{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:19:47Z","timestamp":1790263187860,"version":"4.1.0"},"reference-count":67,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":1946,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:p>The objective of this study was to evaluate the differences in the uterine flush fluid proteome between healthy mares and mares with endometritis or fibrotic endometrial degeneration (FED). Uterine flush fluid samples were collected from healthy mares (n\u00a0=\u00a08; oestrus n\u00a0=\u00a05 and dioestrus n\u00a0=\u00a03) and mares with endometritis (n\u00a0=\u00a023; oestrus n\u00a0=\u00a014 and dioestrus n\u00a0=\u00a09) or FED (n\u00a0=\u00a07; oestrus n\u00a0=\u00a06 and dioestrus n\u00a0=\u00a01). Proteomic analysis was performed using label-free liquid chromatography\u2013tandem mass spectrometry. Of 216 proteins identified during oestrus, 127 were common to all three groups, one protein was exclusively detected in healthy mares, 47 proteins were exclusively detected in mares with endometritis and four proteins were exclusively detected in mares with FED. Of 188 proteins identified during dioestrus, 113 proteins were common between healthy mares and mares with endometritis, eight proteins were exclusively detected in healthy mares and 67 proteins were exclusively detected in mares with endometritis. Quantitative analysis revealed a subset of proteins differing in abundance between the three groups during oestrus and between healthy mares and mares with endometritis during dioestrus. These results provide a springboard for evaluation of specific proteins as biomarkers of uterine health and disease and for investigation of their roles in the establishment and maintenance of pregnancy.<\/jats:p>","DOI":"10.1071\/rd19085","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T22:56:25Z","timestamp":1580165785000},"page":"572-581","source":"Crossref","is-referenced-by-count":21,"title":["Analysis of the uterine flush fluid proteome of healthy mares and mares with endometritis or fibrotic endometrial degeneration"],"prefix":"10.1071","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-3654","authenticated-orcid":true,"given":"Mariana","family":"Diel de Amorim","sequence":"first","affiliation":[{"name":"ADepartment of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G2W1, Canada."},{"name":"DPresent address: Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA."},{"name":"FCorresponding authors. Emails:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdous A.","family":"Khan","sequence":"additional","affiliation":[{"name":"ADepartment of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G2W1, Canada."},{"name":"BDepartment of Large Animal Medicine and Surgery, School of Veterinary Medicine, St. George\u2019s University, True Blue, St. George\u2019s, Grenada."},{"name":"EPresent address: Department of Large Animal Medicine and Surgery, School of Veterinary Medicine, St. George\u2019s University, True Blue, St. George\u2019s, Grenada."},{"name":"FCorresponding authors. Emails:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey S.","family":"Chenier","sequence":"additional","affiliation":[{"name":"ADepartment of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G2W1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Scholtz","sequence":"additional","affiliation":[{"name":"ADepartment of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G2W1, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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