{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:53:37Z","timestamp":1778640817807,"version":"3.51.4"},"reference-count":20,"publisher":"CSIRO Publishing","issue":"13","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":298,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Preeclampsia is a common pregnancy complication, posing significant risks to both the mother and fetus. Predicting and determining the risks of this disease is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This research aims to understand the pathogenetic role of several factors in the development and progression of preeclampsia, particularly in relation to its severity in pregnant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 60 pregnant women diagnosed with either mild or severe preeclampsia and 40 healthy pregnant women for comparison. Blood plasma was analysed using biochemical methods, and blood microcirculation parameters were determined to identify homeostatic abnormalities in early preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>A molecular genetic study revealed the frequency of the endothelial nitric oxide gene eNOSC774T. Homeostatic abnormalities were statistically correlated with polymorphic genotypes of the eNOSC774T gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The research found a correlation between the T774T eNOS genotype mutation and the severity of preeclampsia, alongside significant homeostasis abnormalities in patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>The T774T mutant genotype of the eNOS gene and higher levels of lipid peroxidation products are strongly linked to the severity and progression of preeclampsia. This highlights a significant connection between genetic predisposition and biochemical abnormalities in the disease\u2019s development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd23214","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T19:04:48Z","timestamp":1722539088000},"source":"Crossref","is-referenced-by-count":1,"title":["Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women"],"prefix":"10.1071","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7039-2876","authenticated-orcid":true,"given":"Irina","family":"Ismailova","sequence":"first","affiliation":[{"name":"ADepartment of General Medical Practice No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Republic of Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Zame","sequence":"additional","affiliation":[{"name":"BDepartment of Children\u2019s Diseases No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Republic of Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moldir","family":"Akhmedzhanova","sequence":"additional","affiliation":[{"name":"ADepartment of General Medical Practice No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Republic of Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuanysh","family":"Sultanov","sequence":"additional","affiliation":[{"name":"ADepartment of General Medical Practice No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Republic of Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galiya","family":"Tanzharykova","sequence":"additional","affiliation":[{"name":"CDepartment of Phthisiology and Dermatovenereology, West Kazakhstan Marat Ospanov Medical University, Aktobe 030012, Republic of Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"issue":"15","key":"2025102820335930600_R1","first-page":"111","article-title":"Pre-eclampsia \u2013 actual problem in modern obstetrics.","volume":"5","author":"Abdurahmanova","year":"2016","journal-title":"Interdisciplinary Science Reviews"},{"issue":"11","key":"2025102820335930600_R2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.12731\/2658-6649-2019-11-4-107-117","article-title":"Oxidative stress and preeclampsia.","volume":"4","author":"Afanasyeva","year":"2019","journal-title":"Siberian Journal of Life Sciences and Agriculture"},{"issue":"9","key":"2025102820335930600_R3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092605","article-title":"Role of nitric oxide in the cardiovascular and renal systems.","volume":"19","author":"Ahmad","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"2025102820335930600_R4","first-page":"4","article-title":"Hypertension in pregnancy and preeclampsia.","volume":"6","author":"Baranouskaya","year":"2017","journal-title":"Medical News"},{"issue":"6","key":"2025102820335930600_R5","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3889\/oamjms.2018.252","article-title":"Nitric oxide and pre-eclampsia: a comparative study in Ghana.","volume":"6","author":"Darkwa","year":"2018","journal-title":"Open Access Macedonian Journal of Medical Sciences"},{"issue":"4","key":"2025102820335930600_R6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.18097\/PBMC20166204447","article-title":"Pathogenetic significance of C774T single nucleotide polymorphism of the endothelial NO synthase gene in the development of metabolic syndrome.","volume":"62","author":"Fattakhow","year":"2016","journal-title":"Biomeditsinskaia Khimiia"},{"key":"2025102820335930600_R7","unstructured":"Fetisova IN, Panova IA, Malyshkina AI, Rokotyanskaya EA, Ratnikova SY, Smirnova EV, Fetisov NS, Nazarova AO (2014) Genetic aspects of preeclampsia. 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