{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:47:51Z","timestamp":1768553271458,"version":"3.49.0"},"reference-count":63,"publisher":"CSIRO Publishing","issue":"10","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":2161,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,6]]},"abstract":"<jats:p>As an important gram-negative bacterial outer membrane component, lipopolysaccharide (LPS) plays an important role in bacterial-induced endometritis in sows. However, how LPS induces endometritis is unclear. We stimulated sow endometrial epithelial cells (EECs) with LPS and detected cell viability and tumour necrosis factor-a (TNF-a) and interleukin-1 (IL-1) secretion. LPS affected EEC viability and TNF-a and IL-1 secretion in a dose-dependent manner. LPS induced differential expression in 10 of 393 miRNAs in the EECs (downregulated, nine; upregulated, one). MicroRNA (miRNA) high-throughput sequencing of the LPS-induced EECs plus bioinformatics analysis and the dual-luciferase reporter system revealed a novel miRNA target gene: mitogen-activated protein kinase kinase kinase 14 (MAP3K14). Ssc-novel-miR-106-5p mimic, inhibitor and the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (I?Ba) phosphorylation inhibitor Bay11\u20137085 were used to detect EEC nuclear factor-?B phosphorylation levels (p-NF-?B) and TNF-a and IL-1 secretion. MiR-106-5p mimic downregulated MAP3K14 mRNA and protein expression levels, inhibited p-NF-?B levels and decreased IL-1 and TNF-a secretion, whereas miR-106-5p inhibitor had the opposite effect. Bay11\u20137085 inhibited p-NF-?B expression and TNF-a and IL-1 secretion. These results suggest that LPS downregulates ssc-novel-miR-106-5p expression in sow EECs to increase MAP3K14 expression, which increases p-NF-?B to promote IL-1 and TNF-a secretion.<\/jats:p>","DOI":"10.1071\/rd19097","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T01:35:58Z","timestamp":1561599358000},"page":"1616-1627","source":"Crossref","is-referenced-by-count":5,"title":["Ssc-novel-miR-106-5p reduces lipopolysaccharide-induced inflammatory response in porcine endometrial epithelial cells by inhibiting the expression of the target gene mitogen-activated protein kinase kinase kinase 14 (MAP3K14)"],"prefix":"10.1071","volume":"31","author":[{"given":"Yu","family":"Lian","sequence":"first","affiliation":[{"name":"AChongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Beibei, Chongqing 400716, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"AChongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Beibei, Chongqing 400716, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"AChongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Beibei, Chongqing 400716, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Nan","family":"Huo","sequence":"additional","affiliation":[{"name":"AChongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Beibei, Chongqing 400716, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"BCollege of Resource and Environment, Southwest University, Beibei, Chongqing 400716, P. R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-1540","authenticated-orcid":true,"given":"Xian-Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"AChongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Beibei, Chongqing 400716, P. R. China."},{"name":"CCorresponding author. Email: xianzhong_wang@aliyun.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"issue":"1","key":"2025102819560746400_R1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/J.JRI.2007.03.014","article-title":"Toll-like receptors in female reproductive tract and their menstrual cycle dependent expression.","volume":"77","author":"Aflatoonian","year":"2008","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"2025102819560746400_R2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1095\/BIOLREPROD.113.115972","article-title":"Differential endometrial cell sensitivity to a cholesterol-dependent cytolysin links Trueperella pyogenes to uterine disease in cattle.","volume":"90","author":"Amos","year":"2014","journal-title":"Biol. Reprod."},{"issue":"15","key":"2025102819560746400_R3","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-?B \u2013 a pivotal transcription factor in chronic inflammatory diseases.","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"2025102819560746400_R4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1385\/CT:6:2:111","article-title":"The NF-?B regulatory network.","volume":"6","author":"Brasier","year":"2006","journal-title":"Cardiovasc. Toxicol."},{"issue":"3\u20134","key":"2025102819560746400_R5","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/J.VETIMM.2006.04.002","article-title":"In vitro down regulation of proinflammatory cytokines induced by LPS tolerance in pig CD14+ cells.","volume":"112","author":"Cagiola","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"7","key":"2025102819560746400_R6","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/SJ.LEU.2402945","article-title":"Signal transduction mediated by the Ras\/Raf\/MEK\/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"issue":"3","key":"2025102819560746400_R7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/J.REPBIO.2017.05.006","article-title":"Bovine herpes virus type 4 alters TNF-a and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells.","volume":"17","author":"Chanrot","year":"2017","journal-title":"Reprod. Biol."},{"issue":"5654","key":"2025102819560746400_R8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/SCIENCE.1091903","article-title":"MicroRNAs modulate hematopoietic lineage differentiation.","volume":"303","author":"Chen","year":"2004","journal-title":"Science"},{"issue":"10","key":"2025102819560746400_R9","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1007\/S13238-017-0480-9","article-title":"TDP-43 regulates cancer-associated microRNAs.","volume":"9","author":"Chen","year":"2018","journal-title":"Protein Cell"},{"issue":"1","key":"2025102819560746400_R10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1677\/JOE.1.05910","article-title":"The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes.","volume":"184","author":"Cheng","year":"2005","journal-title":"J. Endocrinol."},{"issue":"14","key":"2025102819560746400_R11","doi-asserted-by":"publisher","first-page":"8948","DOI":"10.1128\/JVI.79.14.8948-8959.2005","article-title":"Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14\/NIK expression and nuclear complex formation with NF-kappaB2.","volume":"79","author":"Choudhary","year":"2005","journal-title":"J. Virol."},{"issue":"12","key":"2025102819560746400_R12","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1111\/JPHP.12628","article-title":"Propolis modulates miRNAs involved in TLR-4 pathway, NF-?B activation, cytokine production and in the bactericidal activity of human dendritic cells.","volume":"68","author":"Conti","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"issue":"4","key":"2025102819560746400_R13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/J.PHRS.2009.05.001","article-title":"Effects of genetic and pharmacological inhibition of TNF-alpha in the regulation of inflammation in macrophages.","volume":"60","author":"Crisafulli","year":"2009","journal-title":"Pharmacol. Res."},{"issue":"9","key":"2025102819560746400_R14","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1084\/JEM.20050640","article-title":"Blocking IL-1 in systemic inflammation.","volume":"201","author":"Dinarello","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025102819560746400_R15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/J.INTIMP.2018.01.021","article-title":"Cortisol inhibits NF-?B and MAPK pathways in LPS activated bovine endometrial epithelial cells.","volume":"56","author":"Dong","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"24","key":"2025102819560746400_R16","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1158\/0008-5472.CAN-12-3229","article-title":"TLRs as miRNA receptors.","volume":"72","author":"Fabbri","year":"2012","journal-title":"Cancer Res."},{"issue":"4","key":"2025102819560746400_R17","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/VMS3.115","article-title":"Rifaximin anti-inflammatory activity on bovine endometrium primary cell cultures: a preliminary study.","volume":"4","author":"Flammini","year":"2018","journal-title":"Vet. Med. Sci."},{"issue":"1\u20133","key":"2025102819560746400_R18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/J.1432-0436.1979.TB01030.X","article-title":"Identification and characterization of epithelial cells in mammalian tissues by immunofluorescence microscopy using antibodies to prekeratin.","volume":"15","author":"Franke","year":"1979","journal-title":"Differentiation"},{"issue":"4","key":"2025102819560746400_R19","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0022-2836(81)90460-5","article-title":"Diversity of cytokeratins: differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues.","volume":"153","author":"Franke","year":"1981","journal-title":"J. Mol. Biol."},{"issue":"1\u20132","key":"2025102819560746400_R20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0165-2427(03)00137-5","article-title":"Endometrial IL-1beta, IL-6 and TNF-alpha, mRNA expression in mares resistant or susceptible to post-breeding endometritis. Effects of estrous cycle, artificial insemination and immunomodulation.","volume":"96","author":"Fumuso","year":"2003","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"9","key":"2025102819560746400_R21","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/J.THERIOGENOLOGY.2005.04.022","article-title":"Prevalence of endometritis and its effects on reproductive performance of dairy cows.","volume":"64","author":"Gilbert","year":"2005","journal-title":"Theriogenology"},{"issue":"6","key":"2025102819560746400_R22","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/S12192-018-0925-Y","article-title":"ERK1\/2 regulates heat stress-induced lactate production via enhancing the expression of HSP70 in immature boar Sertoli cells.","volume":"23","author":"Guan","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"2025102819560746400_R23","doi-asserted-by":"publisher","first-page":"7060","DOI":"10.1038\/SREP07060","article-title":"Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1.","volume":"4","author":"Healy","year":"2014","journal-title":"Sci. Rep."},{"issue":"1","key":"2025102819560746400_R24","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1210\/EN.2005-1113","article-title":"Expression and function of Toll-like receptor 4 in bovine endometrium.","volume":"147","author":"Herath","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"2025102819560746400_R25","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/S10753-016-0492-2","article-title":"Expression of miRNA-155, miRNA-223, miRNA-31, miRNA-21, miRNA-125b, and miRNA-146a in the inflammatory pathway of hidradenitis suppurativa.","volume":"40","author":"Hessam","year":"2017","journal-title":"Inflammation"},{"issue":"5596","key":"2025102819560746400_R26","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1126\/SCIENCE.1071914","article-title":"The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation.","volume":"298","author":"Hoffmann","year":"2002","journal-title":"Science"},{"issue":"1","key":"2025102819560746400_R27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1021\/ACS.JAFC.5B05195","article-title":"Chitosan oligosaccharide reduces intestinal inflammation that involves calcium-sensing receptor (CaSR) activation in lipopolysaccharide (LPS)-challenged piglets.","volume":"64","author":"Huang","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"2025102819560746400_R28","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/J.THERIOGENOLOGY.2015.01.021","article-title":"The influence of leukotrienes C4 and D4 on the contractility of an inflamed porcine uterus.","volume":"83","author":"Jana","year":"2015","journal-title":"Theriogenology"},{"issue":"1","key":"2025102819560746400_R29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/NRD1279","article-title":"The IKK NF-kappa B system: a treasure trove for drug development.","volume":"3","author":"Karin","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"2025102819560746400_R30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/NI.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"7","key":"2025102819560746400_R31","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0129743","article-title":"Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation.","volume":"10","author":"Lan","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"2025102819560746400_R32","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3390\/IJMS17040499","article-title":"Comparative small RNA analysis of pollen development in autotetraploid and diploid rice.","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"2025102819560746400_R33","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1002\/PTR.4810","article-title":"Methylalpinumisoflavone inhibits lipopolysaccharide-induced inflammation in microglial cells by the NF-kappaB and MAPK signaling pathway.","volume":"26","author":"Lim","year":"2012","journal-title":"Phytother. Res."},{"issue":"1","key":"2025102819560746400_R34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1530\/REP-12-0253","article-title":"Polarised bovine endometrial epithelial cells vectorially secrete prostaglandins and chemotactic factors under physiological and pathological conditions.","volume":"145","author":"MacKintosh","year":"2013","journal-title":"Reproduction"},{"issue":"11","key":"2025102819560746400_R35","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/3276","article-title":"Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand.","volume":"4","author":"Miwa","year":"1998","journal-title":"Nat. Med."},{"issue":"1","key":"2025102819560746400_R36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"issue":"5","key":"2025102819560746400_R37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/CMI.2011.26","article-title":"MicroRNA in TLR signaling and endotoxin tolerance.","volume":"8","author":"Nahid","year":"2011","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"2025102819560746400_R38","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/J.YMETH.2005.11.009","article-title":"The repetitive use of samples to measure multiple cytokines: the sequential ELISA.","volume":"38","author":"Osuchowski","year":"2006","journal-title":"Methods"},{"issue":"11","key":"2025102819560746400_R39","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1002\/IJC.23173","article-title":"Inflammation and cancer: an ancient link with novel potentials.","volume":"121","author":"Perwez Hussain","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"34","key":"2025102819560746400_R40","doi-asserted-by":"publisher","first-page":"21096","DOI":"10.1074\/JBC.272.34.21096","article-title":"Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo.","volume":"272","author":"Pierce","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"8","key":"2025102819560746400_R41","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/J.FEBSLET.2012.03.011","article-title":"microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-?B1 in murine macrophages.","volume":"586","author":"Qi","year":"2012","journal-title":"FEBS Lett."},{"issue":"10","key":"2025102819560746400_R42","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1242\/BIO.025866","article-title":"An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix.","volume":"6","author":"Qureshi","year":"2017","journal-title":"Biol. Open"},{"issue":"2","key":"2025102819560746400_R43","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1096\/FJ.10-169599","article-title":"MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits.","volume":"25","author":"Recchiuti","year":"2011","journal-title":"FASEB J."},{"issue":"18","key":"2025102819560746400_R44","doi-asserted-by":"publisher","first-page":"6940","DOI":"10.1073\/PNAS.86.18.6940","article-title":"Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine\/threonine protein kinase.","volume":"86","author":"Rossomando","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"2025102819560746400_R45","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/S12864-016-2513-9","article-title":"Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile.","volume":"17","author":"Salilew-Wondim","year":"2016","journal-title":"BMC Genomics"},{"issue":"2","key":"2025102819560746400_R46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1089\/JMF.2005.8.149","article-title":"Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthritic sow chondrocytes.","volume":"8","author":"Shen","year":"2005","journal-title":"J. Med. Food"},{"issue":"5","key":"2025102819560746400_R47","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0154934","article-title":"Type of inflammation differentially affects expression of interleukin 1\u00df and 6, tumor necrosis factor-a and Toll-like receptors in subclinical endometritis in mares.","volume":"11","author":"Siemieniuch","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"2025102819560746400_R48","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/J.AUTREV.2013.07.003","article-title":"The role of miRNA in inflammation and autoimmunity.","volume":"12","author":"Singh","year":"2013","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"2025102819560746400_R49","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1158\/2159-8290.CD-13-1007","article-title":"The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFa.","volume":"4","author":"Smith","year":"2014","journal-title":"Cancer Discov."},{"issue":"12","key":"2025102819560746400_R50","doi-asserted-by":"publisher","DOI":"10.1126\/SCIIMMUNOL.AAL3062","article-title":"Citrullination of NF-?B p65 promotes its nuclear localization and TLR-induced expression of IL-1\u00df and TNFa.","volume":"2","author":"Sun","year":"2017","journal-title":"Sci. Immunol."},{"issue":"1","key":"2025102819560746400_R51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.21836\/PEM20100113","article-title":"Establishment of a new method for isolation and culture of equine endometrial epithelial and stromal cells.","volume":"26","author":"Theu\u00df","year":"2010","journal-title":"Pferdeheilkunde"},{"issue":"8","key":"2025102819560746400_R52","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/S10571-017-0468-2","article-title":"Piracetam attenuates LPS-induced neuro inflammation and cognitive impairment in rats.","volume":"37","author":"Tripathi","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"2025102819560746400_R53","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/EVJ.13004","article-title":"Limitations of a chromogenic agar plate for the identifying bacteria isolated from equine endometritis samples.","volume":"51","author":"Vera","year":"2019","journal-title":"Equine Vet. J."},{"issue":"1","key":"2025102819560746400_R54","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/S10753-014-0003-2","article-title":"Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model.","volume":"38","author":"Wei","year":"2015","journal-title":"Inflammation"},{"issue":"1","key":"2025102819560746400_R55","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/JPN.12686","article-title":"Involvement of PKA signalling in anti-inflammatory effects of chitosan oligosaccharides in IPEC-J2 porcine epithelial cells.","volume":"102","author":"Yang","year":"2018","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl.)"},{"issue":"9","key":"2025102819560746400_R56","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1002\/IJC.29268","article-title":"A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide.","volume":"136","author":"Ye","year":"2015","journal-title":"Int. J. Cancer"},{"key":"2025102819560746400_R57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/J.THERIOGENOLOGY.2018.07.039","article-title":"AMP-activated protein kinase negatively regulates heat treatment-induced lactate secretion in cultured boar Sertoli cells.","volume":"121","author":"Yu","year":"2018","journal-title":"Theriogenology"},{"key":"2025102819560746400_R58","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1186\/GB-2010-11-2-R14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias.","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"issue":"5740","key":"2025102819560746400_R59","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1126\/SCIENCE.1111444","article-title":"The big world of small RNAs.","volume":"309","author":"Zamore","year":"2005","journal-title":"Science"},{"issue":"1","key":"2025102819560746400_R60","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8597208","article-title":"Piperine plays an anti-inflammatory role in Staphylococcus aureus endometritis by inhibiting activation of NF-?B and MAPK pathways in mice.","volume":"2016","author":"Zhai","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"3","key":"2025102819560746400_R61","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/EXD.13490","article-title":"A pathway-based association analysis identified FMNL1\u2013MAP3K14 as susceptibility genes for leprosy.","volume":"27","author":"Zhang","year":"2018","journal-title":"Exp. Dermatol."},{"key":"2025102819560746400_R62","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.3389\/FIMMU.2018.01916","article-title":"The potential therapeutic role of miR-223 in bovine endometritis by targeting the NLRP3 inflammasome.","volume":"9","author":"Zhao","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"2025102819560746400_R63","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/S10753-018-0874-8","article-title":"Oridonin ameliorates lipopolysaccharide-induced endometritis in mice via inhibition of the TLR-4\/NF-?B pathway.","volume":"42","author":"Zhou","year":"2019","journal-title":"Inflammation"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/31\/10\/1616\/313677\/rd19097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/31\/10\/1616\/313677\/rd19097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:56:11Z","timestamp":1761695771000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/31\/10\/1616\/50315\/Ssc-novel-miR-106-5p-reduces-lipopolysaccharide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,27]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,9,6]]}},"URL":"https:\/\/doi.org\/10.1071\/rd19097","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,27]]}}}