{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:33:50Z","timestamp":1780893230981,"version":"3.54.1"},"reference-count":19,"publisher":"CSIRO Publishing","issue":"17","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,24]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Male carriers of balanced reciprocal translocations can experience impaired spermatogenesis and adverse pregnancy outcomes. The impact of translocation fragment size and breakpoint location on these outcomes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether the location and size of translocated fragments relate to spermatogenic function, embryo aneuploidy ratio, and pregnancy outcomes in couples with male chromosomal translocation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 103 couples with male reciprocal translocation were included and these couples underwent 116 pre-implantation genetic testing cycles. Patients were divided into Group A (at least one translocation segment size &amp;lt;10\u00a0Mb) and Group B (both segment sizes \u226510\u00a0Mb) to compare the association of translocation segment size on spermatogenic function, embryo aneuploidy ratio, and pregnancy outcomes. Additionally, patients were categorized into Group I (normal\/mild-moderate oligospermia) and Group II (severe oligospermia) on the basis of sperm concentration, to compare the relationship of translocation breakpoint position on semen output.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>No significant differences were found between Groups A and B in the proportion with severe oligozoospermia (26.47% vs 21.74%), euploid blastocyst rate (35.64% vs 36.18%), or cumulative pregnancy rate (42.11% vs 55.26%). However, the proportion of couples with 1q fragment was significantly higher in Group II than in Group I (16.28% vs 3.25%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The size of male autosomal translocation fragments is not significantly associated with sperm concentration or pregnancy outcomes, although translocations involving the 1q fragment may relate to spermatogenic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Genetic counseling for male translocation carriers should prioritize breakpoint location, particularly on 1q, over fragment size when evaluating spermatogenic impairment risk.<\/jats:p>\n                  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