{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:54:12Z","timestamp":1788990852963,"version":"build-2803163510"},"reference-count":78,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":697,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"funder":[{"name":"USDA National Needs Fellowship","award":["USDA NIFA Grant 2019-38420-28972"],"award-info":[{"award-number":["USDA NIFA Grant 2019-38420-28972"]}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["USDA NIFA Grant 2022-67015-36371"],"award-info":[{"award-number":["USDA NIFA Grant 2022-67015-36371"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:p>Existing research has primarily focused on investigating the impacts of the maternal environment, female fertility phenotype, and genetics on pregnancy loss in dairy cattle. Recently, attention has been directed toward understanding the role the sire has on embryo quality and viability. Studies have shown there is a paternal influence on early pregnancy loss, but the specific mechanisms impacting pregnancy establishment and maintenance remain unclear. Despite clear differences that sires have on pregnancy outcomes, there is a lack of evidence regarding specifically how sires influence pregnancy. Sperm characteristics, such as motility, concentration, and morphology, have been extensively studied, but further research is needed to understand what makes one sire more or less fertile than another sire and how this affects pregnancy. To effectively address pregnancy loss, a deeper understanding of the processes involved from fertilisation to blastocyst formation is essential, particularly for understanding early pregnancy loss.<\/jats:p>","DOI":"10.1071\/rd23172","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:01:23Z","timestamp":1696827683000},"page":"43-50","source":"Crossref","is-referenced-by-count":4,"title":["Paternal determinants of early embryo development"],"prefix":"10.1071","volume":"36","author":[{"given":"Kelsey N.","family":"Lockhart","sequence":"first","affiliation":[{"name":"ADivision of Animal Sciences, University of Missouri, Columbia, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey C.","family":"Fallon","sequence":"additional","affiliation":[{"name":"ADivision of Animal Sciences, University of Missouri, Columbia, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-7314","authenticated-orcid":true,"given":"M. Sofia","family":"Ortega","sequence":"additional","affiliation":[{"name":"BDepartment of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"2025110222262919600_R1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/age.13089","article-title":"Targeted sequencing reveals candidate causal variants for dairy bull subfertility.","volume":"52","author":"Abdollahi-Arpanahi","year":"2021","journal-title":"Animal Genetics"},{"key":"2025110222262919600_R2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00791","article-title":"From sperm motility to sperm-borne microRNA signatures: new approaches to predict male fertility potential.","volume":"8","author":"Alves","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"2025110222262919600_R3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010272","article-title":"Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice.","volume":"18","author":"Ar\u00e9valo","year":"2022","journal-title":"PLoS Genetics"},{"key":"2025110222262919600_R4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/rda.12645","article-title":"The effect of sperm morphology and sire fertility on calving rate of finnish ayrshire AI bulls.","volume":"51","author":"Attia","year":"2016","journal-title":"Reproduction in Domestic Animals"},{"key":"2025110222262919600_R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110987","article-title":"The sperm centrioles.","volume":"518","author":"Avidor-Reiss","year":"2020","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2025110222262919600_R6","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s11255-015-1188-5","article-title":"Elevated levels of S100A12 in the seminal plasma of infertile men with varicocele.","volume":"48","author":"Bagheri","year":"2016","journal-title":"International Urology and Nephrology"},{"key":"2025110222262919600_R7","doi-asserted-by":"publisher","first-page":"5739","DOI":"10.3168\/jds.2009-2226","article-title":"Genetic parameters for anovulation and pregnancy loss in dairy cattle.","volume":"92","author":"Bamber","year":"2009","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/andr.12486","article-title":"Morphological defects, sperm DNA integrity, and protamination of bovine spermatozoa.","volume":"6","author":"Boe-Hansen","year":"2018","journal-title":"Andrology"},{"key":"2025110222262919600_R9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1530\/REP-08-0242","article-title":"Period of dominance of the ovulatory follicle influences embryo quality in lactating dairy cows.","volume":"137","author":"Cerri","year":"2009","journal-title":"Reproduction"},{"key":"2025110222262919600_R10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.tiv.2015.12.016","article-title":"Involvement of hypoxia-inducible factor-1\u03b1 in the oxidative stress induced by advanced glycation end products in murine Leydig cells.","volume":"32","author":"Chen","year":"2016","journal-title":"Toxicology in Vitro"},{"key":"2025110222262919600_R11","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1039\/C9FO00240E","article-title":"Potential effect of advanced glycation end products (AGEs) on spermatogenesis and sperm quality in rodents.","volume":"10","author":"Chen","year":"2019","journal-title":"Food & Function"},{"key":"2025110222262919600_R12"},{"key":"2025110222262919600_R13","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.3168\/jds.2011-4976","article-title":"Genetic merit for fertility traits in Holstein cows: II. Ovarian follicular and corpus luteum dynamics, reproductive hormones, and estrus behavior.","volume":"95","author":"Cummins","year":"2012","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R14","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.1439-0531.2008.01171.x","article-title":"Embryonic and early foetal losses in cattle and other ruminants.","volume":"43","author":"Diskin","year":"2008","journal-title":"Reproduction in Domestic Animals"},{"key":"2025110222262919600_R15","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.993561","article-title":"Identification of differentially expressed mRNAs and miRNAs in spermatozoa of bulls of varying fertility.","volume":"9","author":"Donnellan","year":"2022","journal-title":"Frontiers in Veterinary Science"},{"key":"2025110222262919600_R16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.mam.2008.08.001","article-title":"The ADAM metalloproteinases.","volume":"29","author":"Edwards","year":"2008","journal-title":"Molecular Aspects of Medicine"},{"key":"2025110222262919600_R17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/biolre\/iox065","article-title":"Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.","volume":"97","author":"Fernandez-Fuertes","year":"2017","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04678-8","article-title":"A novel atypical sperm centriole is functional during human fertilization.","volume":"9","author":"Fishman","year":"2018","journal-title":"Nature Communications"},{"key":"2025110222262919600_R19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/j.2047-2927.2014.00196.x","article-title":"Sperm protamine deficiency correlates with sperm DNA damage in Bos indicus bulls.","volume":"2","author":"Fortes","year":"2014","journal-title":"Andrology"},{"key":"2025110222262919600_R20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.7313\/upo9781907284991.023","article-title":"Interaction of sperm with the zona pellucida during fertilization.","volume":"67","author":"Gadella","year":"2010","journal-title":"Society for Reproduction and Fertility Supplement"},{"key":"2025110222262919600_R21","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.theriogenology.2005.06.011","article-title":"Relationship between heat stress during the peri-implantation period and early fetal loss in dairy cattle.","volume":"65","author":"Garc\u00eda-Ispierto","year":"2006","journal-title":"Theriogenology"},{"key":"2025110222262919600_R22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.fertnstert.2010.06.053","article-title":"Protamine 1 to protamine 2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm.","volume":"95","author":"Garc\u00eda-Peir\u00f3","year":"2011","journal-title":"Fertility and Sterility"},{"key":"2025110222262919600_R23","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1126\/science.3576213","article-title":"Sequence-specific packaging of DNA in human sperm chromatin.","volume":"236","author":"Gatewood","year":"1987","journal-title":"Science"},{"key":"2025110222262919600_R24","doi-asserted-by":"publisher","first-page":"6660","DOI":"10.3168\/jds.2018-16011","article-title":"Influence of on-farm measurements for heat stress indicators on dairy cow productivity, female fertility, and health.","volume":"102","author":"Gernand","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R25","doi-asserted-by":"publisher","first-page":"14026","DOI":"10.3390\/ijms131114026","article-title":"Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells.","volume":"13","author":"Gonz\u00e1lez-Mar\u00edn","year":"2012","journal-title":"International Journal of Molecular Sciences"},{"key":"2025110222262919600_R26","doi-asserted-by":"publisher","first-page":"4139","DOI":"10.1073\/pnas.1321569111","article-title":"Fine mapping of genome activation in bovine embryos by RNA sequencing.","volume":"111","author":"Graf","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2025110222262919600_R27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55868-3","article-title":"Characterization and functional roles of paternal RNAs in 2\u20134 cell bovine embryos.","volume":"9","author":"Gross","year":"2019","journal-title":"Scientific Reports"},{"key":"2025110222262919600_R28","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-016-0454-6","article-title":"Unravelling the genomic architecture of bull fertility in Holstein cattle.","volume":"17","author":"Han","year":"2016","journal-title":"BMC Genetics"},{"key":"2025110222262919600_R29","doi-asserted-by":"publisher","first-page":"s63","DOI":"10.1017\/S1751731118000319","article-title":"Review: Integrating a semen quality control program and sire fertility at a large artificial insemination organization.","volume":"12","author":"Harstine","year":"2018","journal-title":"Animal"},{"key":"2025110222262919600_R30","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/1098-2795(200008)56:4&lt;520::AID-MRD10&gt;3.0.CO;2-0","article-title":"Excessive concentration of glucose during in vitro maturation impairs the developmental competence of bovine oocytes after in vitro fertilization: relevance to intracellular reactive oxygen species and glutathione contents.","volume":"56","author":"Hashimoto","year":"2000","journal-title":"Molecular Reproduction & Development"},{"key":"2025110222262919600_R31","doi-asserted-by":"publisher","first-page":"E24","DOI":"10.2527\/2004.8213_supplE24x","article-title":"Preovulatory, postovulatory, and postmaternal recognition effects of concentrations of progesterone on embryonic survival in the cow.","volume":"82","author":"Inskeep","year":"2004","journal-title":"Journal of Animal Science"},{"key":"2025110222262919600_R32","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/bies.10038","article-title":"Histone ubiquitination: a tagging tail unfolds?: review articles.","volume":"24","author":"Jason","year":"2002","journal-title":"BioEssays"},{"key":"2025110222262919600_R33","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.3168\/jds.2007-0946","article-title":"Modeling nuisance variables for prediction of service sire fertility.","volume":"91","author":"Kuhn","year":"2008","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R34","doi-asserted-by":"publisher","first-page":"5824","DOI":"10.3168\/jds.2016-12484","article-title":"Sperm viability, reactive oxygen species, and DNA fragmentation index combined can discriminate between above- and below-average fertility bulls.","volume":"100","author":"Kumaresan","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R35","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1017\/S1751731114003140","article-title":"Sire effect on early and late embryonic death in French Holstein cattle.","volume":"9","author":"Ledoux","year":"2015","journal-title":"Animal"},{"key":"2025110222262919600_R36","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy023","article-title":"Comprehensive mitochondrial DNA analysis and IVF outcome.","volume":"2018","author":"Lledo","year":"2018","journal-title":"Human Reproduction Open"},{"key":"2025110222262919600_R37","doi-asserted-by":"publisher","DOI":"10.1530\/REP-23-0030","article-title":"Sire modulates developmental kinetics and transcriptome of the bovine embryo.","volume":"1","author":"Lockhart","year":"2023","journal-title":"Reproduction"},{"key":"2025110222262919600_R38","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.theriogenology.2004.02.005","article-title":"Progesterone supplementation during the early fetal period reduces pregnancy loss in high-yielding dairy cattle.","volume":"62","author":"L\u00f3pez-Gatius","year":"2004","journal-title":"Theriogenology"},{"key":"2025110222262919600_R39","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.2527\/jas1983.5651186x","article-title":"Fertilization failure and embryonic mortality in parous and nonparous beef cattle.","volume":"56","author":"Maurer","year":"1983","journal-title":"Journal of Animal Science"},{"key":"2025110222262919600_R40","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/mrd.1080310303","article-title":"Highly acetylated H4 is associated with histone displacement in rat spermatids.","volume":"31","author":"Meistrich","year":"1992","journal-title":"Molecular Reproduction & Development"},{"key":"2025110222262919600_R41","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1095\/biolreprod61.5.1198","article-title":"Control of gene expression at the onset of bovine embryonic development.","volume":"61","author":"Memili","year":"1999","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R42","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1530\/REP-13-0017","article-title":"Reactive oxygen species production and redox state in parthenogenetic and sperm-mediated bovine oocyte activation.","volume":"145","author":"Morado","year":"2013","journal-title":"Reproduction"},{"key":"2025110222262919600_R43","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.livsci.2010.08.010","article-title":"Effect of cryopreservation on sperm chromatin integrity and fertilizing potential in bovine semen.","volume":"136","author":"Mukhopadhyay","year":"2011","journal-title":"Livestock Science"},{"key":"2025110222262919600_R44","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-020-6758-y","article-title":"Whole-genome homozygosity mapping reveals candidate regions affecting bull fertility in US Holstein cattle.","volume":"21","author":"Nani","year":"2020","journal-title":"BMC Genomics"},{"issue":"2","key":"2025110222262919600_R45","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1242\/dev.113.2.551","article-title":"The origin of reactive oxygen species in mouse embryos cultured in vitro.","volume":"113","author":"Nasr-Esfahani","year":"1991","journal-title":"Development"},{"key":"2025110222262919600_R46","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.fertnstert.2012.08.035","article-title":"Phospholipase C\u03b6 rescues failed oocyte activation in a prototype of male factor infertility.","volume":"99","author":"Nomikos","year":"2013","journal-title":"Fertility and Sterility"},{"key":"2025110222262919600_R47","doi-asserted-by":"publisher","first-page":"6135","DOI":"10.3168\/jds.2010-3875","article-title":"Evaluations for service-sire conception rate for heifer and cow inseminations with conventional and sexed semen.","volume":"94","author":"Norman","year":"2011","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R48","doi-asserted-by":"publisher","first-page":"7262","DOI":"10.3168\/jds.2020-19900","article-title":"Sire contribution to fertilization failure and early embryo survival in cattle.","volume":"104","author":"O\u2019Callaghan","year":"2021","journal-title":"Journal of Dairy Science"},{"key":"2025110222262919600_R49","doi-asserted-by":"publisher","first-page":"583","DOI":"10.4103\/1008-682x.153303","article-title":"Redox regulation of mammalian sperm capacitation.","volume":"17","author":"O\u2019Flaherty","year":"2015","journal-title":"Asian Journal of Andrology"},{"key":"2025110222262919600_R50","doi-asserted-by":"publisher","first-page":"F67","DOI":"10.1530\/REP-22-0200","article-title":"Oxidative Stress and Reproductive Function: The protection of mammalian spermatozoa against oxidative stress.","volume":"164","author":"O\u2019Flaherty","year":"2022","journal-title":"Reproduction"},{"key":"2025110222262919600_R51","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1093\/biolre\/ioy141","article-title":"Influences of sire conception rate on pregnancy establishment in dairy cattle.","volume":"99","author":"Ortega","year":"2018","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R52","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0445-8","article-title":"The art of oocyte meiotic arrest regulation.","volume":"17","author":"Pan","year":"2019","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2025110222262919600_R53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004044","article-title":"A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle.","volume":"10","author":"Pausch","year":"2014","journal-title":"PLoS Genetics"},{"key":"2025110222262919600_R54","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-2-19","article-title":"Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility.","volume":"2","author":"Peddinti","year":"2008","journal-title":"BMC Systems Biology"},{"key":"2025110222262919600_R55","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0301-6226(03)00145-3","article-title":"Fertility in the high-producing dairy cow.","volume":"86","author":"Pryce","year":"2004","journal-title":"Livestock Production Science"},{"key":"2025110222262919600_R56","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/molehr\/2.11.889","article-title":"Preimplantation embryology: The molecular genetics of the zona pellucida: mouse mutations and infertility.","volume":"2","author":"Rankin","year":"1996","journal-title":"Molecular Human Reproduction"},{"key":"2025110222262919600_R57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.theriogenology.2020.10.008","article-title":"The impaired development of sheep ICSI derived embryos is not related to centriole dysfunction.","volume":"159","author":"Ressaissi","year":"2021","journal-title":"Theriogenology"},{"key":"2025110222262919600_R58","first-page":"173","article-title":"Effects of sperm chromatin integrity on fertilization rate and embryo quality following intracytoplasmic sperm injection.","volume":"1","author":"Sadeghi","year":"2009","journal-title":"Avicenna Journal of Medical Biotechnology"},{"key":"2025110222262919600_R59","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.bbamcr.2013.03.010","article-title":"Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNA.","volume":"1833","author":"Sato","year":"2013","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Molecular Cell Research"},{"key":"2025110222262919600_R60","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1080\/19396368.2018.1444816","article-title":"Current status of sperm functional genomics and its diagnostic potential of fertility in bovine (Bos taurus).","volume":"64","author":"Selvaraju","year":"2018","journal-title":"Systems Biology in Reproductive Medicine"},{"key":"2025110222262919600_R61","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1530\/REP-13-0123","article-title":"Influence of bovine sperm DNA fragmentation and oxidative stress on early embryo in vitro development outcome.","volume":"146","author":"Sim\u00f5es","year":"2013","journal-title":"Reproduction"},{"key":"2025110222262919600_R62","doi-asserted-by":"publisher","first-page":"E5261","DOI":"10.1073\/pnas.1605844113","article-title":"Autophagy and ubiquitin\u2013proteasome system contribute to sperm mitophagy after mammalian fertilization.","volume":"113","author":"Song","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2025110222262919600_R63","doi-asserted-by":"publisher","first-page":"s121","DOI":"10.1017\/S1751731118000253","article-title":"Review: Sperm\u2013oocyte interactions and their implications for bull fertility, with emphasis on the ubiquitin\u2013proteasome system.","volume":"12","author":"Sutovsky","year":"2018","journal-title":"Animal"},{"key":"2025110222262919600_R64","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/46466","article-title":"Ubiquitin tag for sperm mitochondria.","volume":"402","author":"Sutovsky","year":"1999","journal-title":"Nature"},{"key":"2025110222262919600_R65","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1095\/biolreprod63.2.582","article-title":"Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos.","volume":"63","author":"Sutovsky","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R66","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1095\/biolreprod.102.010975","article-title":"Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control.","volume":"69","author":"Thompson","year":"2003","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R67","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/(SICI)1098-2795(199705)47:1&lt;47::AID-MRD7&gt;3.0.CO;2-Q","article-title":"Relationship between timing of development, morula morphology, and cell allocation to inner cell mass and trophectoderm in in vitro-produced bovine embryos.","volume":"47","author":"van Soom","year":"1997","journal-title":"Molecular Reproduction & Development"},{"key":"2025110222262919600_R68","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1093\/biolre\/ioy210","article-title":"Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct.","volume":"100","author":"Voronina","year":"2019","journal-title":"Biology of Reproduction"},{"key":"2025110222262919600_R69","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.874371","article-title":"Characteristics of miRNAs present in bovine sperm and associations with differences in fertility.","volume":"13","author":"Werry","year":"2022","journal-title":"Frontiers in Endocrinology"},{"key":"2025110222262919600_R70","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.theriogenology.2016.04.037","article-title":"Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows.","volume":"86","author":"Wiltbank","year":"2016","journal-title":"Theriogenology"},{"key":"2025110222262919600_R71","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0300-9084(98)80018-7","article-title":"Nuclear basic proteins in spermiogenesis.","volume":"80","author":"Wouters-Tyrou","year":"1998","journal-title":"Biochimie"},{"key":"2025110222262919600_R72","doi-asserted-by":"publisher","first-page":"12164","DOI":"10.1074\/jbc.M609132200","article-title":"PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization.","volume":"282","author":"Wu","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"2025110222262919600_R73","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.theriogenology.2019.12.020","article-title":"The age of the bull influences the transcriptome and epigenome of blastocysts produced by IVF.","volume":"144","author":"Wu","year":"2020","journal-title":"Theriogenology"},{"key":"2025110222262919600_R74","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1093\/humrep\/dez153","article-title":"Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa.","volume":"34","author":"Xavier","year":"2019","journal-title":"Human Reproduction"},{"key":"2025110222262919600_R75","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1093\/humrep\/13.4.998","article-title":"Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos.","volume":"13","author":"Yang","year":"1998","journal-title":"Human Reproduction"},{"key":"2025110222262919600_R76","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1128\/mcb.7.6.2173-2179.1987","article-title":"Mouse protamine 2 is synthesized as a precursor whereas mouse protamine 1 is not.","volume":"7","author":"Yelick","year":"1987","journal-title":"Molecular and Cellular Biology"},{"key":"2025110222262919600_R77"},{"key":"2025110222262919600_R78","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1242\/dev.131755","article-title":"Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development.","volume":"143","author":"Yuan","year":"2016","journal-title":"Development"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/36\/2\/43\/1325907\/rd23172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/36\/2\/43\/1325907\/rd23172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:26:35Z","timestamp":1762140395000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/36\/2\/43\/194337\/Paternal-determinants-of-early-embryo-development"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,12,8]]}},"URL":"https:\/\/doi.org\/10.1071\/rd23172","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]}}}