{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:25:00Z","timestamp":1788279900846,"version":"build-2803163510"},"reference-count":80,"publisher":"CSIRO Publishing","issue":"14","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,12]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Intermittent fasting (IF) is a dietary approach against obesity; however, investigations on its role in male fertility showed contradictory results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>As nuclear factor erythroid 2-related factor 2 (NRF2)\/mitogen-activated protein kinase p38 (MAPK)\/nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) signaling pathways regulate inflammation and pyrotosis, this study aimed to elucidate whether these pathways are involved in the underlying molecular mechanisms and to investigate the prophylactic effects of IF on male reproduction dysfunction in obese rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-four adult rats were divided as follows: Control lean (CL), control positive (CP), which were fed standard diet for four non-consecutive days\/week, with alternate fasting on the other 3\u00a0days (24\u00a0h fasting), high-fat diet group (HFD), and the HFD-fasting group (HFD-IF), which was fed a HFD, followed by fasting protocol as in CP group. Serum testosterone, inflammatory markers, semen analysis, testicular malondialdehyde (MDA) concentration, and superoxide dismutase (SOD) activity were measured. Also, testicular and epididymal histological study, immunohistochemical analysis of NLRP3 and NRF2 and reverse-transcription quantitative polymerase chain reaction (RT-qPCR) for mRNA expression of SIRT1, NRF2, p38AMPK and NLRP3 were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>Combining IF with HFD limited rats\u2019 testicular spermatic and steroidogenesis impairment, histopathological alterations, by upregulating SIRT1\/NRF2 and downregulating p38 MAPK\/NLRP3 signaling pathways versus the HFD group. In the HFD-IF group, oxidative and inflammatory markers had a significant decrease versus in the HFD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IF has a beneficial effect on male reproductive health and emphasizes the significance of customized dietary strategies for addressing male fertility issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Further investigation is required to clarify more prophylactic mechanisms of IF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd24187","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T02:30:07Z","timestamp":1756175407000},"source":"Crossref","is-referenced-by-count":4,"title":["Intermittent fasting restores fertility dysfunction caused by a high-fat diet in male rats: role of SIRT-1\/NRF2\/P38 MAPK\/NLRP3"],"prefix":"10.1071","volume":"37","author":[{"given":"Dalia A.","family":"Hemead","sequence":"first","affiliation":[{"name":"AMedical Physiology Department, Faculty of medicine, Zagazig University, El-Sharkia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanees F.","family":"El-Malkey","sequence":"additional","affiliation":[{"name":"AMedical Physiology Department, Faculty of medicine, Zagazig University, El-Sharkia, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-5703","authenticated-orcid":true,"given":"Mohamed","family":"Aref","sequence":"additional","affiliation":[{"name":"BAnatomy and Embryology Department, Faculty of Veterinary Medicine, Zagazig University, El-Sharkia 44519, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nievin Ahmed","family":"Mahran","sequence":"additional","affiliation":[{"name":"CBiochemistry Department, Faculty of Dentistry, Sinai University \u2013 Kantara Campus, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa","family":"ElSheikh","sequence":"additional","affiliation":[{"name":"BAnatomy and Embryology Department, Faculty of Veterinary Medicine, Zagazig University, El-Sharkia 44519, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Nassan","sequence":"additional","affiliation":[{"name":"DDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, P.O. 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