{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T01:55:06Z","timestamp":1775526906964,"version":"3.50.1"},"reference-count":74,"publisher":"CSIRO Publishing","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,20]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Bovine uterine inflammation impairs fertility, animal welfare and economics. Balanced regulation of interleukin-1 family proteins is crucial to resolve endometrial inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>mRNA expression of interleukin 1B (IL1B) and its receptor antagonist (IL1RA) was examined in bovine endometrial explants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Endometrial explants from 26 cows were incubated with heat-inactivated pathogenic Escherichia coli, opportunistic Bacillus pumilus or commensal and potentially protective Lactobacillus buchneri (3, 14 and 24\u00a0h) and with cytokines (24\u00a0h; IL1B, IL17A, IL10). mRNA expression of IL1B and IL1RA was quantified via reverse-transcription quantitative polymerase chain reaction (RT-qPCR) and mixed effects models were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>IL1B mRNA expression increased after bacterial challenge at all timepoints (P\u00a0&amp;lt;\u00a00.001). IL1RA mRNA expression increased after Escherichia coli and Bacillus pumilus exposure only at 3\u00a0h, but after Lactobacillus buchneri at 14 and 24\u00a0h (P\u00a0&amp;lt;\u00a00.010). A pro-inflammatory shift of the IL1RA:IL1B ratio was detected at all timepoints and for all bacterial challenges (P\u00a0&amp;lt;\u00a00.020). Stimulation with IL10 reduced IL1B and IL1RA mRNA expression and shifted the IL1RA:IL1B ratio in an anti-inflammatory direction (P\u00a0&amp;lt;\u00a00.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed explant culture as a suitable model for analyzing inflammatory regulation in the bovine endometrium and identified IL10 as a potent modulator of endometrial IL1B and IL1RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Not only Escherichia coli and Bacillus pumilus, but also unexpectedly Lactobacillus buchneri, induced initial pro-inflammatory mRNA expression patterns to be different depending on culture duration. This highlights the need for further research on pathogenic and opportunistic versus potentially protective bacteria in bovine uterine health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd26013","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T01:07:05Z","timestamp":1775524025000},"source":"Crossref","is-referenced-by-count":0,"title":["IL10 is a potent modulator of IL1-mediated inflammation in bovine endometrial explants"],"prefix":"10.1071","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-6593","authenticated-orcid":true,"given":"Marie Margarete","family":"Meyerholz-Wohllebe","sequence":"first","affiliation":[{"name":"AClinic for Ruminants with Ambulatory and Herd Health Services, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Sonnenstr. 16, 85764 Oberschleissheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna 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