{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:53:19Z","timestamp":1790909599714,"version":"4.1.0"},"reference-count":46,"publisher":"CSIRO Publishing","issue":"15","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1071\/journalslicense"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Naringenin is a citrus-derived flavanone with documented antioxidant, anti-inflammatory, and steroidogenic modulatory properties; yet, its effects under gonadotropin-stimulated superovulation have not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the impact of naringenin co-administration during a pregnant mare serum gonadotropin (PMSG)\/human chorionic gonadotropin (hCG) superovulation protocol on zygote yield, preimplantation embryo development, and ovarian and endometrial morphology in CD-1 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-four females (8\u201310\u00a0weeks) received PMSG with either naringenin (20\u00a0mg\/kg intraperitoneally; n\u00a0=\u00a012) or dimethyl sulfoxide vehicle (n\u00a0=\u00a012), followed by hCG 48\u00a0h later and mating with fertile males. Pronuclear-stage embryos were collected from oviducts 14\u201316\u00a0h post-mating and cultured in vitro for 96\u00a0h; cleavage and blastocyst formation were assessed at 24\u00a0h and 96\u00a0h respectively. Ovarian and uterine tissues were evaluated histopathologically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>Naringenin treatment significantly increased total zygote yield. Although cleavage rate was lower in the naringenin group (45% vs 53%), blastocyst formation among cleaved embryos was markedly higher (47% vs 25%). Treated animals exhibited significantly greater corpora lutea count, corpora lutea:cell ratio, ovarian diameter, and endometrial thickness. In silico molecular docking predicted favourable binding affinities of naringenin towards the progesterone receptor and follicle-stimulating hormone receptor, generating a computational hypothesis consistent with these in vivo findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Naringenin enhances blastocyst developmental competence and post-ovulatory ovarian parameters under superovulation conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>These findings support the potential of naringenin as an adjunct to gonadotropin-based reproductive biotechnology protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1071\/rd26141","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:16:10Z","timestamp":1790907370000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of naringenin on superovulation in mice: evaluation of zygote and blastocyst development, histopathology, and molecular docking insights"],"prefix":"10.1071","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-5342","authenticated-orcid":true,"given":"Muhammet M\u00fckerrem","family":"Kaya","sequence":"first","affiliation":[{"name":"ABurdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey. Email: hidayettutun@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Ali","family":"\u00c7ay","sequence":"additional","affiliation":[{"name":"BBurdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, Burdur, Turkey. Email: hacay@mehmetakif.edu.tr; ayhana@mehmetakif.edu.tr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Arslan","sequence":"additional","affiliation":[{"name":"CAksaray University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, Aksaray, Turkey. Email: ramazan.arslan@aksaray.edu.tr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla Elif \u00d6zg\u00fc","family":"Ay\u00f6zger","sequence":"additional","affiliation":[{"name":"DBurdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey. Email: layozger@mehmetakif.edu.tr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Kaymak","sequence":"additional","affiliation":[{"name":"EBiotherapeutic Products Research and Development Program, Institute of Public Health, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara, Etlik 06010, Turkey. Email: sibelkaymak@aybu.edu.tr; nilufervural@aybu.edu.tr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nil\u00fcfer","family":"Vural","sequence":"additional","affiliation":[{"name":"EBiotherapeutic Products Research and Development Program, Institute of Public Health, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara, Etlik 06010, Turkey. Email: sibelkaymak@aybu.edu.tr; nilufervural@aybu.edu.tr"},{"name":"FDepartment of Food Processing, Vocational School of Technical Sciences, Ankara Y\u0131ld\u0131r\u0131m Beyazit University, Ankara, \u00c7ubuk, 06760, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidayet","family":"Tutun","sequence":"additional","affiliation":[{"name":"ABurdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey. Email: hidayettutun@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Ata","sequence":"additional","affiliation":[{"name":"BBurdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination, Burdur, Turkey. 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