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In vitro and in vivo studies have shown that plant extracts regulate gonadotropin-releasing hormone, kisspeptin, and gonadotropin expression and\/or secretion at the hypothalamic\u2013pituitary level and modulate somatic and germ cells, such as steroidogenesis, proliferation, apoptosis, and oxidative stress at the ovarian level. In this review, we report evidence for the role of certain plant extracts or plant bioactive compounds in the regulation of the hypothalamic\u2013pituitary-ovary axis and, consequently, for the treatment of female infertility. We will also summarize their possible involvement in ovarian disorders such as polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and ovarian cancers.<\/jats:p>","DOI":"10.1071\/rd24120","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T17:25:39Z","timestamp":1737998739000},"source":"Crossref","is-referenced-by-count":3,"title":["Selected plant extracts and female fertility: role in the regulation of the hypothalamo-pituitary-ovarian axis in normal and pathological conditions"],"prefix":"10.1071","volume":"37","author":[{"given":"Wijden","family":"Niama","sequence":"first","affiliation":[{"name":"ACNRS, INRAE, Universit\u00e9 de Tours, PRC, Nouzilly, France."},{"name":"BUniversit\u00e9 de Jendouba, Ecole Sup\u00e9rieure d\u2019Agriculture du Kef, Laboratoire d\u2019Appui \u00e0 la Durabilit\u00e9 des Syst\u00e8mes de Production Agricole dans la R\u00e9gion du Nord-Ouest, Le Kef 7179, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Ben Said","sequence":"additional","affiliation":[{"name":"BUniversit\u00e9 de Jendouba, Ecole Sup\u00e9rieure d\u2019Agriculture du Kef, Laboratoire d\u2019Appui \u00e0 la Durabilit\u00e9 des Syst\u00e8mes de Production Agricole dans la R\u00e9gion du Nord-Ouest, Le Kef 7179, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Rame","sequence":"additional","affiliation":[{"name":"ACNRS, INRAE, Universit\u00e9 de Tours, PRC, Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-9598","authenticated-orcid":true,"given":"Pascal","family":"Froment","sequence":"additional","affiliation":[{"name":"ACNRS, INRAE, Universit\u00e9 de Tours, PRC, Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mokhtar","family":"Mahouachi","sequence":"additional","affiliation":[{"name":"BUniversit\u00e9 de Jendouba, Ecole Sup\u00e9rieure d\u2019Agriculture du Kef, Laboratoire d\u2019Appui \u00e0 la Durabilit\u00e9 des Syst\u00e8mes de Production Agricole dans la R\u00e9gion du Nord-Ouest, Le Kef 7179, Tunisia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-7705","authenticated-orcid":true,"given":"Jo\u00eblle","family":"Dupont","sequence":"additional","affiliation":[{"name":"ACNRS, INRAE, Universit\u00e9 de Tours, PRC, Nouzilly, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"67","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025111818062853600_R1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2806111","article-title":"A standardized extract of Petasites hybridus L., containing the active ingredients petasins, acts as a pro-oxidant and triggers apoptosis through elevating of NF-\u03baB in a highly invasive human breast cancer cell line.","volume":"28","author":"Apostolova","year":"2023","journal-title":"Frontiers in Bioscience-Landmark"},{"issue":"8","key":"2025111818062853600_R2","first-page":"509","article-title":"The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress.","volume":"15","author":"Arabameri","year":"2017","journal-title":"International Journal of Reproductive BioMedicine"},{"key":"2025111818062853600_R3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.596525","article-title":"The traditional chinese medicine fuyou formula alleviates precocious puberty by inhibiting GPR54\/GnRH in the hypothalamus.","volume":"11","author":"Bai","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"2","key":"2025111818062853600_R4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S1521-6934(02)00119-0","article-title":"Polycystic ovary syndrome\u2014a systemic disorder?","volume":"17","author":"Balen","year":"2003","journal-title":"Best Practice & Research Clinical Obstetrics & Gynaecology"},{"key":"2025111818062853600_R5","doi-asserted-by":"publisher","DOI":"10.1007\/s12517-023-11522-x","article-title":"Habitat characterizations and suitability analysis for conservation implications of Gymnosphaera gigantea (Wall. ex Hook.) 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