{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:52:39Z","timestamp":1791845559146,"version":"4.3.4"},"reference-count":18,"publisher":"CSIRO Publishing","issue":"15","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Endometrial dysbiosis has been linked to infertility, but its relationship with systemic immune activity remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine whether endometrial microbiota phenotype is associated with serum complement profiles in infertile women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 105 infertile women and classified endometrial microbiota by 16S rRNA gene sequencing as Lactobacillus-dominant microbiota (LDM) or non-LDM (NLDM). Complement data were available in 27 women: after excluding cases with missing C-reactive protein (CRP;\u00a0n\u00a0=\u00a02) or CRP above the 95th percentile (n\u00a0=\u00a02), 23 women were analyzed for C3\/C4 and 19 for CH50. Group comparisons used Welch\u2019s t-test and Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>NLDM was associated with lower serum C3 than LDM (101.5\u00a0\u00b1\u00a012.4 vs 121.0\u00a0\u00b1\u00a018.0\u00a0mg\/dL; P\u00a0=\u00a00.006). C4 and CH50 did not differ significantly between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endometrial dysbiosis was associated with selective C3 reduction in this infertile cohort, consistent with mild complement consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Serum C3, interpreted with microbiota profiling, may provide a practical adjunct marker of inflammation-related infertility in routine care. Larger prospective studies are needed to validate these preliminary findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd26056","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:31:52Z","timestamp":1791844312000},"source":"Crossref","is-referenced-by-count":0,"title":["Systemic complement C3 reduction in infertile women with endometrial dysbiosis: preliminary observations"],"prefix":"10.1071","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9874-5432","authenticated-orcid":true,"given":"Shinya","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"AFaculty of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Sato","sequence":"additional","affiliation":[{"name":"BDepartment of Internal Medicine, Mount Sinai Morningside and West, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5512-2260","authenticated-orcid":true,"given":"Hirotaka","family":"Matsumi","sequence":"additional","affiliation":[{"name":"CMatsumi Ladies Clinic, Tokyo, Japan."},{"name":"DM Life Creation Inc., Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"67","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"2026101218314746200_R1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-24-0197","article-title":"The effect of chronic inflammation on female fertility.","volume":"169","author":"Ameho","year":"2025","journal-title":"Reproduction"},{"key":"2026101218314746200_R2","doi-asserted-by":"publisher","DOI":"10.3390\/life15050762","article-title":"The role of the gut microbiota in female reproductive and gynecological health: insights into endometrial signaling pathways.","volume":"15","author":"Escorcia 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