{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:16:56Z","timestamp":1765041416078,"version":"build-2065373602"},"reference-count":65,"publisher":"CSIRO Publishing","issue":"9","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":736,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"name":"National Institute for Medical Research Development (NIMAD)","award":["973377"],"award-info":[{"award-number":["973377"]}]},{"DOI":"10.13039\/501100005014","name":"Avicenna Research Institute","doi-asserted-by":"crossref","award":["96-037"],"award-info":[{"award-number":["96-037"]}],"id":[{"id":"10.13039\/501100005014","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,5]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Implantation of fertilised eggs and survival of a semi-allogenic embryo rely on the interactions between the cells and molecules preparing the uterus. We investigated the effect of regulatory T cell (Treg) therapy on the mechanism of local immune tolerance of mice prone to spontaneous abortion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Naive T cells were stimulated in vitro with 17\u00df-oestradiol (E2), progesterone (P4) and TGF-\u00df1 for 96\u00a0h to generate induced Tregs (iTreg). The iTregs were injected into DBA\/2-mated pregnant CBA\/J female mice (abortion prone model). On day 14 of pregnancy, mice were killed and decidual and placental tissues were collected for cellular composition analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Abortion prone mice (PBS treated) showed significantly lower survival rates (P\u00a0&amp;lt;\u00a00.0001), increased CD3+CD8+ (P\u00a0&amp;lt;\u00a00.05), lower IDO+ (P\u00a0&amp;lt;\u00a00.05) and increased natural killer cells (uNK) cell numbers (P\u00a0&amp;lt;\u00a00.001) in the uterus, as well increased NK cells in the placenta (P\u00a0&amp;lt;\u00a00.05) than in normal pregnant mice (CBA\/J\u00a0\u00d7\u00a0BALB\/c). Adoptive transfer of iTregs increased fetal survival in abortion-prone mice (P\u00a0&amp;lt;\u00a00.01) and histopathological evaluation revealed a significantly decreased number of uNK cells in the uterus of TGF-\u00df1-, E2- and P4-iTregs (P\u00a0&amp;lt;\u00a00.05, P\u00a0&amp;lt;\u00a00.0001 and P\u00a0&amp;lt;\u00a00.05, respectively) than in the PBS treated group. In the placenta, we found significantly lower numbers of uNK cells from TGF-\u00df1-, E2- and P4-iTregs than in the PBS treated group (P\u00a0&amp;lt;\u00a00.05, P\u00a0&amp;lt;\u00a00.05 and P\u00a0&amp;lt;\u00a00.01, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We propose that modulation of uterine NK cell activity through immunotherapy using Treg cells should be given more attention as an immunological strategy in the treatment of recurrent miscarriage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd22267","type":"journal-article","created":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T21:56:05Z","timestamp":1684706165000},"page":"504-517","source":"Crossref","is-referenced-by-count":2,"title":["Impact of regulatory T cell therapy on immune cell composition and fetal survival rate in abortion prone mice"],"prefix":"10.1071","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-1923","authenticated-orcid":true,"given":"F.","family":"Idali","sequence":"first","affiliation":[{"name":"AReproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Golshahi","sequence":"additional","affiliation":[{"name":"BNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Katouzian","sequence":"additional","affiliation":[{"name":"AReproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Notash Haghighat","sequence":"additional","affiliation":[{"name":"CMonoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rezaii-nia","sequence":"additional","affiliation":[{"name":"AReproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jeddi-Tehrani","sequence":"additional","affiliation":[{"name":"CMonoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"issue":"3","key":"2025102820311663100_R1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus.","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nature 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