{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:02:34Z","timestamp":1785762154725,"version":"3.56.0"},"reference-count":65,"publisher":"CSIRO Publishing","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":718,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["Group BIOFITER, A07_20R"],"award-info":[{"award-number":["Group BIOFITER, A07_20R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,11]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Melatonin influences female reproduction, but expression of the melatonin system has not been characterised in the ovine uterus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to determine whether synthesising enzymes (arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin-O-methyltransferase (ASMT)), melatonin receptors 1 and 2 (MT1 and MT2), and catabolising enzymes (myeloperoxidase (MPO) and indoleamine 2,3-dioxygenase 1 and 2 (IDO1 and 2)), are expressed in the ovine uterus, and if they are influenced by the oestrous cycle (Experiment 1) or by undernutrition (Experiment 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In Experiment 1, gene and protein expression was determined in sheep endometrium samples collected on days 0 (oestrus), 5, 10 and 14 of the oestrous cycle. In Experiment 2, we studied uterine samples from ewes fed either 1.5 or 0.5\u00a0times their maintenance requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>We have demonstrated the expression of AANAT and ASMT in the endometrium of sheep. AANAT and ASMT transcripts, and AANAT protein were more elevated at day 10, then decreased to day 14. A similar pattern was observed for MT2, IDO1, and MPO mRNA, which suggests that the endometrial melatonin system might be influenced by ovarian steroid hormones. Undernutrition increased AANAT mRNA expression, but seemed to decrease its protein expression, and increased MT2 and IDO2 transcripts, whereas ASMT expression was unaffected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The melatonin system is expressed in the ovine uterus and is affected by oestrous cycle and undernutrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>The results help explain the adverse effects of undernutrition on reproduction in sheep, and the success of exogenous melatonin treatments in improving reproductive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd22194","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T18:40:40Z","timestamp":1686249640000},"page":"563-574","source":"Crossref","is-referenced-by-count":8,"title":["The melatonin system is expressed in the ovine uterus: effect of the day of the oestrous cycle and undernutrition"],"prefix":"10.1071","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2907-0427","authenticated-orcid":true,"given":"C.","family":"Sosa","sequence":"first","affiliation":[{"name":"ADepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Universidad de Zaragoza, Facultad de Veterinaria, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Laurenzana","sequence":"additional","affiliation":[{"name":"ADepartamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Universidad de Zaragoza, Facultad de Veterinaria, Zaragoza, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"de Brun","sequence":"additional","affiliation":[{"name":"BLaboratorio de Endocrinolog\u00eda y Metabolismo Animal, Facultad de Veterinaria, UdelaR, Montevideo, Uruguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Meikle","sequence":"additional","affiliation":[{"name":"BLaboratorio de Endocrinolog\u00eda y Metabolismo Animal, Facultad de Veterinaria, UdelaR, Montevideo, Uruguay."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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