{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:32:30Z","timestamp":1771572750796,"version":"3.50.1"},"reference-count":104,"publisher":"CSIRO Publishing","issue":"2","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":689,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"N8 agri-food pump priming"},{"name":"LTHT"},{"name":"QR GCRF"},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R017522\/1, BB\/X007332\/1"],"award-info":[{"award-number":["BB\/R017522\/1, BB\/X007332\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["227178\/Z\/23\/Z"],"award-info":[{"award-number":["227178\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,8]]},"abstract":"<jats:p>Communication between the maternal endometrium and developing embryo\/conceptus is critical to support successful pregnancy to term. Studying the peri-implantation period of pregnancy is critical as this is when most pregnancy loss occurs in cattle. Our current understanding of these interactions is limited, due to the lack of appropriate in vitro models to assess these interactions. The endometrium is a complex and heterogeneous tissue that is regulated in a transcriptional and translational manner throughout the oestrous cycle. While there are in vitro models to study endometrial function, they are static and 2D in nature or explant models and are limited in how well they recapitulate the in vivo endometrium. Recent developments in organoid systems, microfluidic approaches, extracellular matrix biology, and in silico approaches provide a new opportunity to develop in vitro systems that better model the in vivo scenario. This will allow us to investigate in a more high-throughput manner the fundamental molecular interactions that are required for successful pregnancy in cattle.<\/jats:p>","DOI":"10.1071\/rd23181","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:06:35Z","timestamp":1697486795000},"page":"81-92","source":"Crossref","is-referenced-by-count":6,"title":["Understanding conceptus\u2013maternal interactions: what tools do we need to develop?"],"prefix":"10.1071","volume":"36","author":[{"given":"Zenab","family":"Butt","sequence":"first","affiliation":[{"name":"ADiscovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidee","family":"Tinning","sequence":"additional","affiliation":[{"name":"ADiscovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"BComputational and Molecular Evolutionary Biology Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2RD, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Fenn","sequence":"additional","affiliation":[{"name":"BComputational and Molecular Evolutionary Biology Group, School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2RD, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Alberio","sequence":"additional","affiliation":[{"name":"CSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Forde","sequence":"additional","affiliation":[{"name":"ADiscovery and Translational Sciences Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds LS2 9JT, UK."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2025110222263482600_R1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08720-4","article-title":"RNA-Sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy.","volume":"23","author":"Adhikari","year":"2022","journal-title":"BMC Genomics"},{"issue":"10","key":"2025110222263482600_R2","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1093\/humrep\/deab186","article-title":"Three-dimensional microengineered vascularised endometrium-on-a-chip.","volume":"36","author":"Ahn","year":"2021","journal-title":"Human Reproduction"},{"key":"2025110222263482600_R3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmpb.2018.06.010","article-title":"Fetal health status prediction based on maternal clinical history using machine learning techniques.","volume":"163","author":"Akbulut","year":"2018","journal-title":"Computer Methods and Programs in Biomedicine"},{"key":"2025110222263482600_R4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.placenta.2020.10.015","article-title":"Maternal thyroid profile in first and second trimester of pregnancy is correlated with gestational diabetes mellitus through machine learning.","volume":"103","author":"Araya","year":"2021","journal-title":"Placenta"},{"key":"2025110222263482600_R5","doi-asserted-by":"publisher","DOI":"10.3389\/fanim.2022.939876","article-title":"Endometrial gene expression in response to lipopolysaccharide between estrous cycle phases and uterine horns in cattle.","volume":"3","author":"Ault-Seay","year":"2022","journal-title":"Frontiers in Animal Science"},{"issue":"10","key":"2025110222263482600_R6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s11626-020-00521-x","article-title":"Secreted protein of Ly6 domain 1 enhanced bovine trophoblastic cell migration activity.","volume":"56","author":"Awad","year":"2020","journal-title":"In Vitro Cellular & Developmental Biology \u2013 Animal"},{"issue":"5","key":"2025110222263482600_R7","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.cell.2014.01.023","article-title":"Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation.","volume":"156","author":"Bedzhov","year":"2014","journal-title":"Cell"},{"issue":"7","key":"2025110222263482600_R8","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/ng1590","article-title":"Identification of hundreds of conserved and nonconserved human microRNAs.","volume":"37","author":"Bentwich","year":"2005","journal-title":"Nature Genetics"},{"issue":"6","key":"2025110222263482600_R9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1600-0897.2012.01106.x","article-title":"Explants of intact endometrium to model bovine innate immunity and inflammation ex vivo.","volume":"67","author":"Borges","year":"2012","journal-title":"American Journal of Reproductive Immunology"},{"issue":"1","key":"2025110222263482600_R10","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-5-53","article-title":"Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol.","volume":"5","author":"Brooks","year":"2014","journal-title":"Journal of Animal Science and Biotechnology"},{"issue":"7","key":"2025110222263482600_R11","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1096\/fj.201601146R","article-title":"Expression and trafficking of placental microRNAs at the feto-maternal interface.","volume":"31","author":"Chang","year":"2017","journal-title":"The FASEB Journal"},{"issue":"1","key":"2025110222263482600_R12","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-07712-0","article-title":"Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.","volume":"22","author":"Chankeaw","year":"2021","journal-title":"BMC Genomics"},{"issue":"3","key":"2025110222263482600_R13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1093\/molbev\/msaa274","article-title":"Evolution of embryo implantation was enabled by the origin of decidual stromal cells in eutherian mammals.","volume":"38","author":"Chavan","year":"2021","journal-title":"Molecular Biology and Evolution"},{"issue":"3","key":"2025110222263482600_R14","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/s43032-022-01071-1","article-title":"Combining machine learning with metabolomic and embryologic data improves embryo implantation prediction.","volume":"30","author":"Cheredath","year":"2023","journal-title":"Reproductive Sciences"},{"issue":"1","key":"2025110222263482600_R15","doi-asserted-by":"publisher","DOI":"10.1038\/srep20927","article-title":"How tissue mechanical properties affect enteric neural crest cell migration.","volume":"6","author":"Chevalier","year":"2016","journal-title":"Scientific Reports"},{"issue":"6643","key":"2025110222263482600_R16","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn3943","article-title":"Evolutionary constraint and innovation across hundreds of placental mammals.","volume":"380","author":"Christmas","year":"2023","journal-title":"Science"},{"issue":"4","key":"2025110222263482600_R17","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bpa.2011.08.006","article-title":"In silico modelling of physiologic systems.","volume":"25","author":"Colquitt","year":"2011","journal-title":"Best Practice & Research Clinical Anaesthesiology"},{"key":"2025110222263482600_R100","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.3390\/ijms17081322","article-title":"Telocytes and their extracellular vesicles\u2014evidence and hypotheses.","volume":"17","author":"Cretoiu","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"2025110222263482600_R18","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092718","article-title":"Toll-like receptor 4 and MYD88-dependent signaling mechanisms of the innate immune system are essential for the response to lipopolysaccharide by epithelial and stromal cells of the bovine endometrium.","volume":"86","author":"Cronin","year":"2012","journal-title":"Biology of Reproduction"},{"issue":"3","key":"2025110222263482600_R19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/10408360801973244","article-title":"The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis.","volume":"45","author":"Cruz-Munoz","year":"2008","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"issue":"12","key":"2025110222263482600_R20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221526120","article-title":"Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta.","volume":"120","author":"Davenport","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"2025110222263482600_R21","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab054","article-title":"Endometrium on-a-chip reveals insulin- and glucose-induced alterations in the transcriptome and proteomic secretome.","volume":"162","author":"De Bem","year":"2021","journal-title":"Endocrinology"},{"issue":"121","key":"2025110222263482600_R22","doi-asserted-by":"publisher","DOI":"10.3791\/55168","article-title":"Isolation of mouse endometrial epithelial and stromal cells for in vitro decidualization.","author":"De Clercq","year":"2017","journal-title":"Journal of Visualized Experiments: JoVE"},{"issue":"10","key":"2025110222263482600_R23","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1002\/ijc.23925","article-title":"Stromal myofibroblasts are drivers of invasive cancer growth.","volume":"123","author":"De Wever","year":"2008","journal-title":"International Journal of Cancer"},{"issue":"8","key":"2025110222263482600_R25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/molehr\/gas013","article-title":"The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes.","volume":"18","author":"Donker","year":"2012","journal-title":"Molecular Human Reproduction"},{"key":"2025110222263482600_R26","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-65","article-title":"Bovine endometrial stromal cells display osteogenic properties.","volume":"6","author":"Donofrio","year":"2008","journal-title":"Reproductive Biology and Endocrinology: RB&E"},{"issue":"3","key":"2025110222263482600_R24","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s11259-023-10130-0","article-title":"Generation of a novel three-dimensional scaffold-based model of the bovine endometrium.","volume":"47","author":"D\u00edez","year":"2023","journal-title":"Veterinary Research Communications"},{"issue":"12","key":"2025110222263482600_R27","doi-asserted-by":"publisher","first-page":"11798","DOI":"10.3168\/jds.2019-17176","article-title":"Symposium review: predicting pregnancy loss in dairy cattle.","volume":"102","author":"Ealy","year":"2019","journal-title":"Journal of Dairy Science"},{"issue":"4","key":"2025110222263482600_R28","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification.","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"issue":"4","key":"2025110222263482600_R29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041478","article-title":"FOXL2 is a progesterone target gene in the endometrium of ruminants.","volume":"21","author":"Eozenou","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"2\u20134","key":"2025110222263482600_R99","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1387\/ijdb.130344ts","article-title":"Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization.","volume":"58","author":"Filant","year":"2014","journal-title":"International Journal of Developmental Biology"},{"issue":"2","key":"2025110222263482600_R30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1262\/jrd.2011-021","article-title":"Transcriptomic analysis of the bovine endometrium: what is required to establish uterine receptivity to implantation in cattle?","volume":"58","author":"Forde","year":"2012","journal-title":"Journal of Reproduction and Development"},{"key":"2025110222263482600_R109","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1071\/RD14348","article-title":"Lactation-Induced changes in metabolic status and follicular-fluid metabolomic profile in postpartum dairy cows.","volume":"28","author":"Forde","year":"2016","journal-title":"Reproduction, Fertility and Development"},{"issue":"24","key":"2025110222263482600_R31","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance.","volume":"123","author":"Frantz","year":"2010","journal-title":"Journal of Cell Science"},{"issue":"2","key":"2025110222263482600_R32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1530\/rep.0.1240289","article-title":"Evidence that absence of endometrial gland secretions in uterine gland knockout ewes compromises conceptus survival and elongation.","volume":"124","author":"Gray","year":"2002","journal-title":"Reproduction"},{"issue":"8","key":"2025110222263482600_R33","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.placenta.2015.06.001","article-title":"Changes in endometrial ezrin and cytokeratin 18 expression during bovine implantation and in caruncular endometrial spheroids in vitro.","volume":"36","author":"Haeger","year":"2015","journal-title":"Placenta"},{"issue":"2","key":"2025110222263482600_R34","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12334","article-title":"Explant culture: an advantageous method for isolation of mesenchymal stem cells from human tissues.","volume":"50","author":"Hendijani","year":"2017","journal-title":"Cell Proliferation"},{"key":"2025110222263482600_R35","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/186041","article-title":"Circulating C19MC MicroRNAs in preeclampsia, gestational hypertension, and fetal growth restriction.","volume":"2013","author":"Hromadnikova","year":"2013","journal-title":"Mediators of Inflammation"},{"issue":"2","key":"2025110222263482600_R36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171756","article-title":"First trimester screening of circulating C19MC microRNAs and the evaluation of their potential to predict the onset of preeclampsia and IUGR.","volume":"12","author":"Hromadnikova","year":"2017","journal-title":"PLoS ONE"},{"key":"2025110222263482600_R37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.bbrc.2022.03.017","article-title":"Establishment and characterization of a sheep endometrial epithelial cell line.","volume":"603","author":"Hu","year":"2022","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"2025110222263482600_R38","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.rbmo.2021.02.015","article-title":"Deep learning neural network analysis of human blastocyst expansion from time-lapse image files.","volume":"42","author":"Huang","year":"2021","journal-title":"Reproductive BioMedicine Online"},{"issue":"6","key":"2025110222263482600_R39","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600502","article-title":"Matrix-bound nanovesicles within ECM bioscaffolds.","volume":"2","author":"Huleihel","year":"2016","journal-title":"Science Advances"},{"issue":"4","key":"2025110222263482600_R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106339","article-title":"MicroRNAs emerging coordinate with placental mammals alter pathways in endometrial epithelia important for endometrial function.","volume":"26","author":"Hume","year":"2023","journal-title":"iScience"},{"issue":"5","key":"2025110222263482600_R41","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051047","article-title":"Molecular evolution of CatSper in mammals and function of sperm hyperactivation in gray short-tailed opossum.","volume":"10","author":"Hwang","year":"2021","journal-title":"Cells"},{"issue":"4","key":"2025110222263482600_R42","doi-asserted-by":"publisher","DOI":"10.3390\/genes11040376","article-title":"Mother and embryo cross-communication.","volume":"11","author":"Idelevich","year":"2020","journal-title":"Genes"},{"issue":"1","key":"2025110222263482600_R43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11259-020-09770-3","article-title":"Improved filtration method to isolate pure populations of primary bovine endometrial epithelial and stromal cells for immunological studies.","volume":"44","author":"Kelly","year":"2020","journal-title":"Veterinary Research Communications"},{"issue":"4","key":"2025110222263482600_R44","doi-asserted-by":"publisher","first-page":"351","DOI":"10.12717\/DR.2017.21.4.351","article-title":"A review of mechanisms of implantation.","volume":"21","author":"Kim","year":"2017","journal-title":"Development & Reproduction"},{"issue":"4","key":"2025110222263482600_R45","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002123R","article-title":"Single-cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium.","volume":"35","author":"Kirkwood","year":"2021","journal-title":"FASEB Journal"},{"key":"2025110222263482600_R106","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fphar.2018.00006","article-title":"Three-dimensional in vitro cell culture models in drug discovery and drug repositioning.","volume":"9","author":"Langhans","year":"2018","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"2025110222263482600_R46","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-154","article-title":"New insights into mechanisms behind miscarriage.","volume":"11","author":"Larsen","year":"2013","journal-title":"BMC Medicine"},{"issue":"5","key":"2025110222263482600_R47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ccr.2006.03.030","article-title":"Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.","volume":"9","author":"Lee","year":"2006","journal-title":"Cancer Cell"},{"issue":"6","key":"2025110222263482600_R48","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1007\/s10616-016-9994-x","article-title":"The bovine endometrial epithelial cells promote the differentiation of trophoblast stem-like cells to binucleate trophoblast cells.","volume":"68","author":"Li","year":"2016","journal-title":"Cytotechnology"},{"key":"2025110222263482600_R49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.842607","article-title":"Gradient boosting machine learning model for defective endometrial receptivity prediction by macrophage-endometrium interaction modules.","volume":"13","author":"Li","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"2025110222263482600_R50","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.theriogenology.2013.09.021","article-title":"The ART of studying early embryo development: progress and challenges in ruminant embryo culture.","volume":"81","author":"Lonergan","year":"2014","journal-title":"Theriogenology"},{"key":"2025110222263482600_R108","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s42003-020-0763-1","article-title":"Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window.","volume":"3","author":"Lucas","year":"2020","journal-title":"Communications Biology"},{"issue":"5","key":"2025110222263482600_R53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177811","article-title":"Predicting congenital heart defects: a comparison of three data mining methods.","volume":"12","author":"Luo","year":"2017","journal-title":"PLoS ONE"},{"issue":"4","key":"2025110222263482600_R54","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.celrep.2014.12.052","article-title":"Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy.","volume":"10","author":"Lynch","year":"2015","journal-title":"Cell Reports"},{"key":"2025110222263482600_R51","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.639688","article-title":"A natural xenogeneic endometrial extracellular matrix hydrogel toward improving current human in vitro models and future in vivo applications.","volume":"9","author":"L\u00f3pez-Mart\u00ednez","year":"2021","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"1","key":"2025110222263482600_R55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1530\/REP-12-0253","article-title":"Polarised bovine endometrial epithelial cells vectorially secrete prostaglandins and chemotactic factors under physiological and pathological conditions.","volume":"145","author":"MacKintosh","year":"2013","journal-title":"Reproduction"},{"issue":"7","key":"2025110222263482600_R104","doi-asserted-by":"publisher","first-page":"skac123","DOI":"10.1093\/jas\/skac123","article-title":"Ruminant conceptus-maternal interactions: interferon-tau and beyond.","volume":"100","author":"Mathew","year":"2022","journal-title":"Journal of Animal Science"},{"issue":"5","key":"2025110222263482600_R57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14569\/IJACSA.2018.090501","article-title":"Cardiotocographic diagnosis of fetal health based on multiclass morphologic pattern predictions using deep learning classification.","volume":"9","author":"Miao","year":"2018","journal-title":"International Journal of Advanced Computer Science and Applications"},{"key":"2025110222263482600_R58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69584","article-title":"Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes.","volume":"10","author":"Mika","year":"2021","journal-title":"eLife"},{"key":"2025110222263482600_R59","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74297","article-title":"Gene expression phylogenies and ancestral transcriptome reconstruction resolves major transitions in the origins of pregnancy.","volume":"11","author":"Mika","year":"2022","journal-title":"eLife"},{"issue":"2","key":"2025110222263482600_R102","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1530\/REP-07-0415","article-title":"Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle.","volume":"135","author":"Mitko","year":"2008","journal-title":"Reproduction"},{"key":"2025110222263482600_R60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.placenta.2020.07.001","article-title":"Placental miRNAs in feto-maternal communication mediated by extracellular vesicles.","volume":"102","author":"Morales-Prieto","year":"2020","journal-title":"Placenta"},{"key":"2025110222263482600_R61","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-1-0716-1246-0_6","article-title":"Isolation, Culture, and Characterization of Primary Bovine Endometrial, Epithelial, and Stromal Cells for 3D In Vitro Tissue Models.","volume":"2273","author":"Murillo","year":"2021","journal-title":"Methods in Molecular Biology"},{"key":"2025110222263482600_R62","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00086","article-title":"The role of the extracellular matrix in cancer stemness.","volume":"7","author":"Nallanthighal","year":"2019","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"3","key":"2025110222263482600_R107","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3390\/cancers15030635","article-title":"Organ-on-a-chip and microfluidic platforms for oncology in the UK.","volume":"15","author":"Nolan","year":"2023","journal-title":"Cancers"},{"issue":"13","key":"2025110222263482600_R63","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1177\/1535370220938741","article-title":"The role of extracellular matrix in normal and pathological pregnancy: future applications of microphysiological systems in reproductive medicine.","volume":"245","author":"O\u2019Connor","year":"2020","journal-title":"Experimental Biology and Medicine"},{"issue":"3","key":"2025110222263482600_R64","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1530\/REP-18-0188","article-title":"Blastocyst-induced changes in the bovine endometrial transcriptome.","volume":"156","author":"Passaro","year":"2018","journal-title":"Reproduction"},{"issue":"5","key":"2025110222263482600_R65","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.stem.2023.04.003","article-title":"Bovine blastocyst-like structures derived from stem cell cultures.","volume":"30","author":"Pinz\u00f3n-Arteaga","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"10","key":"2025110222263482600_R66","doi-asserted-by":"publisher","DOI":"10.3390\/mi12101250","article-title":"Modelling human physiology on-chip: historical perspectives and future directions.","volume":"12","author":"Pun","year":"2021","journal-title":"Micromachines"},{"issue":"3","key":"2025110222263482600_R105","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jcyt.2017.11.013","article-title":"Variation in primary and culture-expanded cells derived from connective tissue progenitors in human bone marrow space, bone trabecular surface and adipose tissue.","volume":"20","author":"Qadan","year":"2018","journal-title":"Cytotherapy"},{"issue":"3","key":"2025110222263482600_R67","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201977R","article-title":"Machine-learning methods applied to integrated transcriptomic data from bovine blastocysts and elongating conceptuses to identify genes predictive of embryonic competence.","volume":"37","author":"Rabaglino","year":"2023","journal-title":"The FASEB Journal"},{"key":"2025110222263482600_R69","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2019.106251","article-title":"Pregnancy loss in beef cattle: a meta-analysis.","volume":"212","author":"Reese","year":"2020","journal-title":"Animal Reproduction Science"},{"key":"2025110222263482600_R70","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.711381","article-title":"From donor to the lab: a fascinating journey of primary cell lines.","volume":"9","author":"Richter","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"1","key":"2025110222263482600_R71","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0616-0","article-title":"Isolation and characterization of equine endometrial mesenchymal stromal cells.","volume":"8","author":"Rink","year":"2017","journal-title":"Stem Cell Research & Therapy"},{"key":"2025110222263482600_R72","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.actbio.2020.07.002","article-title":"Stem cell derived extracellular vesicles for vascular elastic matrix regenerative repair.","volume":"113","author":"Sajeesh","year":"2020","journal-title":"Acta Biomaterialia"},{"issue":"3","key":"2025110222263482600_R73","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.100180","article-title":"Coculture system that mimics in vivo attachment processes in bovine trophoblast cells.","volume":"87","author":"Sakurai","year":"2012","journal-title":"Biology of Reproduction"},{"key":"2025110222263482600_R75","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.matbio.2017.10.007","article-title":"Proteases and glycosidases on the surface of exosomes: newly discovered mechanisms for extracellular remodeling.","volume":"75\u201376","author":"Sanderson","year":"2019","journal-title":"Matrix Biology: Journal of the International Society for Matrix Biology"},{"key":"2025110222263482600_R76","doi-asserted-by":"publisher","DOI":"10.1101\/2023.06.13.544813","article-title":"Single-cell transcriptional landscapes of bovine peri-implantation development.","author":"Scatolin","year":"2023","journal-title":"bioRxiv"},{"issue":"1","key":"2025110222263482600_R77","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00441-009-0892-9","article-title":"Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms.","volume":"339","author":"Schmidt","year":"2010","journal-title":"Cell and Tissue Research"},{"issue":"1","key":"2025110222263482600_R78","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1530\/REP-16-0237","article-title":"Dynamic remodeling of endometrial extracellular matrix regulates embryo receptivity in cattle.","volume":"153","author":"Scolari","year":"2016","journal-title":"Reproduction"},{"issue":"5","key":"2025110222263482600_R79","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050743","article-title":"Omics and artificial intelligence to improve in vitro fertilization (IVF) success: a proposed protocol.","volume":"11","author":"Siristatidis","year":"2021","journal-title":"Diagnostics"},{"issue":"4","key":"2025110222263482600_R80","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2527\/af.2013-0033","article-title":"Early pregnancy: concepts, challenges, and potential solutions.","volume":"3","author":"Spencer","year":"2013","journal-title":"Animal Frontiers"},{"issue":"5","key":"2025110222263482600_R101","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1055\/s-0034-1376354","article-title":"Biological roles of uterine glands in pregnancy.","volume":"32","author":"Spencer","year":"2014","journal-title":"Seminars in Reproductive Medicine"},{"issue":"7","key":"2025110222263482600_R81","doi-asserted-by":"publisher","first-page":"5941","DOI":"10.3168\/jds.2015-10070","article-title":"The role of progesterone and conceptus-derived factors in uterine biology during early pregnancy in ruminants.","volume":"99","author":"Spencer","year":"2016","journal-title":"Journal of Dairy Science"},{"issue":"5","key":"2025110222263482600_R82","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/humupd\/dml033","article-title":"The human endometrium as a fertility-determining factor.","volume":"12","author":"Strowitzki","year":"2006","journal-title":"Human Reproduction Update"},{"issue":"1","key":"2025110222263482600_R74","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/biolre\/ioz060","article-title":"Bovine endometrium responds differentially to age-matched short and long conceptuses.","volume":"101","author":"S\u00e1nchez","year":"2019","journal-title":"Biology of Reproduction"},{"issue":"1","key":"2025110222263482600_R83","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1096\/fasebj.11.1.9034166","article-title":"Growth factors in the extracellular matrix.","volume":"11","author":"Taipale","year":"1997","journal-title":"The FASEB Journal"},{"issue":"2","key":"2025110222263482600_R84","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1095\/biolreprod62.2.235","article-title":"Bovine blastocyst-derived trophectoderm and endoderm cell cultures: interferon tau and transferrin expression as respective in vitro markers.","volume":"62","author":"Talbot","year":"2000","journal-title":"Biology of Reproduction"},{"issue":"3","key":"2025110222263482600_R85","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1095\/biolreprod.104.032821","article-title":"A model for implantation: coculture of blastocysts and uterine endometrium in mice.","volume":"72","author":"Tan","year":"2005","journal-title":"Biology of Reproduction"},{"issue":"2","key":"2025110222263482600_R87","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2693","article-title":"Human endometrial stem cell isolation from endometrium and menstrual blood.","volume":"8","author":"Tavakol","year":"2018","journal-title":"Bio-Protocol"},{"issue":"1","key":"2025110222263482600_R88","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04809-y","article-title":"A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.","volume":"6","author":"Taylor","year":"2023","journal-title":"Communications Biology"},{"issue":"8","key":"2025110222263482600_R103","doi-asserted-by":"publisher","first-page":"11015","DOI":"10.1096\/fj.202000882RR","article-title":"The role of CAPG in molecular communication between the embryo and the uterine endometrium: is its function conserved in species with different implantation strategies?","volume":"34","author":"Tinning","year":"2020","journal-title":"The FASEB Journal"},{"issue":"6","key":"2025110222263482600_R89","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go.","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"issue":"6","key":"2025110222263482600_R90","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1177\/0272989X14535984","article-title":"Predictive modeling of implantation outcome in an in vitro fertilization setting: an application of machine learning methods.","volume":"35","author":"Uyar","year":"2015","journal-title":"Medical Decision Making"},{"issue":"4","key":"2025110222263482600_R91","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1093\/humrep\/deaa013","article-title":"Development of an artificial intelligence-based assessment model for prediction of embryo viability using static images captured by optical light microscopy during IVF.","volume":"35","author":"VerMilyea","year":"2020","journal-title":"Human Reproduction"},{"issue":"10","key":"2025110222263482600_R92","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1290\/1071-2690(2000)036&lt;0650:IIAICO&gt;2.0.CO;2","article-title":"Isolation, immortalization, and initial characterization of uterine cell lines: an in vitro model system for the porcine uterus.","volume":"36","author":"Wang","year":"2000","journal-title":"In Vitro Cellular & Developmental Biology \u2013 Animal"},{"issue":"5","key":"2025110222263482600_R93","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112439","article-title":"Establishment of bovine trophoblast stem cells.","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Reports"},{"issue":"7101","key":"2025110222263482600_R94","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature05058","article-title":"The origins and the future of microfluidics.","volume":"442","author":"Whitesides","year":"2006","journal-title":"Nature"},{"key":"2025110222263482600_R95","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14584","article-title":"A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle.","volume":"8","author":"Xiao","year":"2017","journal-title":"Nature Communications"},{"issue":"5","key":"2025110222263482600_R96","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.rbmo.2022.06.022","article-title":"Comparison of machine learning classification techniques to predict implantation success in an IVF treatment cycle.","volume":"45","author":"Yi\u011fit","year":"2022","journal-title":"Reproductive BioMedicine Online"},{"issue":"5","key":"2025110222263482600_R98","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.mam.2012.12.011","article-title":"Physiological and molecular determinants of embryo implantation.","volume":"34","author":"Zhang","year":"2013","journal-title":"Molecular Aspects of Medicine"}],"container-title":["Reproduction, Fertility and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/36\/2\/81\/1325910\/rd23181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/connectsci.au\/rd\/article-pdf\/36\/2\/81\/1325910\/rd23181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T03:26:37Z","timestamp":1762140397000},"score":1,"resource":{"primary":{"URL":"https:\/\/connectsci.au\/rd\/article\/36\/2\/81\/194338\/Understanding-conceptus-maternal-interactions-what"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":104,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,12,8]]}},"URL":"https:\/\/doi.org\/10.1071\/rd23181","relation":{},"ISSN":["1031-3613","1448-5990"],"issn-type":[{"value":"1031-3613","type":"print"},{"value":"1448-5990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]}}}