{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:20:32Z","timestamp":1789539632280,"version":"build-2803163510"},"reference-count":253,"publisher":"CSIRO Publishing","issue":"14","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":617,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["05219"],"award-info":[{"award-number":["05219"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Cadherins (CDH) are crucial intercellular adhesion molecules, contributing to morphogenesis and creating tissue barriers by regulating cells\u2019 movement, clustering and differentiation. In the testis, classical cadherins such as CDH1, CDH2 and CDH3 are critical to gonadogenesis by promoting the migration and the subsequent clustering of primordial germ cells with somatic cells. While CDH2 is present in both Sertoli and germ cells in rodents, CDH1 is primarily detected in undifferentiated spermatogonia. As for CDH3, its expression is mainly found in germ and pre-Sertoli cells in developing gonads until the establishment of the blood\u2013testis barrier (BTB). This barrier is made of Sertoli cells forming intercellular junctional complexes. The restructuring of the BTB allows the movement of early spermatocytes toward the apical compartment as they differentiate during a process called spermatogenesis. CDH2 is among many junctional proteins participating in this process and is regulated by several pathways. While cytokines promote the disassembly of the BTB by enhancing junctional protein endocytosis for degradation, testosterone facilitates the assembly of the BTB by increasing the recycling of endocytosed junctional proteins. Mitogen-activated protein kinases (MAPKs) are also mediators of the BTB kinetics in many chemically induced damages in the testis. In addition to regulating Sertoli cell functions, follicle stimulating hormone can also regulate the expression of CDH2. In this review, we discuss the current knowledge on regulatory mechanisms of cadherin localisation and expression in the testis.<\/jats:p>","DOI":"10.1071\/rd23084","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:30:41Z","timestamp":1694975441000},"page":"641-660","source":"Crossref","is-referenced-by-count":13,"title":["Classical cadherins in the testis: how are they regulated?"],"prefix":"10.1071","volume":"35","author":[{"given":"Ha Tuyen","family":"Nguyen","sequence":"first","affiliation":[{"name":"ABiology Department, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-8646","authenticated-orcid":true,"given":"Luc J.","family":"Martin","sequence":"additional","affiliation":[{"name":"ABiology Department, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"2025102820320196000_R1","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1091\/mbc.e06-10-0902","article-title":"Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.","volume":"18","author":"Aivatiadou","year":"2007","journal-title":"Molecular Biology of the Cell"},{"key":"2025102820320196000_R2","doi-asserted-by":"publisher","DOI":"10.1111\/and.14342","article-title":"Dietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: regulatory effects of kefir supplementation.","volume":"54","author":"Akar","year":"2022","journal-title":"Andrologia"},{"key":"2025102820320196000_R3","doi-asserted-by":"publisher","first-page":"20160","DOI":"10.1016\/S0021-9258(17)30484-2","article-title":"Increased levels of junB and c-jun mRNAs in male germ cells following testicular cell dissociation. 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