{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:46:51Z","timestamp":1763513211941,"version":"3.45.0"},"reference-count":31,"publisher":"CSIRO Publishing","issue":"17","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,24]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Overweight and obese patients tend to have more difficulty getting pregnant through in vitro fertilization (IVF), but it is still unclear whether this effect varies by ethnicity and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the effect obesity has on IVF among infertile, advanced-age (\u2265 35\u00a0years) Mexican women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospectively, data were collected from the INGENES Institute (2018\u20132022; n\u00a0=\u00a02,232). Pearson\u2019s correlation coefficient (r) was calculated to evaluate associations. The area under the receiver operating characteristic curve (AUC) determined the predictability of body mass index (BMI) for IVF with the highest Youden index score (sensitivity\u00a0+\u00a0specificity\u00a0\u2013\u00a01) as the optimal cutoff value. Logistic regression was used to calculate risk (odds ratios (ORs) with 95% confidence intervals (95%CIs)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>BMI was negatively correlated with IVF outcomes (P\u00a0&amp;lt;\u00a00.001): biochemical pregnancy (r\u00a0=\u00a0\u22120.164), clinical pregnancy (r\u00a0=\u00a0\u22120.188), and live birth (r\u00a0=\u00a0\u22120.202). BMI cutoffs to predict IVF success were: \u2264 25.1\u00a0kg\/m2 for biochemical pregnancy (AUC\u00a0=\u00a00.63; specificity\u00a0=\u00a071.4%; sensitivity\u00a0=\u00a050.1%); \u2264 24.0\u00a0kg\/m2 for clinical pregnancy (AUC\u00a0=\u00a00.65; specificity\u00a0=\u00a085.3%; sensitivity\u00a0=\u00a040.2%), and \u2264 24.0\u00a0kg\/m2 for live birth (AUC\u00a0=\u00a00.67; specificity\u00a0=\u00a085.7%; sensitivity\u00a0=\u00a044.4%). Overweight or obese patients had higher risks of not having transferable embryos (OR\u00a0=\u00a02.7, 95%CI: 2.1\u20133.4 and OR\u00a0=\u00a03.8, 95%CI: 2.5\u20135.6, respectively, P\u00a0&amp;lt;\u00a00.001) and failed embryo implantation (OR\u00a0=\u00a03.1, 95%CI: 2.3\u20133.9 and OR\u00a0=\u00a04.7, 95%CI: 3.2\u20137.1, respectively, P\u00a0&amp;lt;\u00a00.001). The risk of pregnancy loss was also higher in patients who were overweight (OR\u00a0=\u00a04.7, 95%CI: 2.4\u20139.4, P\u00a0&amp;lt;\u00a00.001) and obese (OR\u00a0=\u00a04.0, 95%CI: 1.5\u201310.8, P\u00a0=\u00a00.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMI was highly associated with and predicted IVF failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Obesity is a prevalent factor that affects each stage of IVF; diet and other weight management treatments need to be implemented to promote IVF success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd25072","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T03:25:49Z","timestamp":1762399549000},"source":"Crossref","is-referenced-by-count":0,"title":["The impact of obesogenic disturbances on in vitro fertilization outcomes in a Mexican population"],"prefix":"10.1071","volume":"37","author":[{"given":"Y\u00favika","family":"Reyes-Albarrac\u00edn","sequence":"first","affiliation":[{"name":"ADepartamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional Cinvestav-IPN, Avenida Instituto Polit\u00e9cnico Nacional 2508 Colonia San Pedro Zacatenco, Ciudad de M\u00e9xico 07360, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo M.","family":"Porchia","sequence":"additional","affiliation":[{"name":"BInstituto de Infertilidad y Gen\u00e9tica M\u00e9xico S.C., Ingenes, Carretera M\u00e9xico-Toluca 5420, Oficina 602, Colonia El Yaqui, Ciudad de M\u00e9xico 05320, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Elba","family":"Gonzalez-Mejia","sequence":"additional","affiliation":[{"name":"CDepartamento de Gen\u00e9tica, Facultad de Medicina, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Calle 13 Sur 2702, Colonia Los Volcanes, Puebla 72420, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-7587","authenticated-orcid":true,"given":"Esther","family":"L\u00f3pez-Bayghen","sequence":"additional","affiliation":[{"name":"ADepartamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional Cinvestav-IPN, Avenida Instituto Polit\u00e9cnico Nacional 2508 Colonia San Pedro Zacatenco, Ciudad de M\u00e9xico 07360, 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