose-related differences were also found in the D500 group with longer oestrous cycle duration, lower ovarian\/bodyweight ratio, fewer corpus lutea and more abnormal ovarian stromal tissue in comparison with the oil or D5 groups. Molecular data showed that the hypothalamic Kiss1 mRNA expression in the anteroventral periventricular but not in the arcuate nucleus significantly decreased in the D500 rats and increased in the D5 rats relative to the rats in the oil group. These findings suggested that the kisspeptin system is a potential target for DEHP to disrupt reproductive development and function.<\/jats:p>","DOI":"10.1071\/rd19024","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T17:27:38Z","timestamp":1581355658000},"page":"610-618","source":"Crossref","is-referenced-by-count":23,"title":["Opposite effects of high- and low-dose di-(2-ethylhexyl) phthalate (DEHP) exposure on puberty onset, oestrous cycle regularity and hypothalamic kisspeptin expression in female rats"],"prefix":"10.1071","volume":"32","author":[{"given":"Zhen","family":"Yu","sequence":"first","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyong","family":"Han","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmei","family":"Lu","sequence":"additional","affiliation":[{"name":"BDepartment of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"CShengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchun","family":"Cai","sequence":"additional","affiliation":[{"name":"BDepartment of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishuang","family":"Li","sequence":"additional","affiliation":[{"name":"CShengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Lin","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Lin","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-2384","authenticated-orcid":true,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"AFujian Key Laboratory of Medical Measurement, Fujian Academy of Medical Sciences, Fuzhou 350001, China."},{"name":"BDepartment of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China."},{"name":"DCorresponding authors: Emails:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Wen","sequence":"additional","affiliation":[{"name":"BDepartment of Endocrinology, Fujian Provincial Hospital, Fuzhou 350001, China."},{"name":"DCorresponding authors: Emails:"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"2025102820072871200_R1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/TOXSCI\/KFY072","article-title":"Effects of in utero and lactational exposure to new generation green plasticizers on adult male rats: a comparative study with di(2-ethylhexyl) phthalate.","volume":"164","author":"Albert","year":"2018","journal-title":"Toxicol. 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