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Gene expression was analysed using RT-PCR. Fertility of mutants was checked by standard breeding and competition breeding tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>In Pxt1\u2212\/\u2212 mice, a strong increase in the sperm DNA fragmentation index (DFI) was observed, while other sperm parameters were comparable to those of control animals. Despite enhanced DFI, mutants were fertile and able to mate in competition with wild type males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pxt1 induces cell death; thus, the higher sperm DFI of mice with targeted deletion of Pxt1 suggests some function for this gene in the elimination of male germ cells with chromatin damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Ablation of mouse Pxt1 results in enhanced DFI. In humans, the homologous PXT1 gene shares 74% similarity with the mouse gene; thus, it can be considered a candidate for mutation screening in patients with increased DFI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd23061","type":"journal-article","created":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T19:19:37Z","timestamp":1688325577000},"page":"589-600","source":"Crossref","is-referenced-by-count":2,"title":["Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice"],"prefix":"10.1071","volume":"35","author":[{"given":"Bernadetta","family":"Pawlicka","sequence":"first","affiliation":[{"name":"ALaboratory of Genetics and Evolutionism, Institute of Zoology and Biomedical Research, Jagiellonian University in Krak\u00f3w, Krak\u00f3w, 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