{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:42:15Z","timestamp":1774312935026,"version":"3.50.1"},"reference-count":57,"publisher":"CSIRO Publishing","issue":"14","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":1698,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,16]]},"abstract":"<jats:p>The porcine myometrium possesses steroidogenic activity. LH and FSH are hypothesised to regulate the myometrial production of androstenedione (A4), testosterone (T), oestrone (E1) and 17\u03b2-oestradiol (E2). In this study, we used myometrium collected from cycling (n = 15) and pregnant (n = 15) pigs on Days 10\u201311, 12\u201313 and 15\u201316 of the oestrous cycle or pregnancy to determine: (1) the abundance of LH and FSH receptor (LH\/choriogonadotrophin receptor (CGR) and FSHR) mRNA and protein; (2) activity of 17\u03b2-hydroxysteroid dehydrogenase 1 (17\u03b2HSD1); and (3) A4, T, E1 and E2 release in response to LH and FSH treatment, used at doses 10 or 100 ng mL\u22121 for 6 h. In results, the myometrium possesses LH\/CGR and FSHR with minor alterations in their expression in the course of the oestrous cycle or early pregnancy. 17\u03b2HSD1 activity was the highest on Days 12\u201313 of the oestrous cycle and the lowest on Days 15\u201316 of the oestrus cycle and pregnancy, when compared to the other studied days of the oestrous cycle or pregnancy. The LH and FSH treatment increased A4 release on Days 12\u201313 of the oestrous cycle, and E1 and E2 release on Days 15\u201316 of the oestrous cycle. Moreover, on Days 12\u201313 E2 release was increased in response to FSH treatment (100 ng mL\u22121) in cycling pigs and in response to LH (100 ng mL\u22121) in pregnant pigs. In conclusion, the myometrium of pregnant and non-pregnant pigs expresses LH\/CGR and FSHR and has 17\u03b2HSD1 activity. In addition, the amount of A4, E1, and E2 release from the myometrium is altered in response to LH and FSH, especially in cycling pigs. LH and FSH appear to be important regulators of myometrial oestrogen release in pigs mostly during luteolysis.<\/jats:p>","DOI":"10.1071\/rd20148","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T19:32:18Z","timestamp":1601580738000},"page":"1200-1211","source":"Crossref","is-referenced-by-count":14,"title":["Effects of LH and FSH on androgen and oestrogen release in the myometrium of pigs during the oestrous cycle and early pregnancy"],"prefix":"10.1071","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-0190","authenticated-orcid":true,"given":"Ewa M.","family":"Waszkiewicz","sequence":"first","affiliation":[{"name":"ADepartment of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718 Olsztyn, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-130X","authenticated-orcid":true,"given":"Agata","family":"Zmijewska","sequence":"additional","affiliation":[{"name":"ADepartment of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718 Olsztyn, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktoria","family":"Kozlowska","sequence":"additional","affiliation":[{"name":"ADepartment of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718 Olsztyn, Poland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-8207","authenticated-orcid":true,"given":"Anita","family":"Franczak","sequence":"additional","affiliation":[{"name":"ADepartment of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-718 Olsztyn, Poland."},{"name":"BCorresponding author. 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