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It would be evolutionarily advantageous if the mammalian ovary had developed a method to detect which developing ovarian follicles contain good-quality oocytes, and preferentially select them for ovulation. No such mechanism has been clearly identified to date. Oocyte-secreted factors (OSFs) such as BMP15 and GDF9, represent one form of communication from oocyte to follicle somatic cells. Herein we discuss the hypothesis that OSFs can increase the growth rate of ovarian follicles, which provides the follicle with a greater ability to compete for follicle dominance and selection for ovulation. Some limited evidence suggests that oocytes with higher OSF secretion produce higher quality embryos but further investigation is needed to firmly link the two concepts of OSFs providing an indication of oocyte quality, and OSFs increasing the chances of follicle selection for ovulation.<\/jats:p>","DOI":"10.1071\/rd24149","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:41:12Z","timestamp":1746391272000},"source":"Crossref","is-referenced-by-count":2,"title":["Is preovulatory follicle selection influenced by the production of oocyte-secreted factors?"],"prefix":"10.1071","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8393-1073","authenticated-orcid":true,"given":"Nicholas J.","family":"Anderson","sequence":"first","affiliation":[{"name":"ADepartment of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New 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